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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 08-SEP-2024
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae D39V
- locus tag: SPV_RS08455 [old locus tag: SPV_1587 ]
- pan locus tag?: PNEUPAN003307000
- symbol: mgaSpn
- pan gene symbol?: mga2
- synonym:
- product: virulence factor transcriptional regulator MgaSpn
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPV_RS08455 [old locus tag: SPV_1587 ]
- symbol: mgaSpn
- product: virulence factor transcriptional regulator MgaSpn
- replicon: chromosome
- strand: -
- coordinates: 1604777..1606258
- length: 1482
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NZ_CP027540 (1604777..1606258) NCBI
- BioCyc: see SPV_1587
- MicrobesOnline:
- PneumoBrowse: SPV_1587 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1441ATGAGAGATTTATTATCTAAAAAAAGTCATAGGCAATTAGAATTATTAGAATTATTATTT
GAACATAAACGTTGGTTTCATCGTTCTGAACTAGCAGAGTTATTAAATTGTACAGAACGT
GCAGTCAAAGATGATCTATCCCATGTTAAATCTGCTTTTCCTGACTTGATTTTTCATTCT
TCTACTAATGGTATACGCATTATTAATACCGATGATAGTGATATTGAAATGGTTTACCAT
CATTTCTTTAAACATTCAACTCATTTTTCGATTTTAGAATTCATCTTCTTTAATGAAGGT
TGTCAAGCTGAGAGTATTTGTAAAGAATTTTATATCAGTTCATCTTCGCTCTATCGTATT
ATTAGCCAAATCAATAAAGTGATTAAAAGGCAATTTCAATTTGAAGTCAGTCTGACCCCT
GTTCAAATCATTGGAAACGAGAGAGACATTCGTTACTTTTTTGCACAATATTTTTCAGAA
AAATATTATTTCCTAGAATGGCCGTTTGAAAATTTTTCATCAGAGCCACTATCTCAATTG
TTAGAATTGGTTTATAAGGAAACAAGCTTTCCAATGAATTTGTCAACGCATAGAATGCTA
AAGTTGCTCCTAGTTACGAACCTATATAGAATAAAGTTTGGTCATTTTATGGAAGTAGAT
AAAGATTCTTTTAACGACCAAAGTTTGGATTTTTTAATGCAGGCAGAAGGAATAGAAGGT
GTTGCTCAGAGTTTTGAATCAGAATACAATATCTCTTTAGATGAAGAAGTTGTTTGCCAA
TTATTTGTGTCTTACTTTCAAAAAATGTTTTTCATAGATGAAAGTCTCTTTATGAAATGC
GTAAAAAAGGATAGTTATGTTGAAAAATCTTACCATCTATTGAGTGATTTTATTGATCAG
ATTTCAGTCAAGTATCAGATTGAAATTGAGAATAAGGATAATCTGATTTGGCATCTGCAT
AATACCGCACATCTGTATCGTCAAGAGTTGTTTACTGAGTTTATTTTATTTGATCAAAAA
GGGAATACAATCAGGAACTTTCAAAATATTTTTCCAAAATTTGTTTCAGATGTAAAAAAA
GAGCTTTCTCACTATTTAGAGACTCTTGAGGTTTGTTCTAGTTCAATGATGGTAAATCAT
CTATCTTATACCTTCATCACTCATACCAAACATTTGGTGATTAATTTGCTACAAAATCAG
CCTAAACTAAAGGTTTTGGTTATGAGTAATTTTGATCAGTATCATGCAAAATTCGTTGCA
GAGACACTTTCTTATTACTGTAGCAATAATTTTGAACTGGAAGTTTGGACTGAATTAGAA
TTATCAAAGGAATCTTTAGAAGATTCACCTTATGATATCATTATTTCTAATTTTATTATT
CCTCCTATTGAAAATAAGAGACTCATCTATTCAAATAATATAAACACGGTCTCACTCATA
TACTTGTTAAATGCCATGATGTTTATTCGATTAGATGAGTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPV_RS08455 [old locus tag: SPV_1587 ]
- symbol: MgaSpn
- description: virulence factor transcriptional regulator MgaSpn
- length: 493
- theoretical pI: 5.44004
- theoretical MW: 58722.8
- GRAVY: -0.174037
⊟Function[edit | edit source]
- TIGRFAM:
- TheSEED: data available for D39, Hungary19A-6, TIGR4
- PFAM: PRD (CL0166) PRD_Mga; M protein trans-acting positive regulator (MGA) PRD domain (PF08270; HMM-score: 357.6)and 5 moreHTH (CL0123) Mga; Mga helix-turn-helix domain (PF05043; HMM-score: 94.5)HTH_Mga; M protein trans-acting positive regulator (MGA) HTH domain (PF08280; HMM-score: 73)HTH_11; HTH domain (PF08279; HMM-score: 27.3)no clan defined YozE_SAM_like; YozE SAM-like fold (PF06855; HMM-score: 16.1)HTH (CL0123) HTH_7; Helix-turn-helix domain of resolvase (PF02796; HMM-score: 15.7)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.6872
- Cytoplasmic Membrane Score: 0.2954
- Cell wall & surface Score: 0.0006
- Extracellular Score: 0.0168
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.003041
- TAT(Tat/SPI): 0.000359
- LIPO(Sec/SPII): 0.000546
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: WP_001205275 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MRDLLSKKSHRQLELLELLFEHKRWFHRSELAELLNCTERAVKDDLSHVKSAFPDLIFHSSTNGIRIINTDDSDIEMVYHHFFKHSTHFSILEFIFFNEGCQAESICKEFYISSSSLYRIISQINKVIKRQFQFEVSLTPVQIIGNERDIRYFFAQYFSEKYYFLEWPFENFSSEPLSQLLELVYKETSFPMNLSTHRMLKLLLVTNLYRIKFGHFMEVDKDSFNDQSLDFLMQAEGIEGVAQSFESEYNISLDEEVVCQLFVSYFQKMFFIDESLFMKCVKKDSYVEKSYHLLSDFIDQISVKYQIEIENKDNLIWHLHNTAHLYRQELFTEFILFDQKGNTIRNFQNIFPKFVSDVKKELSHYLETLEVCSSSMMVNHLSYTFITHTKHLVINLLQNQPKLKVLVMSNFDQYHAKFVAETLSYYCSNNFELEVWTELELSKESLEDSPYDIIISNFIIPPIENKRLIYSNNINTVSLIYLLNAMMFIRLDE
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress: SPV_1587 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Carolyn Hemsley, Elizabeth Joyce, David L Hava, Amita Kawale, Andrew Camilli
MgrA, an orthologue of Mga, Acts as a transcriptional repressor of the genes within the rlrA pathogenicity islet in Streptococcus pneumoniae.
J Bacteriol: 2003, 185(22);6640-7
[PubMed:14594838] [WorldCat.org] [DOI] (P p)Virtu Solano-Collado, Manuel Espinosa, Alicia Bravo
Activator role of the pneumococcal Mga-like virulence transcriptional regulator.
J Bacteriol: 2012, 194(16);4197-207
[PubMed:22661692] [WorldCat.org] [DOI] (I p)