PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 05-APR-2025

⊟Summary

• organism: Streptococcus pneumoniae JJA
• locus tag: SPJ_RS01915 [old locus tag: SPJ_0378 ]
• pan locus tag^?: PNEUPAN001232000
• symbol: cbpG
• pan gene symbol^?: cbpG
• synonym:
• product: choline-binding protein CbpG

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPJ_RS01915 [old locus tag: SPJ_0378 ]
• symbol: cbpG
• product: choline-binding protein CbpG
• replicon: chromosome
• strand: +
• coordinates: 362517..363338
• length: 822
• essential: unknown

⊟Accession numbers

• Location: NC_012466 (362517..363338) NCBI
• BioCyc: SPJ_RS01915 BioCyc
• MicrobesOnline: see SPJ_0378
• PneumoBrowse for strain D39V: SPV_0356 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  
  ATGAATGTAGAAGGGAGGGGAAGTGCGAATTTTATTAAAGATAATGTGTTAATTACAGCG
  GCTCACAGCTACTACAGACATGACTATGGGAAAGAAGCGGATGATATTTATGTTCTTCCG
  GCTGTTAGTCCAAGTCAAGAACCATTTGGAAAGATCAAAGTAAAGGAAGTTCGTTATTTG
  AAGGAATTTAGAAATTTAAATTCTAAGGATGCAAGGGAATATGACTTGGCTTTATTAATT
  CTAGAAGAGCCCATTGGTGCAAAATTAGGGACTTTGGGTCTTCCTACTAGTCAAAAAAAT
  TTGACAGGAATAACTGTGACTATCACAGGCTATCCATCATATAATTTTAAAGTTCATCAA
  ATGTATACAGATAAAAAACAAGTTTTAAGTGATGATGGCATGTTCTTGGATTACCAAGTT
  GATACTTTAGAGGGGTCTAGTGGATCTACAGTTTATGATGCTAGTCACCGTGTAGTAGGA
  GTGCATACTTTAGGAGATGGAGCTAATCAAATTAACAGTGCAGTTAAATTAAATGAACGA
  AATTTGCCATTTATTTATTCGGTTCTTAAAGGTTACTCTCTTGAAGGATGGAAGAAAATA
  AATGGTAGTTGGTACCATTATAGACAACATGATAAACAAACGGGTTGGCAGGAGATAAAT
  GATACTTGGTATTATTTAGACAGTTCCGGTAAGATGCTTACAGATTGGCAAAAAGTAAAT
  GGAAAATGGTATTATCTCAATTCAAATGGAGCAATGGTTACAGGTAGCCAAACTATCGAT
  GGTAAAGTTTATAACTTCGCTTCATCTGGTGAGTGGATTTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  822
  

⊟Protein

⊟General

• locus tag: SPJ_RS01915 [old locus tag: SPJ_0378 ]
• symbol: CbpG
• description: choline-binding protein CbpG
• length: 273
• theoretical pI: 6.89925
• theoretical MW: 30905.4
• GRAVY: -0.536264

⊟Function

• TIGRFAM:
  glucan-binding repeat (TIGR04035; HMM-score: 48.2)
  and 1 more
  Signal transduction Regulatory functions Protein interactions exported signaling peptide, YydF/SAG_2028 family (TIGR04077; HMM-score: 11.4)
• TheSEED: see SPJ_0378
• PFAM:
  Choline_binding (CL0694) Choline_bind_1; Putative cell wall binding repeat (PF01473; HMM-score: 65)
  Choline_bind_3; Choline-binding repeat (PF19127; HMM-score: 64.6)
  and 6 more
  Peptidase_PA (CL0124) Trypsin; Trypsin (PF00089; HMM-score: 38.8)
  Trypsin_2; Trypsin-like peptidase domain (PF13365; HMM-score: 32.9)
  Choline_binding (CL0694) Choline_bind_2; Choline-binding repeat (PF19085; HMM-score: 27.1)
  Peptidase_PA (CL0124) Peptidase_S39; Peptidase S39 (PF02122; HMM-score: 16.7)
  PUA (CL0178) ASCH; ASCH domain (PF04266; HMM-score: 14.2)
  no clan defined CoV_S1_C; Coronavirus spike glycoprotein S1, C-terminal (PF19209; HMM-score: 12.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Extracellular
  • Cytoplasmic Score: 0.01
  • Cytoplasmic Membrane Score: 0.09
  • Cellwall Score: 0.18
  • Extracellular Score: 9.72
  • Internal Helices: 0
• DeepLocPro: Extracellular
  • Cytoplasmic Score: 0.0009
  • Cytoplasmic Membrane Score: 0.0003
  • Cell wall & surface Score: 0.008
  • Extracellular Score: 0.9908
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.014441
  • TAT(Tat/SPI): 0.002117
  • LIPO(Sec/SPII): 0.004783
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_001100146 NCBI
• UniProt: see SPJ_0378

⊟Protein sequence

• MNVEGRGSANFIKDNVLITAAHSYYRHDYGKEADDIYVLPAVSPSQEPFGKIKVKEVRYLKEFRNLNSKDAREYDLALLILEEPIGAKLGTLGLPTSQKNLTGITVTITGYPSYNFKVHQMYTDKKQVLSDDGMFLDYQVDTLEGSSGSTVYDASHRVVGVHTLGDGANQINSAVKLNERNLPFIYSVLKGYSLEGWKKINGSWYHYRQHDKQTGWQEINDTWYYLDSSGKMLTDWQKVNGKWYYLNSNGAMVTGSQTIDGKVYNFASSGEWI

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: cbpG > cbpF

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0356 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications

B Mann, C Orihuela, J Antikainen, G Gao, J Sublett, T K Korhonen, E Tuomanen
Multifunctional role of choline binding protein G in pneumococcal pathogenesis.
Infect Immun: 2006, 74(2);821-9
[PubMed:16428724] [WorldCat.org] [DOI] (P p)