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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN994039
  • locus tag: SPN994039_RS05560 [old locus tag: SPN994039_10350 ]
  • pan locus tag?: PNEUPAN002386000
  • symbol: lpdA
  • pan gene symbol?: acoL
  • synonym:
  • product: dihydrolipoyl dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN994039_RS05560 [old locus tag: SPN994039_10350 ]
  • symbol: lpdA
  • product: dihydrolipoyl dehydrogenase
  • replicon: chromosome
  • strand: -
  • coordinates: 1056649..1058352
  • length: 1704
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021005 (1056649..1058352) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1025 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGGCCTTAGAAGTAATTATGCCAAAAGCCGGCGTGGATATGACAGAAGGACAAATCGTC
    CAATGGAATAAAAAAGTCGGAGAATTTGTAAAAGAAGGAGAAATCCTTTTGGAAATCATG
    ACTGATAAAGTAAGCATGGAATTGGAAGCCGAAGAAGATGGGTACTTGATTGCCATTCTC
    AAAGGAGATGGTGAAACTGTCCCTGTAACGGAAGTTATCGGTTACCTTGGTGAAGAAAGG
    GAAAACATCCCAACAGCTGGATCAGCATCGCCAGAAGCTAGCCCTGTCCCTGTAGCAAGT
    ACCTCAAACGATGATGGTAAGAGCGATGATGCTTTTGATATCGTTGTGATTGGTGGAGGT
    CCTGCTGGTTATGTTGCAGCCATTAAAGCTGCCCAACTCGGCGGTAAGGTTGCCCTTGTT
    GAGAAATCTGAACTTGGTGGAACCTGCTTAAACCGTGGATGTATTCCAACCAAGACCTAC
    CTTCATAACGCTGAAATTATTGAAAATATCGGTCATGCTGCAAATCGTGGTATCGTGATT
    GAAAATCCTAACTTCACTGTTGATATGGAAAAACTTTTAGAAACTAAATCTAAAGTTGTT
    AATACTCTTGTTGTTGGTGTTGCAGGACTTCTTCGTAGCTACGGAGTTACTGTTCATAAA
    GGAATTGGTACAATCACTAAAGACAAGAACGTCTTGGTAAATGGTTCTGAATTGCTTGAA
    ACCAAGAAGATCATTCTTGCTGGTGGTTCAAAAGTCAGCAAGATCAACGTCCCTGGTATG
    GAATCTCCACTTGTCATGACTAGTGATGACATTCTTGAAATGAACGAAGTGCCAGAAAGC
    CTTGTTATCATCGGTGGTGGAGTTGTCGGTATCGAACTCGGTCAGGCCTTCATGACATTT
    GGTTCAAAAGTGACTGTTATCGAAATGATGGACCGTATAGTTCCAGCTATGGATGCGGAA
    GTTTCTAAGAACCTTCGCTTGATCCTTGAGCGTAAAGGAATGACCATCTTGACTGGTACT
    AAACTGCAAGAAATCATTGAGGAAAATGGTCAACTTCGTATCAAGGTTGAAGGAAAAGAC
    AATATCATCGCAAGCAAAGCTCTTCTTTCAATTGGTCGTATGCCAGACCTTGAAGGTATT
    GGAGAGGTTGAGTTTGAATTGGATCGTGGTTGTATCAAGGTCAATGAATACATGGAAACT
    TCAGTTCCAGGCATTTATGCACCAGGTGACATCAACGGTACTAAGATGTTGGCTCACGCA
    GCTTTCCGCATGGGTGAAGTTTCCGCTGAAAATGCCCTTAAAGGAAATCATGCAGTTGCC
    AAATTGAATTTGACTCCTGCAGCCATCTACACTCTCCCTGAAGTAGCAGCAGTAGGTTTG
    ACAGAAGAACAAGCCCGTGAGAAATACGATGTTGCCATCGGTAAGTTTAACTTTGCTGCT
    AACGGTCGTGCTATTGCATCTGACGCAGCTCAAGGTTTCGTAAAAGTTATCGCTGATAAG
    AAATACGGAGAAATCCTTGGTGTACACATTATTGGTCCTGCAGCCGCAGAATTAATAAAC
    GAAGCATCAAGCATCATCGAAATGGAAATCACTGTTGAGGAAATGCTGAAGACCATCCAC
    GGACACCCAACTTACTCTGAAGTGATGTACGAAGCGTTTGCAGATGTTCTAGGAATGGCC
    ATCCATTCACCTAAGAAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1704

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN994039_RS05560 [old locus tag: SPN994039_10350 ]
  • symbol: LpdA
  • description: dihydrolipoyl dehydrogenase
  • length: 567
  • theoretical pI: 4.59188
  • theoretical MW: 60410.4
  • GRAVY: 0.0795414

⊟Function[edit | edit source]

  • reaction:
    EC 1.8.1.4?  ExPASy
    Dihydrolipoyl dehydrogenase Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH
  • TIGRFAM:
    dihydrolipoyl dehydrogenase (TIGR01350; EC 1.8.1.4; HMM-score: 563.4)
    and 53 more
    Cellular processes Cellular processes Detoxification mercury(II) reductase (TIGR02053; EC 1.16.1.1; HMM-score: 334.7)
    Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01424; EC 1.8.1.7; HMM-score: 255.1)
    Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01421; EC 1.8.1.7; HMM-score: 235)
    mycothione reductase (TIGR03452; EC 1.8.1.15; HMM-score: 216.6)
    thioredoxin and glutathione reductase (TIGR01438; EC 1.6.4.-; HMM-score: 167.4)
    trypanothione-disulfide reductase (TIGR01423; EC 1.8.1.12; HMM-score: 161.8)
    Cellular processes Cellular processes Detoxification CoA-disulfide reductase (TIGR03385; EC 1.8.1.14; HMM-score: 96.5)
    Cellular processes Cellular processes Detoxification alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 64.6)
