PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 07-MAR-2025

⊟Summary

• organism: Streptococcus pneumoniae Hu15
• locus tag: SPNHU15_RS06275
• pan locus tag^?: PNEUPAN002559000
• symbol: SPNHU15_RS06275
• pan gene symbol^?: —
• synonym:
• product: cysteine-rich KTR domain-containing protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNHU15_RS06275
• symbol: SPNHU15_RS06275
• product: cysteine-rich KTR domain-containing protein
• replicon: chromosome
• strand: -
• coordinates: 1263261..1263428
• length: 168
• essential: unknown

⊟Accession numbers

• Location: NZ_CP020551 (1263261..1263428) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  
  TTGTGTCCTGTATGTGGAAATAAAACACGATTAAAGATAAGGGAAGATACTGAATTAAAA
  AAATTCCCCCTCTATTGTCCGAAATGCAGACAAGAAAATTTAATTGAAATAAAGCAGTTC
  AAAGTAACTGTGATTACAGAGCCAGACGCAAAGACGCAGAGCCGATAA
  60
  120
  168
  

⊟Protein

⊟General

• locus tag: SPNHU15_RS06275
• symbol: SPNHU15_RS06275
• description: cysteine-rich KTR domain-containing protein
• length: 55
• theoretical pI: 9.44942
• theoretical MW: 6469.64
• GRAVY: -0.7

⊟Function

• TIGRFAM:
  cxxc_20_cxxc protein (TIGR04104; HMM-score: 14.8)
  YgiT-type zinc finger domain (TIGR03831; HMM-score: 14.1)
  Genetic information processing Mobile and extrachromosomal element functions Prophage functions restriction alleviation protein, Lar family (TIGR03655; HMM-score: 13.6)
  Genetic information processing DNA metabolism Restriction/modification restriction alleviation protein, Lar family (TIGR03655; HMM-score: 13.6)
  Signal transduction Regulatory functions DNA interactions putative regulatory protein, FmdB family (TIGR02605; HMM-score: 12.4)
• TheSEED:
• PFAM:
  no clan defined Cys_rich_KTR; Cysteine-rich KTR (PF14205; HMM-score: 102.5)
  and 24 more
  Zn_Beta_Ribbon (CL0167) Zn_Tnp_IS1595; Transposase zinc-ribbon domain (PF12760; HMM-score: 18.6)
  Elf1; Transcription elongation factor Elf1 like (PF05129; HMM-score: 18.5)
  zf-TFIIB; Transcription factor zinc-finger (PF13453; HMM-score: 18.5)
  Nudix_N_2; Nudix N-terminal (PF14803; HMM-score: 17.9)
  zf-ISL3; zinc-finger of transposase IS204/IS1001/IS1096/IS1165 (PF14690; HMM-score: 17.6)
  no clan defined zf-IS66; zinc-finger binding domain of transposase IS66 (PF13005; HMM-score: 16.6)
  Zn_Beta_Ribbon (CL0167) NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like (PF08772; HMM-score: 16.2)
  no clan defined Cys_rich_CPXG; Cysteine-rich CPXCG (PF14255; HMM-score: 15.6)
  Zn_Beta_Ribbon (CL0167) Zn_ribbon_SprT; SprT-like zinc ribbon domain (PF17283; HMM-score: 15.5)
  zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain (PF09297; HMM-score: 15)
  Lar_restr_allev; Restriction alleviation protein Lar (PF14354; HMM-score: 14.6)
  no clan defined DNA_ligase_ZBD; NAD-dependent DNA ligase C4 zinc finger domain (PF03119; HMM-score: 14.5)
  Zn_Beta_Ribbon (CL0167) Prim_Zn_Ribbon; Zinc-binding domain of primase-helicase (PF08273; HMM-score: 13.8)
  zinc_ribbon_2; zinc-ribbon domain (PF13240; HMM-score: 13.8)
  TF_Zn_Ribbon; TFIIB zinc-binding (PF08271; HMM-score: 13.7)
  no clan defined HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA (PF01155; HMM-score: 13.6)
  Zn_Beta_Ribbon (CL0167) DZR; Double zinc ribbon (PF12773; HMM-score: 13.1)
  CpXC; CpXC protein (PF14353; HMM-score: 12.3)
  TFIIS_C; Transcription factor S-II (TFIIS) (PF01096; HMM-score: 12.2)
  no clan defined zf-LITAF-like; LITAF-like zinc ribbon domain (PF10601; HMM-score: 12.2)
  C2H2-zf (CL0361) zf-H2C2_2; Zinc-finger double domain (PF13465; HMM-score: 11.8)
  no clan defined DUF5679; Domain of unknown function (DUF5679) (PF18930; HMM-score: 11.8)
  DUF3797; Domain of unknown function (DUF3797) (PF12677; HMM-score: 11.1)
  Zn_Beta_Ribbon (CL0167) Zn-ribbon_8; Zinc ribbon domain (PF09723; HMM-score: 10.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9665
  • Cytoplasmic Membrane Score: 0.0202
  • Cell wall & surface Score: 0.0012
  • Extracellular Score: 0.0121
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.01485
  • TAT(Tat/SPI): 0.001236
  • LIPO(Sec/SPII): 0.01145
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000336323 NCBI
• UniProt:

⊟Protein sequence

• MCPVCGNKTRLKIREDTELKKFPLYCPKCRQENLIEIKQFKVTVITEPDAKTQSR

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V:

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications