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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2023

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPNA45
  • locus tag: SPNA45_RS00710 [old locus tag: SPNA45_00128 ]
  • pan locus tag?: PNEUPAN003747000
  • symbol: SPNA45_RS00710
  • pan gene symbol?: pnpR
  • synonym:
  • product: response regulator transcription factor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNA45_RS00710 [old locus tag: SPNA45_00128 ]
  • symbol: SPNA45_RS00710
  • product: response regulator transcription factor
  • replicon: chromosome
  • strand: -
  • coordinates: 130071..130778
  • length: 708
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_018594 (130071..130778) NCBI
  • BioCyc: SPNA45_RS00710 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1908 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGACAAAACAAGTCTTATTAGTGGATGATGAAGAACACATTCTGAGATTGCTTGACTAC
    CATTTAAGTAAGGAAGGCTTTTCTACTCAATTGGTAACAAATGGACGGAAGGCCTTAGCT
    TTGGCAGAAACAGAACCCTTTGATTTTATCTTGCTTGATATCATGTTACCACAATTAGAT
    GGCATAGAAGTTTGTAAGCGGCTGAGAGCCAAAGGCATCAAAACTCCAATTATGATGGTT
    TCTGCGAAAAGTGATGAATTTGATAAGGTTTTGGCCTTGGAATTAGGGGCTGATGACTAC
    CTGACCAAGCCTTTTAGCCCTAGAGAATTGCTGGCACGTGTCAAGGCTGTCCTCAGGCGA
    ACTAAAGGAGAACAAGAAGGAGATGATTCAGATAATATTGCTGACGATTCTTGGCTATTT
    GGGACCTTGAAAGTATACCCTGAGCGTCATGAAGTCTACAAGGCGAATAAGTTACTGAGT
    TTGACCCCAAAAGAATTTGAACTCTTGCTCTATCTTATGAAACATCCCAACATGACACTG
    ACTAGAGAGCGTCTTTTGGAACGTATCTGGGGATATGACTTTGGGCAGGAAACACGTTTG
    GTGGACGTTCATATTGGTAAGTTGAGGGAAAAAATTGAAGACAATCCTAAAGCCCCTCAA
    TTTATTCGAACCATTCGGGGTTATGGTTATAAGTTCAAGGAGTTATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    708

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNA45_RS00710 [old locus tag: SPNA45_00128 ]
  • symbol: SPNA45_RS00710
  • description: response regulator transcription factor
  • length: 235
  • theoretical pI: 6.69439
  • theoretical MW: 27254.4
  • GRAVY: -0.379149

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 220.2)
    Signal transduction Signal transduction Two-component systems phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 220.2)
    Signal transduction Regulatory functions DNA interactions heavy metal response regulator (TIGR01387; HMM-score: 180.4)
    and 7 more
    proteobacterial dedicated sortase system response regulator (TIGR03787; HMM-score: 105.7)
    Metabolism Central intermediary metabolism Nitrogen metabolism nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 62.5)
    Signal transduction Regulatory functions DNA interactions nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 62.5)
    Signal transduction Signal transduction Two-component systems nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 62.5)
    Cellular processes Cellular processes Sporulation and germination sporulation transcription factor Spo0A (TIGR02875; HMM-score: 54.5)
    Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 49)
    Signal transduction Regulatory functions DNA interactions PEP-CTERM-box response regulator transcription factor (TIGR02915; HMM-score: 24.2)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    CheY (CL0304) Response_reg; Response regulator receiver domain (PF00072; HMM-score: 108)
    HTH (CL0123) Trans_reg_C; Transcriptional regulatory protein, C terminal (PF00486; HMM-score: 96.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9939
    • Cytoplasmic Membrane Score: 0.0024
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0036
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001625
    • TAT(Tat/SPI): 0.000278
    • LIPO(Sec/SPII): 0.000167
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000166477 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTKQVLLVDDEEHILRLLDYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGIEVCKRLRAKGIKTPIMMVSAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLSLTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

J McCluskey, J Hinds, S Husain, A Witney, T J Mitchell
A two-component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae.
Mol Microbiol: 2004, 51(6);1661-75
[PubMed:15009893] [WorldCat.org] [DOI] (P p)Jiaqi J Zheng, Dhriti Sinha, Kyle J Wayne, Malcolm E Winkler
Physiological Roles of the Dual Phosphate Transporter Systems in Low and High Phosphate Conditions and in Capsule Maintenance of Streptococcus pneumoniae D39.
Front Cell Infect Microbiol: 2016, 6;63
[PubMed:27379215] [WorldCat.org] [DOI] (I e)

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