    Cellular processes Cellular processes Adaptations to atypical conditions alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 64.6)
    Metabolism Energy metabolism TCA cycle dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex (TIGR01347; EC 2.3.1.61; HMM-score: 63.4)
    Metabolism Energy metabolism Electron transport thioredoxin-disulfide reductase (TIGR01292; EC 1.8.1.9; HMM-score: 63)
    Metabolism Energy metabolism Pyruvate dehydrogenase pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase (TIGR01349; EC 2.3.1.12; HMM-score: 62.8)
    Metabolism Central intermediary metabolism Nitrogen metabolism nitrite reductase [NAD(P)H], large subunit (TIGR02374; EC 1.7.1.4; HMM-score: 61)
    2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase (TIGR02927; EC 2.3.1.61; HMM-score: 52.8)
    Unknown function Enzymes of unknown specificity putative bacillithiol system oxidoreductase, YpdA family (TIGR04018; EC 1.8.-.-; HMM-score: 50.1)
    pyridine nucleotide-disulfide oxidoreductase family protein (TIGR03169; HMM-score: 43.6)
    mycofactocin system FadH/OYE family oxidoreductase 2 (TIGR03997; EC 1.-.-.-; HMM-score: 40.3)
    putative alkyl hydroperoxide reductase F subunit (TIGR03143; EC 1.6.4.-; HMM-score: 40.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase family (TIGR02032; EC 1.3.1.-; HMM-score: 32.5)
    Metabolism Amino acid biosynthesis Glutamate family glutamate synthase (NADPH), homotetrameric (TIGR01316; EC 1.4.1.13; HMM-score: 30.9)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UDP-galactopyranose mutase (TIGR00031; EC 5.4.99.9; HMM-score: 27.6)
    glutamate synthase, NADH/NADPH, small subunit (TIGR01317; EC 1.4.1.-; HMM-score: 27.3)
    Unknown function Enzymes of unknown specificity flavoprotein, HI0933 family (TIGR00275; HMM-score: 26.1)
    FAD dependent oxidoreductase TIGR03364 (TIGR03364; HMM-score: 24.1)
    Metabolism Energy metabolism Pyruvate dehydrogenase dihydrolipoyllysine-residue acetyltransferase (TIGR01348; EC 2.3.1.12; HMM-score: 23.5)
    mycofactocin system FadH/OYE family oxidoreductase 1 (TIGR03996; EC 1.-.-.-; HMM-score: 23.5)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, alpha subunit family (TIGR01372; HMM-score: 22.9)
    putative selenate reductase, YgfK subunit (TIGR03315; HMM-score: 20.9)
    Metabolism Energy metabolism Anaerobic glycerol-3-phosphate dehydrogenase, anaerobic, B subunit (TIGR03378; EC 1.1.5.3; HMM-score: 20.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides L-aspartate oxidase (TIGR00551; EC 1.4.3.16; HMM-score: 19.9)
    Metabolism Energy metabolism Electron transport flavocytochrome c (TIGR01813; HMM-score: 18.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase (TIGR02023; EC 1.3.1.-; HMM-score: 18.1)
    Metabolism Energy metabolism Amino acids and amines alanine dehydrogenase (TIGR00518; EC 1.4.1.1; HMM-score: 17.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family (TIGR01988; EC 1.14.13.-; HMM-score: 16)
    nucleotide sugar dehydrogenase (TIGR03026; HMM-score: 15.3)
    Metabolism Energy metabolism TCA cycle succinate dehydrogenase, flavoprotein subunit (TIGR01816; HMM-score: 15.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 2-polyprenyl-6-methoxyphenol 4-hydroxylase (TIGR01984; EC 1.14.13.-; HMM-score: 14.8)
    squalene-associated FAD-dependent desaturase (TIGR03467; HMM-score: 14.8)
    Metabolism Transport and binding proteins Cations and iron carrying compounds oxaloacetate decarboxylase alpha subunit (TIGR01108; EC 4.1.1.3; HMM-score: 14.7)
    Metabolism Energy metabolism Other oxaloacetate decarboxylase alpha subunit (TIGR01108; EC 4.1.1.3; HMM-score: 14.7)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, monomeric form (TIGR01377; HMM-score: 14.5)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA (TIGR00136; HMM-score: 13.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin precorrin 3B synthase CobZ (TIGR02485; HMM-score: 13.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase (TIGR02028; HMM-score: 13)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain (TIGR03197; HMM-score: 12.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiazole biosynthesis enzyme (TIGR00292; HMM-score: 12.6)
