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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 06-FEB-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 700669
  • locus tag: SPN23F10770 [new locus tag: SPN23F_RS05470 ]
  • pan locus tag?: PNEUPAN000484000
  • symbol: phpA
  • pan gene symbol?: phtD
  • synonym: phtB
  • product: putative streptococcal histidine triad protein PhpA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN23F10770 [new locus tag: SPN23F_RS05470 ]
  • symbol: phpA
  • product: putative streptococcal histidine triad protein PhpA
  • replicon: chromosome
  • strand: -
  • coordinates: 1053659..1056181
  • length: 2523
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    ATGAAAATTAATAAGAAATACCTTGTTGGTTCTGCGGCAGCTTTGATTTTAAGTGTTTGT
    TCTTACGAGTTGGGACTGTATCAAGCTAGAACGGTTAAGGAAAATAATCGTGTTTCCTAT
    ATAGATGGAAAACAAGCGACGCAAAAAACGGAGAATTTGACTCCTGATGAGGTTAGCAAG
    CGTGAAGGAATCAATGCTGAGCAAATCGTCATCAAGATAACAGACCAAGGCTATGTCACT
    TCACATGGCGACCACTATCATTATTACAATGGTAAGGTTCCTTATGATGCGATTTTCAGT
    GAAGAATTACTCATGAAAGATCCAAACTATAAGCTAAAAGATGAGGATATTGTTAATGAG
    GTCAAGGGTGGATATGTTATCAAGGTAGATGGAAAATACTATGTTTACCTTAAGGATGCT
    GCCCACGCGGATAACGTCCGTACAAAAGAGGAAATCAATCGACAAAAACAAGAACATAGT
    CAGTATCGTGAAGGAGGGACTCCAAGAAACGATGGAGCTGTTGCCTTGGCACGTTCGCAA
    GGACGCTATACTACAGATGATGGTTATATCTTTAATGCTTCTGATATCATAGAGGATACT
    GGTGATGCTTATATCGTTCCTCATGGAGATCATTACCATTACATTCCTAAGAATGAGTTA
    TCAGCTAGCGAGTTGGCTGCTGCAGAAGCCTTCCTATCTGGTCGGGGAAATCTGTCAAAT
    TCAAGAACCTATCGCCGACAAAATAGCGATAACACTTCAAGAACAAACTGGGTACCTTCT
    GTAAGCAATCCAGGAACTACAAATACTAACACAAGCAACAACAGCAACACTAACAGTCAA
    GCAAGTCAAAGTAATGACATTGATAGTCTCTTGAAACAGCTCTACAAACTGCCTTTGAGT
    CAACGCCATGTGGAATCTGATGGCCTTATTTTCGACCCAGCGCAAATCACAAGTCGAACA
    GCTAGAGGTGTTGCAGTGCCACACGGAGATCATTACCACTTCATCCCTTACTCTCAAATG
    TCTGAATTGGAAGAACGAATTGCTCGTATTATTCCCCTTCGTTATCGTTCAAACCATTGG
    GTACCAGATTCAAGACCAGAACAACCAAGTCCACAATCGACTCCAGAACCTAGTCCAAGT
    CCGCAATCTGCACCAAATCCTCAACCAGCTCCAAGCAATCCAATTGATGAGAAATTGGTC
    AAAGAAGCTGTTCGAAAAGTAGGCGATGGTTATGTCTTTGAGAAGAATGGAGTTTCTCGT
    TATATCCCAGCCAAGAATCTTTCAGCAGAAACAGCAGCAGGCATTGATAGCAAACTGGCC
    AAGCAGGAAAGTTTATCTCATAAGCTAGGAACTAAGAAAACTGACCTCCCATCTAGTGAT
    AGAGAATTTTACAATAAGGCTTATGACTTACTAGCAAGAATTCACCAAGATTTACTTGAT
    AATAAAGGTCGACAAGTTGATTTTGAGGTTTTGGATAACCTGTTGGAACGACTCAAGGAT
    GTCTCAAGTGATAAAGTCAAGTTAGTGGATGATATTCTTGCCTTCTTAGCTCCGATTCGT
    CATCCAGAACGTTTAGGAAAACCAAATGCGCAAATTACCTACACTGATGATGAGATTCAA
    GTAGCCAAGTTGGCAGGCAAGTACACAACAGAAGACGGTTATATCTTTGATCCTCGTGAT
    ATAACCAGTGATGAGGGGGATGCCTATGTAACTCCACATATGACCCATAGCCACTGGATT
    AAAAAAGATAGTTTGTCTGAAGCTGAGAGAGCGGCAGCCCAGGCTTATGCTAAAGAGAAA
    GGTTTGACCCCTCCTTCGACAGACCATCAGGATTCAGGAAATACTGAGGCAAAAGGAGCA
    GAAGCTATCTACAACCGCGTGAAAGCAGCTAAGAAGGTGCCACTTGATCGTATGCCTTAC
    AATCTTCAATATACTGTAGAAGTCAAAAACGGTAGTTTAATCATACCTCATTATGACCAT
    TACCATAACATCAAATTTGAGTGGTTTGACGAAGGCCTTTATGAGGCACCTAAGGGGTAT
