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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu15
  • locus tag: SPNHU15_RS10025 [old locus tag: SPNHU15_02110 ]
  • pan locus tag?: PNEUPAN003748000
  • symbol: pnpS
  • pan gene symbol?: pnpS
  • synonym:
  • product: two-component system histidine kinase PnpS

⊟Additional information (user-provided)[edit | edit source]

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU15_RS10025 [old locus tag: SPNHU15_02110 ]
  • symbol: pnpS
  • product: two-component system histidine kinase PnpS
  • replicon: chromosome
  • strand: +
  • coordinates: 1979069..1980400
  • length: 1332
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP020551 (1979069..1980400) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1909 PneumoBrowse

⊟Phenotype[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGAAACGCTACCTTCAATTTTGGCTAGTCAATCTAAGTGTTAGCCTCATTCTGATTGCA
    GGGATGGCATTAACTTGGATCAGTAAAGGCATCGGTCTCTTTCTTCTAGCCCTTTCTTTG
    GGACTAGGTGGCTACTGGCTCTTTTGCCTTTGGAAATGGGAAGTTGCTTTTGAGACCTTG
    CACCAACCTCTCTTGACCAGTAGTGAATACTTTTTAGAAAAAGGGCAAGAAGACTTAAAG
    TCTTTGGCTCAGTATGTGTCTGGCCTAAAAACCAAAGTCTCCCAACAGGATCAGCAATAC
    AAGGATCTAGCCGAAACAATGGAGGTTCTTCTGTCGCACCTAACCATGGGGACGTTTTTA
    GTTTCCGCTCAAGGTCAGATGTTATTATCCAGTCGCTCTCTGCCTCATTATTTTCCCGAT
    GTGGACGGCGACATAAGTTCACTTGATGACCTCAAACGGATGGATATTCGGAATTTAGTT
    CACCAAGCCTTTGATCAAAAAACAAGGTTAAAACAAGAAGTAAGTGGGTTTCATGAGGGT
    GACTTGATTTTAGAAGTGACAGCAGTTCCCGTTTTTAGCCCCACCCAATCTGTGGAAGCT
    GTGCTCGTCTTGCTATATGATTTAACAACGATTAGAACTTATGAAAAGTTAAATTTAGCC
    TTTGTCTCAAATGCCTCCCATGAATTGAGGACACCAGTTACTTCGATTAAGGGCTTTGCT
    GAAACCATTAAGGGGATGTCAGCTGAAGAAGAAGCGCTCAAGGATGACTTTCTAGACATT
    ATTTACAAAGAAAGTTTGCGTCTTGAGCATATTGTTGAGCATCTTCTTACCTTATCTAAG
    GCTCAACAAATGCCTATACAATGGACGACCCTTTCTTTGGCAGAATTTGTACAGGATTTG
    ACTCAAAGCTTGCAACCTCAGCTCAAGAAGAAGGATTTACAGCTAAAGGTGCAGGTGCCA
    GATGATGTCACCCTCGTATCAGATAGTCAATTACTTTCCCAAATCTTACTCAATCTTTTA
    TCCAATGCCATCCGTTACACTGAACAAGGGGGAAAAATTGAGGTCAAGACCCAAAAGGTG
    AACGAAGGCATTAAGATTTCTGTATCAGATACAGGGATTGGTATTAGTCAATTAGAGCAG
    GATCGTATTTTTGAACGTTTTTACCGAGTTAATAAAGGTCGAAGCAGACAAACTGGTGGC
    ACTGGTCTTGGCCTTGCCATTGTCAAAGAACTCAGTCAATTATTAGGTGGCCAAGTCACG
    GTGACGAGTCAGCTTGGCAGAGGCAGTTGCTTCACGATTTTTCTTCCTAACCAATCTTTC
    GCACAGGACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1332


⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU15_RS10025 [old locus tag: SPNHU15_02110 ]
  • symbol: PnpS
  • description: two-component system histidine kinase PnpS
  • length: 443
  • theoretical pI: 5.68422
  • theoretical MW: 49725.9
  • GRAVY: -0.0198646

