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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 10-APR-2025
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae SPN034156
- locus tag: SPN034156_RS05195 [old locus tag: SPN034156_09170 ]
- pan locus tag?: PNEUPAN003747000
- symbol: SPN034156_RS05195
- pan gene symbol?: pnpR
- synonym:
- product: response regulator transcription factor
⊟Additional information (user-provided)[edit | edit source]
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPN034156_RS05195 [old locus tag: SPN034156_09170 ]
- symbol: SPN034156_RS05195
- product: response regulator transcription factor
- replicon: chromosome
- strand: +
- coordinates: 945757..946464
- length: 708
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NC_021006 (945757..946464) NCBI
- BioCyc:
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_1908 PneumoBrowse
⊟Phenotype[edit | edit source]
⊟Additional information (user-provided)[edit | edit source]
⊟DNA sequence[edit | edit source]
- 1
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661ATGACAAAACAAGTCTTATTAGTGGATGATGAAGAACACATTCTGAGATTGCTTGACTAC
CATTTAAGTAAGGAAGGCTTTTCTACTCAATTGGTAACAAATGGACGGAAGGCCTTAGCT
TTGGCAGAAACAGAACCCTTTGATTTTATCTTGCTTGATATCATGTTACCACAATTAGAT
GGCATAGAAGTTTGTAAGCGGCTGAGAGCCAAAGGCATCAAAACTCCAATTATGATGGTT
TCTGCGAAAAGTGATGAATTTGATAAGGTTTTGGCCTTGGAATTAGGGGCTGATGACTAC
CTGACCAAGCCTTTTAGCCCTAGAGAATTGCTGGCACGTGTCAAGGCTGTCCTCAGGCGA
ACTAAAGGAGAACAAGAAGGAGATGATTCAGATAATATTGCTGACGATTCTTGGCTATTT
GGGACCTTGAAAGTATACCCTGAGCGTCATGAGGTCTACAAGGCGAATAAGTTACTGAGT
TTGACCCCAAAAGAATTTGAACTCTTGCTCTATCTTATGAAACATCCCAACATGACACTG
ACTAGAGAGCGTCTTTTGGAACGTATCTGGGGATATGACTTTGGGCAGGAAACACGTTTG
GTGGACGTTCATATTGGTAAGTTGAGGGAAAAAATTGAAGACAATCCTAAAGCCCCTCAA
TTTATTCGAACCATTCGGGGTTATGGTTATAAGTTCAAGGAGTTATAG60
120
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708
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPN034156_RS05195 [old locus tag: SPN034156_09170 ]
- symbol: SPN034156_RS05195
- description: response regulator transcription factor
- length: 235
- theoretical pI: 6.69439
- theoretical MW: 27254.4
- GRAVY: -0.379149
⊟Function[edit | edit source]
- TIGRFAM: Regulatory functions DNA interactions phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 220.2)Signal transduction Two-component systems phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 220.2)Regulatory functions DNA interactions heavy metal response regulator (TIGR01387; HMM-score: 180.4)and 7 moreproteobacterial dedicated sortase system response regulator (TIGR03787; HMM-score: 105.7)Central intermediary metabolism Nitrogen metabolism nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 62.5)Regulatory functions DNA interactions nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 62.5)Signal transduction Two-component systems nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 62.5)Cellular processes Sporulation and germination sporulation transcription factor Spo0A (TIGR02875; HMM-score: 54.5)Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 49)Regulatory functions DNA interactions PEP-CTERM-box response regulator transcription factor (TIGR02915; HMM-score: 24.2)
- TheSEED: see SPN034156_09170
- PFAM: CheY (CL0304) Response_reg; Response regulator receiver domain (PF00072; HMM-score: 108)HTH (CL0123) Trans_reg_C; Transcriptional regulatory protein, C terminal (PF00486; HMM-score: 96.3)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9939
- Cytoplasmic Membrane Score: 0.0024
- Cell wall & surface Score: 0.0002
- Extracellular Score: 0.0036
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.001625
- TAT(Tat/SPI): 0.000278
- LIPO(Sec/SPII): 0.000167
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: WP_000166477 NCBI
- UniProt:
⊟Additional information (user-provided)[edit | edit source]
⊟Protein sequence[edit | edit source]
- MTKQVLLVDDEEHILRLLDYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGIEVCKRLRAKGIKTPIMMVSAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLSLTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Additional information (user-provided)[edit | edit source]
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1908 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟'lacZ' fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Additional information (user-provided)[edit | edit source]
⊟Other information (user-provided)[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
J McCluskey, J Hinds, S Husain, A Witney, T J Mitchell
A two-component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae.
Mol Microbiol: 2004, 51(6);1661-75
[PubMed:15009893] [WorldCat.org] [DOI] (P p)Jiaqi J Zheng, Dhriti Sinha, Kyle J Wayne, Malcolm E Winkler
Physiological Roles of the Dual Phosphate Transporter Systems in Low and High Phosphate Conditions and in Capsule Maintenance of Streptococcus pneumoniae D39.
Front Cell Infect Microbiol: 2016, 6;63
[PubMed:27379215] [WorldCat.org] [DOI] (I e)