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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 27-FEB-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPNA45
  • locus tag: SPNA45_00915 [new locus tag: SPNA45_RS05180 ]
  • pan locus tag?: PNEUPAN002555000
  • symbol: SPNA45_00915
  • pan gene symbol?: licA
  • synonym:
  • product: putative kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNA45_00915 [new locus tag: SPNA45_RS05180 ]
  • symbol: SPNA45_00915
  • product: putative kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 898716..899504
  • length: 789
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGACCAATCAAAACTATTTGGCCAAAACAACAAATAAGCAATACATTGTTAAATTCTTT
    GGTAAAGGGACAGAAAAGCTTATCAATCGACAAGATGAAAAGTACAATCTTGAACTACTA
    AAGGATTTAGGCTTAGATGTAAAAAATTATCTTTTTGATATTGAAGCTGGTATCAAAGTA
    AATGAGTATATCGAATCTGCGATTACGCTTGATTCAACGTCAATCAAGACCAAGTTCGAC
    AAAATTGCTCCAATATTACAAACTATTCATACATCTGCTAAGGAATTAAGAGGAGAATTT
    GCTCCTTTTGAAGAAATCAAAAAATACGAATCCTTGATTGAAGAACAAATTCCTTATGCC
    AACTATGAATCTGTTAGAAATGCAGTCTTCTCCTTAGAGAAAAGACTGGCTGACTTAGGT
    GTTGACAGAAAATCTTGTCATATCGATTTGGTGCCTGAAAACTTTATCGAATCACCTCAA
    GGACGACTTTATTTGATTGACTGGGAATATTCATCAATGAATGATCCAATGTGGGATTTG
    GCTGCCCTCTTTTTAGAGTCTGAATTCACTTCCCAAGAGGAAGAAACTTTCTTATCTCAC
    TATGAGAGTGACCAAACACCGGTTTCTCATGAAAAGATTGCTATTTATAAAATTTTACAA
    GATACTATTTGGAGTCTATGGACTGTATATAAGGAAGAGCAAGGTGCAGATTTTGGTTAC
    TATGGTGTGAATCGTTACCAAAGAGCTGTTAAAGGTTTGGCTTCTTATGGAGGTTCAGAT
    GAAAAGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    789

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNA45_00915 [new locus tag: SPNA45_RS05180 ]
  • symbol: SPNA45_00915
  • description: putative kinase
  • length: 262
  • theoretical pI: 4.56743
  • theoretical MW: 30392.9
  • GRAVY: -0.519847

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiamine kinase (TIGR02721; EC 2.7.1.89; HMM-score: 64.4)
    and 3 more
    fibrobacter succinogenes paralogous family TIGR02172 (TIGR02172; HMM-score: 23.7)
    Metabolism Amino acid biosynthesis Aspartate family homoserine kinase (TIGR00938; EC 2.7.1.39; HMM-score: 18)
    Cellular processes Cellular processes Sporulation and germination spore coat protein YsxE (TIGR02904; HMM-score: 16.1)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    PKinase (CL0016) Choline_kinase; Choline/ethanolamine kinase (PF01633; HMM-score: 127.7)
    and 3 more
    APH; Phosphotransferase enzyme family (PF01636; HMM-score: 44.3)
    DUF1679; Uncharacterized oxidoreductase dhs-27 (PF07914; HMM-score: 13.6)
    HipA_C; HipA-like C-terminal domain (PF07804; HMM-score: 11.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002964
    • TAT(Tat/SPI): 0.000116
    • LIPO(Sec/SPII): 0.000353
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CCM08201 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTNQNYLAKTTNKQYIVKFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFDIEAGIKVNEYIESAITLDSTSIKTKFDKIAPILQTIHTSAKELRGEFAPFEEIKKYESLIEEQIPYANYESVRNAVFSLEKRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEFTSQEEETFLSHYESDQTPVSHEKIAIYKILQDTIWSLWTVYKEEQGADFGYYGVNRYQRAVKGLASYGGSDEK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Lei Wang, Yong-Liang Jiang, Jing-Ren Zhang, Cong-Zhao Zhou, Yuxing Chen
Structural and enzymatic characterization of the choline kinase LicA from Streptococcus pneumoniae.
PLoS One: 2015, 10(3);e0120467
[PubMed:25781969] [WorldCat.org] [DOI] (I e)

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