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Signal transduction Two-component systems phosphate regulon sensor kinase PhoR (TIGR02966; EC 2.7.3.-; HMM-score: 241.8)
    and 9 more
    heavy metal sensor kinase (TIGR01386; EC 2.7.13.3; HMM-score: 144.2)
    Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 140.3)
    proteobacterial dedicated sortase system histidine kinase (TIGR03785; HMM-score: 75.7)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 74.6)
    Signal transduction Signal transduction Two-component systems putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 74.6)
    Metabolism Central intermediary metabolism Nitrogen fixation nitrogen fixation negative regulator NifL (TIGR02938; HMM-score: 28.2)
    Signal transduction Regulatory functions Protein interactions nitrogen fixation negative regulator NifL (TIGR02938; HMM-score: 28.2)
    Cellular processes Cellular processes Sporulation and germination anti-sigma F factor (TIGR01925; EC 2.7.11.1; HMM-score: 14)
    Signal transduction Regulatory functions Protein interactions anti-sigma F factor (TIGR01925; EC 2.7.11.1; HMM-score: 14)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    His_Kinase_A (CL0025) HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 103.1)
    and 5 more
    HisKA; His Kinase A (phospho-acceptor) domain (PF00512; HMM-score: 56)
    HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF13589; HMM-score: 20)
    HATPase_c_2; Histidine kinase-like ATPase domain (PF13581; HMM-score: 17.2)
    HATPase_c_5; GHKL domain (PF14501; HMM-score: 15)
    FtsL (CL0225) DivIC; Septum formation initiator (PF04977; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.17
    • Cytoplasmic Membrane Score: 9.51
    • Cellwall Score: 0.16
    • Extracellular Score: 0.15
    • Internal Helices: 2
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0317
    • Cytoplasmic Membrane Score: 0.9119
    • Cell wall & surface Score: 0.0016
    • Extracellular Score: 0.0549
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002422
    • TAT(Tat/SPI): 0.00072
    • LIPO(Sec/SPII): 0.056744
  • predicted transmembrane helices (TMHMM): 3

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000833270 NCBI
  • UniProt:

⊟Additional information (user-provided)[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKRYLQFWLVNLSVSLILIAGMALTWISKGIGLFLLALSLGLGGYWLFCLWKWEVAFETLHQPLLTSSEYFLEKGQEDLKSLAQYVSGLKTKVSQQDQQYKDLAETMEVLLSHLTMGTFLVSAQGQMLLSSRSLPHYFPDVDGDISSLDDLKRMDIRNLVHQAFDQKTRLKQEVSGFHEGDLILEVTAVPVFSPTQSVEAVLVLLYDLTTIRTYEKLNLAFVSNASHELRTPVTSIKGFAETIKGMSAEEEALKDDFLDIIYKESLRLEHIVEHLLTLSKAQQMPIQWTTLSLAEFVQDLTQSLQPQLKKKDLQLKVQVPDDVTLVSDSQLLSQILLNLLSNAIRYTEQGGKIEVKTQKVNEGIKISVSDTGIGISQLEQDRIFERFYRVNKGRSRQTGGTGLGLAIVKELSQLLGGQVTVTSQLGRGSCFTIFLPNQSFAQD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Additional information (user-provided)[edit | edit source]

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟'lacZ' fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟Other information (user-provided)[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]


⊟Relevant publications[edit | edit source]

J McCluskey, J Hinds, S Husain, A Witney, T J Mitchell
A two-component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae.
Mol Microbiol: 2004, 51(6);1661-75
[PubMed:15009893] [WorldCat.org] [DOI] (P p)Jiaqi J Zheng, Dhriti Sinha, Kyle J Wayne, Malcolm E Winkler
Physiological Roles of the Dual Phosphate Transporter Systems in Low and High Phosphate Conditions and in Capsule Maintenance of Streptococcus pneumoniae D39.
Front Cell Infect Microbiol: 2016, 6;63
[PubMed:27379215] [WorldCat.org] [DOI] (I e)

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