    ACTCTTGAGGATCTTTTGGCGACTGTCAAGTACTATGTCGAACATCCAAACGAACGTCCG
    CATTCAGATAATGGTTTTGGTAACGCTAGTGACCATGTTCAAAGAAACAAAAATGGTCAA
    GCTGATACCAATCAAACGGAAAAACCAAGCGAGGAGAAACCTCAGACAGAAAAACCTGAG
    GAAGAAACCCCTCGAGAAGAGAAACCGCAAAGCGAGAAACCAGAGTCTCCAAAACCAACA
    GAGGAACCAGAAGAAGAATCACCAGAGGAATCAGAAGAACCTCAGGTCGAGACTGAAAAG
    GTTGAAGAAAAACTGAGAGAGGCTGAAGATTTACTTGGAAAAATCCAGGATCCAATTATC
    AAGTCCAATGCCAAAGAGACTCTCACAGGATTAAAAAATAATTTACTATTTGGCACCCAG
    GACAACAATACTATTATGGCAGAAGCTGAAAAACTATTGGCTTTATTAAAGGAGAATAAG
    TAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2523

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN23F10770 [new locus tag: SPN23F_RS05470 ]
  • symbol: PhpA
  • description: putative streptococcal histidine triad protein PhpA
  • length: 840
  • theoretical pI: 5.26617
  • theoretical MW: 94558.7
  • GRAVY: -0.929048

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Pathogenesis streptococcal histidine triad protein (TIGR01363; HMM-score: 748)
    and 1 more
    cobaltochelatase subunit (TIGR02442; EC 6.6.1.2; HMM-score: 6.1)
  • TheSEED  :
    • Streptococcal histidine triad protein
  • PFAM:
    no clan defined Strep_his_triad; Streptococcal histidine triad protein (PF04270; HMM-score: 250.4)
    and 3 more
    PHtD_u1; Unstructured region on Pneumococcal histidine triad protein (PF16645; HMM-score: 93.5)
    RNR_Alpha; Ribonucleotide reductase alpha domain (PF17975; HMM-score: 14.3)
    SAPS; SIT4 phosphatase-associated protein (PF04499; HMM-score: 5.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • SignalP: Signal peptide LIPO(Sec/SPII) length 19 aa
    • SP(Sec/SPI): 0.166653
    • TAT(Tat/SPI): 0.001816
    • LIPO(Sec/SPII): 0.800704
    • Cleavage Site: CS pos: 19-20. LSV-CS. Pr: 0.7944
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CAR68891 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKINKKYLVGSAAALILSVCSYELGLYQARTVKENNRVSYIDGKQATQKTENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDAIFSEELLMKDPNYKLKDEDIVNEVKGGYVIKVDGKYYVYLKDAAHADNVRTKEEINRQKQEHSQYREGGTPRNDGAVALARSQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELSASELAAAEAFLSGRGNLSNSRTYRRQNSDNTSRTNWVPSVSNPGTTNTNTSNNSNTNSQASQSNDIDSLLKQLYKLPLSQRHVESDGLIFDPAQITSRTARGVAVPHGDHYHFIPYSQMSELEERIARIIPLRYRSNHWVPDSRPEQPSPQSTPEPSPSPQSAPNPQPAPSNPIDEKLVKEAVRKVGDGYVFEKNGVSRYIPAKNLSAETAAGIDSKLAKQESLSHKLGTKKTDLPSSDREFYNKAYDLLARIHQDLLDNKGRQVDFEVLDNLLERLKDVSSDKVKLVDDILAFLAPIRHPERLGKPNAQITYTDDEIQVAKLAGKYTTEDGYIFDPRDITSDEGDAYVTPHMTHSHWIKKDSLSEAERAAAQAYAKEKGLTPPSTDHQDSGNTEAKGAEAIYNRVKAAKKVPLDRMPYNLQYTVEVKNGSLIIPHYDHYHNIKFEWFDEGLYEAPKGYTLEDLLATVKYYVEHPNERPHSDNGFGNASDHVQRNKNGQADTNQTEKPSEEKPQTEKPEEETPREEKPQSEKPESPKPTEEPEEESPEESEEPQVETEKVEEKLREAEDLLGKIQDPIIKSNAKETLTGLKNNLLFGTQDNNTIMAEAEKLLALLKENK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: AdcR* (repression) regulon
    AdcR*(TF)important in Zinc homeostasis; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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