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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 06-FEB-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 700669
  • locus tag: SPN23F12090 [new locus tag: SPN23F_RS06140 ]
  • pan locus tag?: PNEUPAN000230000
  • symbol: ntpA
  • pan gene symbol?: ntpA
  • synonym:
  • product: V-type sodium ATP synthase subunit A

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN23F12090 [new locus tag: SPN23F_RS06140 ]
  • symbol: ntpA
  • product: V-type sodium ATP synthase subunit A
  • replicon: chromosome
  • strand: -
  • coordinates: 1176191..1177966
  • length: 1776
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    TTGACTCAAGGGAAGATTATAAAAGTATCGGGACCTCTAGTTATTGCATCAGGTATGCAG
    GAGGCTAATATTCAAGATATTTGCCGTGTAGGTAAGCTAGGGTTAATCGGTGAAATTATT
    GAAATGAGAAGAGATCAGGCATCTATCCAAGTCTATGAAGAAACATCTGGTCTTGGTCCG
    GGAGAACCTGTTGTTACAACTGGAGAACCTCTCTCGGTTGAATTAGGGCCAGGATTGATT
    TCTCAAATGTTTGATGGCATACAACGCCCATTAGATCGATTTAAATTGGCTACTCATAAT
    GATTTTCTAGTTCGTGGGGTAGAAGTTCCAAGTTTGGATAGAGATATTAAGTGGCATTTT
    GATTCCACTATAGCAATTGGTCAAAAAGTGAGTACGGGTGATATTCTTGGAACTGTCAAG
    GAAACCGAGGTAGTTAATCATAAAATTATGGTTCCTTATGGAGTATCTGGAGAAGTCGTT
    TCTATTGCATCTGGCGATTTTACAATTGATGAAGTTGTATATGAAATAAAAAAATTGGAC
    GGTAGTTTCTATAAAGGAACGCTTATGCAAAAATGGCCTGTCCGCAAGGCGCGTCCTGTT
    TCTAAACGTTTAATTCCAGAAGAACCATTAATCACAGGTCAACGAGTTATTGATGCATTC
    TTTCCAGTAACCAAAGGGGGAGCTGCAGCAGTTCCTGGACCGTTTGGAGCAGGAAAGACA
    GTTGTACAACACCAAGTAGCTAAATTTGCCAATGTTGATATTGTTATTTATGTCGGTTGT
    GGAGAACGTGGAAATGAAATGACGGATGTACTGAATGAGTTTCCTGAGTTGATTGACCCT
    AATACCGGACAATCAATTATGCAACGGACAGTTCTGATTGCTAATACTTCAAATATGCCT
    GTTGCTGCTCGTGAGGCTTCAATTTATACAGGAATTACCATGGCTGAGTATTTTCGTGAT
    ATGGGCTACTCTGTCGCCATTATGGCTGATTCAACTTCACGTTGGGCAGAAGCGCTACGT
    GAAATGTCAGGACGTCTAGAAGAAATGCCTGGTGATGAGGGTTATCCTGCTTATCTGGGA
    AGTCGTATCGCTGAATATTATGAAAGAGCAGGACGTTCTCAGGTTCTAGGGCTTCCAGAA
    CGTGAAGGAACGATTACTGCTATTGGAGCTGTATCGCCACCTGGTGGAGATATTTCAGAA
    CCAGTTACTCAAAACACTTTACGGATTGTGAAAGTTTTTTGGGGGCTTGATGCTCCGTTG
    GCACAGCGACGTCATTTTCCTGCAATTAACTGGCTTACATCTTATTCACTATATAAAGAC
    AGTGTGGGCACTTATATAGATGGTAAAGAGAAGACAGATTGGAATAGTAAAATAACTCGT
    GCGATGAACTACTTACAACGGGAATCTAGTTTAGAGGAAATTGTTCGTCTTGTTGGAATT
    GATTCTCTGTCTGATAATGAACGACTAACGATGGAAATTGCTAAACAAATTCGAGAAGAT
    TATTTGCAACAGAACGCTTTTGATTCGGTAGATACATTCACTTCGTTTGCAAAACAAGAA
    GCAATGCTAAGTAATATTCTCACTTTTGCTGATCAGGCAAATCATGCTTTAGAGTTGGGT
    TCTTACTTTACAGAGATTATGGAAGGTACCGTGGCAGTTCGAGACCGTATGGCGAGAAGT
    AAATATGTTTCAGAAGATAGATTAGATGAAATCAAAATTATATCAAATGAGATTACACAT
    CAAATTCATTTGATATTAGAAACAGGAGGTCTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1776

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN23F12090 [new locus tag: SPN23F_RS06140 ]
  • symbol: NtpA
  • description: V-type sodium ATP synthase subunit A
  • length: 591
  • theoretical pI: 4.77487
  • theoretical MW: 65278.9
  • GRAVY: -0.175127