    lycopene cyclase family protein (TIGR01790; HMM-score: 11.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine glycine oxidase ThiO (TIGR02352; EC 1.4.3.19; HMM-score: 9.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other C-3',4' desaturase CrtD (TIGR02733; EC 1.3.99.-; HMM-score: 9.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other phytoene desaturase (TIGR02734; EC 1.14.99.-; HMM-score: 8.9)
    Metabolism Energy metabolism TCA cycle succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 7.7)
    Metabolism Energy metabolism Anaerobic succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 7.7)
    Metabolism Energy metabolism Aerobic succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 7.7)
  • TheSEED: data available for D39, TIGR4
  • PFAM:
    NADP_Rossmann (CL0063) Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 208.2)
    and 22 more
    Reductase_C (CL0608) Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain (PF02852; HMM-score: 123.1)
    NADP_Rossmann (CL0063) Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 80)
    Hybrid (CL0105) Biotin_lipoyl; Biotin-requiring enzyme (PF00364; HMM-score: 65.2)
    NADP_Rossmann (CL0063) Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase (PF13738; HMM-score: 60.3)
    GIDA; Glucose inhibited division protein A (PF01134; HMM-score: 39)
    FAD_oxidored; FAD dependent oxidoreductase (PF12831; HMM-score: 38.4)
    FAD_binding_2; FAD binding domain (PF00890; HMM-score: 29.4)
    HI0933_like; HI0933-like protein (PF03486; HMM-score: 26)
    DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 25.6)
    NAD_binding_8; NAD(P)-binding Rossmann-like domain (PF13450; HMM-score: 25.6)
    AlaDh_PNT_C; Alanine dehydrogenase/PNT, C-terminal domain (PF01262; HMM-score: 22.8)
    FAD_binding_3; FAD binding domain (PF01494; HMM-score: 21.3)
    NAD_binding_7; Putative NAD(P)-binding (PF13241; HMM-score: 20.4)
    Trp_halogenase; Tryptophan halogenase (PF04820; HMM-score: 19.7)
    Hybrid (CL0105) Biotin_lipoyl_2; Biotin-lipoyl like (PF13533; HMM-score: 16.8)
    NADP_Rossmann (CL0063) 3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 16.4)
    Thi4; Thi4 family (PF01946; HMM-score: 16.2)
    TrkA_N; TrkA-N domain (PF02254; HMM-score: 16.2)
    Hybrid (CL0105) HlyD_3; HlyD family secretion protein (PF13437; HMM-score: 14.6)
    NADP_Rossmann (CL0063) UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain (PF03721; HMM-score: 13.6)
    Hybrid (CL0105) PYNP_C; Pyrimidine nucleoside phosphorylase C-terminal domain (PF07831; HMM-score: 12.8)
    NADP_Rossmann (CL0063) Lycopene_cycl; Lycopene cyclase protein (PF05834; HMM-score: 12.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9828
    • Cytoplasmic Membrane Score: 0.0026
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0145
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002816
    • TAT(Tat/SPI): 0.000117
    • LIPO(Sec/SPII): 0.000216
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001162947 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MALEVIMPKAGVDMTEGQIVQWNKKVGEFVKEGEILLEIMTDKVSMELEAEEDGYLIAILKGDGETVPVTEVIGYLGEERENIPTAGSASPEASPVPVASTSNDDGKSDDAFDIVVIGGGPAGYVAAIKAAQLGGKVALVEKSELGGTCLNRGCIPTKTYLHNAEIIENIGHAANRGIVIENPNFTVDMEKLLETKSKVVNTLVVGVAGLLRSYGVTVHKGIGTITKDKNVLVNGSELLETKKIILAGGSKVSKINVPGMESPLVMTSDDILEMNEVPESLVIIGGGVVGIELGQAFMTFGSKVTVIEMMDRIVPAMDAEVSKNLRLILERKGMTILTGTKLQEIIEENGQLRIKVEGKDNIIASKALLSIGRMPDLEGIGEVEFELDRGCIKVNEYMETSVPGIYAPGDINGTKMLAHAAFRMGEVSAENALKGNHAVAKLNLTPAAIYTLPEVAAVGLTEEQAREKYDVAIGKFNFAANGRAIASDAAQGFVKVIADKKYGEILGVHIIGPAAAELINEASSIIEMEITVEEMLKTIHGHPTYSEVMYEAFADVLGMAIHSPKKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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