From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 10-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN034156
  • locus tag: SPN034156_RS03550 [old locus tag: SPN034156_06560 ]
  • pan locus tag?: PNEUPAN003307000
  • symbol: mgaSpn
  • pan gene symbol?: mga2
  • synonym:
  • product: virulence factor transcriptional regulator MgaSpn

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN034156_RS03550 [old locus tag: SPN034156_06560 ]
  • symbol: mgaSpn
  • product: virulence factor transcriptional regulator MgaSpn
  • replicon: chromosome
  • strand: -
  • coordinates: 671367..672848
  • length: 1482
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021006 (671367..672848) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1587 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    ATGAGAGATTTATTATCTAAAAAAAGTCATAGGCAATTAGAATTATTAGAATTATTATTT
    GAACATAAACGTTGGTTTCATCGTTCTGAACTAGCAGAGTTATTAAATTGTACAGAACGT
    GCAGTCAAAGATGATCTATCCCATGTTAAATCTGCTTTTCCTGACTTGATTTTTCATTCT
    TCTACTAATGGTATACGCATTATTAATACCGATGATAGTGATATTGAAATGGTTTACCAT
    CATTTCTTTAAACATTCAACTCATTTTTCGATTTTAGAATTCATCTTCTTTAATGAAGGT
    TGTCAAGCTGAGAGTATTTGTAAAGAATTTTATATCAGTTCATCTTCGCTCTATCGTATT
    ATTAGCCAAATCAATAAAGTGATTAAAAGGCAATTTCAATTTGAAGTTAGTCTGACCCCT
    GTTCAAATCATTGGAAATGAGAGAGACATTCGTTACTTTTTTGCACAATATTTTTCAGAA
    AAATATTATTTCCTAGAATGGCCATTTGAAAATTTTTCATCAGAGCCACTATCTCAATTG
    TTAGAATTGGTTTATAAGGAAACAAGCTTTCCAATGAATTTGTCAACGCATAGAATGCTA
    AAGTTGCTCCTAGTTACGAACCTATATAGAATAAAGTTTGGTCATTTTATGGAAGTAGAT
    AAAGATTCTTTTAACGACCAAAGTTTGGATTTTTTAATGCAGGCAGAAGGAATAGAAGGT
    GTTGCTCAGAGTTTTGAATCAGAATACAATATCTCTTTAGATGAAGAAGTTGTTTGCCAA
    TTATTTGTGTCTTACTTTCAAAAAATGTTTTTCATAGATGAAAGTCTCTTTATGAAATGC
    GTAAAAAAGGATAGTTATGTTGAAAAATCTTACCATCTATTGAGTGATTTTATTGATCAG
    ATTTCAGTCAAGTATCAGATTGAAATGGAGAATAAGGATAATCTGATTTGGCATCTGCAT
    AATACCGCACATCTGTATCGTCAAGAGTTGTTTACTGAGTTTATTTTATTTGATCAAAAA
    GGGAATACAATCAGGAACTTTCAAAATATTTTTCCAAAATTTGTTTCAGATATAAAAAAA
    GAGCTTTCTCACTATTTAGAGACTCTTGAGGTTTGTTCTAGTTCAATGATGGTAAATCAT
    CTATCTTATACCTTCATCACTCATACCAAACATTTGGTGATTAATTTGCTACAAAATCAG
    CCTAAACTAAAGGTTTTAGTTATGAGTAATTTTGATCAGTATCATGCAAAATTCGTTGCA
    GAGACACTTTCTTATTATTGTAGCAATAATTTTGAACTGGAAGTTTGGACTGAATTAGAA
    TTATCAAAGGAATCTTTAGAAGATTCACCTTATGATATCATTATTTCTAATTTTATTATT
    CCTCCTATTGAAAATAAGAGACTCATCTATTCAAATAATATAAACACGGTCTCACTCATA
    TACTTGTTAAATGCCATGATGTTTATTCGATTAGATGAGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1482

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN034156_RS03550 [old locus tag: SPN034156_06560 ]
  • symbol: MgaSpn
  • description: virulence factor transcriptional regulator MgaSpn
  • length: 493
  • theoretical pI: 5.44004
  • theoretical MW: 58754.9
  • GRAVY: -0.178702

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED: see SPN034156_06560
  • PFAM:
    PRD (CL0166) PRD_Mga; M protein trans-acting positive regulator (MGA) PRD domain (PF08270; HMM-score: 355.7)
    and 5 more
    HTH (CL0123) Mga; Mga helix-turn-helix domain (PF05043; HMM-score: 97.3)
    HTH_Mga; M protein trans-acting positive regulator (MGA) HTH domain (PF08280; HMM-score: 72.3)
    HTH_11; HTH domain (PF08279; HMM-score: 27.4)
    HTH_7; Helix-turn-helix domain of resolvase (PF02796; HMM-score: 15.7)
    no clan defined YozE_SAM_like; YozE SAM-like fold (PF06855; HMM-score: 15.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.6942
    • Cytoplasmic Membrane Score: 0.2887
    • Cell wall & surface Score: 0.0006
    • Extracellular Score: 0.0165
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003041
    • TAT(Tat/SPI): 0.000359
    • LIPO(Sec/SPII): 0.000546
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001205280 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MRDLLSKKSHRQLELLELLFEHKRWFHRSELAELLNCTERAVKDDLSHVKSAFPDLIFHSSTNGIRIINTDDSDIEMVYHHFFKHSTHFSILEFIFFNEGCQAESICKEFYISSSSLYRIISQINKVIKRQFQFEVSLTPVQIIGNERDIRYFFAQYFSEKYYFLEWPFENFSSEPLSQLLELVYKETSFPMNLSTHRMLKLLLVTNLYRIKFGHFMEVDKDSFNDQSLDFLMQAEGIEGVAQSFESEYNISLDEEVVCQLFVSYFQKMFFIDESLFMKCVKKDSYVEKSYHLLSDFIDQISVKYQIEMENKDNLIWHLHNTAHLYRQELFTEFILFDQKGNTIRNFQNIFPKFVSDIKKELSHYLETLEVCSSSMMVNHLSYTFITHTKHLVINLLQNQPKLKVLVMSNFDQYHAKFVAETLSYYCSNNFELEVWTELELSKESLEDSPYDIIISNFIIPPIENKRLIYSNNINTVSLIYLLNAMMFIRLDE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Carolyn Hemsley, Elizabeth Joyce, David L Hava, Amita Kawale, Andrew Camilli
MgrA, an orthologue of Mga, Acts as a transcriptional repressor of the genes within the rlrA pathogenicity islet in Streptococcus pneumoniae.
J Bacteriol: 2003, 185(22);6640-7
[PubMed:14594838] [WorldCat.org] [DOI] (P p)Virtu Solano-Collado, Manuel Espinosa, Alicia Bravo
Activator role of the pneumococcal Mga-like virulence transcriptional regulator.
J Bacteriol: 2012, 194(16);4197-207
[PubMed:22661692] [WorldCat.org] [DOI] (I p)

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SPN034156_RS03550&oldid=138206"