⊟Function[edit | edit source]

  • reaction:
    EC 3.6.3.15?  ExPASy
    Sodium-transporting two-sector ATPase ATP + H2O + Na+(In) = ADP + phosphate + Na+(Out)
  • TIGRFAM:
    Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase archaeal, A subunit (TIGR01043; EC 3.6.3.14; HMM-score: 883.1)
    Metabolism Transport and binding proteins Cations and iron carrying compounds V-type ATPase, A subunit (TIGR01042; EC 3.6.3.14; HMM-score: 732.1)
    and 14 more
    Cellular processes Cellular processes Pathogenesis type III secretion apparatus H+-transporting two-sector ATPase (TIGR02546; EC 3.6.3.14; HMM-score: 179.2)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type III secretion apparatus H+-transporting two-sector ATPase (TIGR02546; EC 3.6.3.14; HMM-score: 179.2)
    Metabolism Energy metabolism ATP-proton motive force interconversion ATPase, FliI/YscN family (TIGR01026; EC 3.6.3.14; HMM-score: 176.7)
    Cellular processes Cellular processes Chemotaxis and motility flagellar protein export ATPase FliI (TIGR03497; EC 3.6.3.14; HMM-score: 171.5)
    Cellular processes Cellular processes Chemotaxis and motility flagellar protein export ATPase FliI (TIGR03496; EC 3.6.3.14; HMM-score: 164)
    flagellar protein export ATPase FliI (TIGR03498; EC 3.6.3.14; HMM-score: 161.1)
    Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase F1, beta subunit (TIGR01039; EC 3.6.3.14; HMM-score: 131.8)
    Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase archaeal, B subunit (TIGR01041; EC 3.6.3.14; HMM-score: 125.5)
    Metabolism Transport and binding proteins Cations and iron carrying compounds V-type ATPase, B subunit (TIGR01040; EC 3.6.3.14; HMM-score: 120.5)
    alternate F1F0 ATPase, F1 subunit beta (TIGR03305; EC 3.6.3.-; HMM-score: 115.7)
    Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase F1, alpha subunit (TIGR00962; EC 3.6.3.14; HMM-score: 90.1)
    alternate F1F0 ATPase, F1 subunit alpha (TIGR03324; EC 3.6.3.-; HMM-score: 85.3)
    Genetic information processing Transcription Transcription factors transcription termination factor Rho (TIGR00767; EC 3.6.4.-; HMM-score: 16.6)
    Genetic information processing Protein fate Protein modification and repair glycine radical enzyme activase, YjjW family (TIGR04041; EC 1.97.1.-; HMM-score: 11.8)
  • TheSEED  :
    • V-type ATP synthase subunit A (EC 3.6.3.14)
    Respiration ATP synthases V-Type ATP synthase  V-type ATP synthase subunit A (EC 3.6.3.14)
  • PFAM:
    P-loop_NTPase (CL0023) ATP-synt_ab; ATP synthase alpha/beta family, nucleotide-binding domain (PF00006; HMM-score: 315.8)
    and 3 more
    no clan defined ATP-synt_ab_Xtn; ATPsynthase alpha/beta subunit N-term extension (PF16886; HMM-score: 141.6)
    HAS-barrel (CL0275) ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain (PF02874; HMM-score: 42.2)
    P-loop_NTPase (CL0023) AAA_22; AAA domain (PF13401; HMM-score: 14.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.022366
    • TAT(Tat/SPI): 0.000797
    • LIPO(Sec/SPII): 0.007654
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTQGKIIKVSGPLVIASGMQEANIQDICRVGKLGLIGEIIEMRRDQASIQVYEETSGLGPGEPVVTTGEPLSVELGPGLISQMFDGIQRPLDRFKLATHNDFLVRGVEVPSLDRDIKWHFDSTIAIGQKVSTGDILGTVKETEVVNHKIMVPYGVSGEVVSIASGDFTIDEVVYEIKKLDGSFYKGTLMQKWPVRKARPVSKRLIPEEPLITGQRVIDAFFPVTKGGAAAVPGPFGAGKTVVQHQVAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMQRTVLIANTSNMPVAAREASIYTGITMAEYFRDMGYSVAIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLGSRIAEYYERAGRSQVLGLPEREGTITAIGAVSPPGGDISEPVTQNTLRIVKVFWGLDAPLAQRRHFPAINWLTSYSLYKDSVGTYIDGKEKTDWNSKITRAMNYLQRESSLEEIVRLVGIDSLSDNERLTMEIAKQIREDYLQQNAFDSVDTFTSFAKQEAMLSNILTFADQANHALELGSYFTEIMEGTVAVRDRMARSKYVSEDRLDEIKIISNEITHQIHLILETGGL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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