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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 03-APR-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu15
  • locus tag: SPNHU15_01983 [new locus tag: SPNHU15_RS09375 ]
  • pan locus tag?: PNEUPAN003587000
  • symbol: SPNHU15_01983
  • pan gene symbol?: rsmD
  • synonym:
  • product: N6-adenine-specific methylase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU15_01983 [new locus tag: SPNHU15_RS09375 ]
  • symbol: SPNHU15_01983
  • product: N6-adenine-specific methylase
  • replicon: chromosome
  • strand: -
  • coordinates: 1864822..1865361
  • length: 540
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: CP020551 (1864822..1865361) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1767 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGAAAATCATATCAGGAATCTATGGGGGACGTCCCCTTAAGACACTAGAAGGCAAGACA
    ACAAGACCTACTTCGGATAAGGTTAGGGGAGCCATTTTTAACATGATTGGTCCCTACTTT
    GAAGGGGGACGAGTCTTGGACCTTTATGCAGGTAGTGGTGGTTTATCTATCGAAGCAGTA
    TCGCGTGGCATGTCCAGTGCTGTTTTGGTGGAGCGAGACCGTAAGGCTCAGACCATCGTG
    GCTGAAAATATCCAGATGACCAAGGAAGTTGGAAAATTTCAACTCCTCAAAATGGATGCA
    GAAAGGGCATTGGAACAGGTATCTGGGGAATTTGACCTCGTTTTCTTAGACCCTCCCTAT
    GCCAAGGAACAAATCGTAGCAGATATTGAAAAAATGGCTGAGAGAGAGCTTTTTTCTGAA
    GATGTTATGGTTGTGTGCGAGACGGATAAAGCCGTTGAACTTCCAGAAGAAATTGCCTGT
    CTGGGTATCTGGAAGGAAAAGATTTATGGAATTAGTAAGGTGACAGTCTATGTCAGATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU15_01983 [new locus tag: SPNHU15_RS09375 ]
  • symbol: SPNHU15_01983
  • description: N6-adenine-specific methylase
  • length: 179
  • theoretical pI: 4.82793
  • theoretical MW: 19857.9
  • GRAVY: -0.0798883

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis tRNA and rRNA base modification 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD (TIGR00095; EC 2.1.1.171; HMM-score: 173)
    and 10 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit (TIGR02469; EC 2.1.1.132; HMM-score: 33)
    Genetic information processing Protein fate Protein modification and repair protein-(glutamine-N5) methyltransferase, release factor-specific (TIGR03534; EC 2.1.1.-; HMM-score: 29.1)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific (TIGR03533; EC 2.1.1.-; HMM-score: 26.8)
    Hypothetical proteins Conserved putative methyltransferase, TIGR01177 family (TIGR01177; HMM-score: 22.6)
    Genetic information processing Protein fate Protein modification and repair methyltransferase, HemK family (TIGR00536; HMM-score: 18.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll magnesium protoporphyrin O-methyltransferase (TIGR02021; EC 2.1.1.11; HMM-score: 16.7)
    Unknown function Enzymes of unknown specificity putative methylase (TIGR00537; HMM-score: 16.2)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification ribosomal protein L11 methyltransferase (TIGR00406; EC 2.1.1.-; HMM-score: 15.3)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA adenine methylase (TIGR00571; EC 2.1.1.72; HMM-score: 15)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 23S rRNA (uracil-5-)-methyltransferase RumA (TIGR00479; EC 2.1.1.-; HMM-score: 12.8)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    NADP_Rossmann (CL0063) Cons_hypoth95; Conserved hypothetical protein 95 (PF03602; HMM-score: 209.9)
    and 16 more
    MTS; Methyltransferase small domain (PF05175; HMM-score: 26)
    Methyltransf_24; Methyltransferase domain (PF13578; HMM-score: 21.9)
    Methyltransf_25; Methyltransferase domain (PF13649; HMM-score: 21.5)
    Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 19.9)
    N6-adenineMlase; Probable N6-adenine methyltransferase (PF10237; HMM-score: 19.4)
    MethyltransfD12; D12 class N6 adenine-specific DNA methyltransferase (PF02086; HMM-score: 18.5)
    PrmA; Ribosomal protein L11 methyltransferase (PrmA) (PF06325; HMM-score: 18.2)
    Methyltrans_SAM; S-adenosylmethionine-dependent methyltransferase (PF10672; HMM-score: 17.1)
    RsmJ; Ribosomal RNA large subunit methyltransferase D, RlmJ (PF04378; HMM-score: 16.2)
    UPF0020; Putative RNA methylase family UPF0020 (PF01170; HMM-score: 15.5)
    Met_10; Met-10+ like-protein (PF02475; HMM-score: 15.4)
    SAM_MT; Putative SAM-dependent methyltransferase (PF04445; HMM-score: 15.4)
    Methyltransf_15; RNA cap guanine-N2 methyltransferase (PF09445; HMM-score: 14.9)
    TRM; N2,N2-dimethylguanosine tRNA methyltransferase (PF02005; HMM-score: 14.2)
    Methyltransf_30; S-adenosyl-L-methionine-dependent methyltransferase (PF05430; HMM-score: 13.8)
    DNA_methylase; C-5 cytosine-specific DNA methylase (PF00145; HMM-score: 12.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9989
    • Cytoplasmic Membrane Score: 0.0001
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0008
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.026034
    • TAT(Tat/SPI): 0.002079
    • LIPO(Sec/SPII): 0.001454
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ARD37737 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKIISGIYGGRPLKTLEGKTTRPTSDKVRGAIFNMIGPYFEGGRVLDLYAGSGGLSIEAVSRGMSSAVLVERDRKAQTIVAENIQMTKEVGKFQLLKMDAERALEQVSGEFDLVFLDPPYAKEQIVADIEKMAERELFSEDVMVVCETDKAVELPEEIACLGIWKEKIYGISKVTVYVR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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