PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 07-MAR-2025

⊟Summary

• organism: Streptococcus pneumoniae Hu17
• locus tag: SPNHU17_RS00615 [old locus tag: SPNHU17_00126 ]
• pan locus tag^?: PNEUPAN000705000
• symbol: SPNHU17_RS00615
• pan gene symbol^?: cabP
• synonym:
• product: potassium channel family protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNHU17_RS00615 [old locus tag: SPNHU17_00126 ]
• symbol: SPNHU17_RS00615
• product: potassium channel family protein
• replicon: chromosome
• strand: +
• coordinates: 113935..114600
• length: 666
• essential: unknown

⊟Accession numbers

• Location: NZ_CP020549 (113935..114600) NCBI
• BioCyc: SPNHU17_RS00615 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0077 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  
  ATGTCAGATCGTACGATTGGAATTTTGGGCTTGGGAATTTTTGGGAGCAGTGTCCTAGCT
  GCCCTAGCCAAGCAGGATATGAATATTATCGCTATTGATGACCACGCAGAGCGCATCAAT
  CAGTTTGAGCCAGTTTTGGCGCGTGGAGTGATTGGTGACATCACAGATGAAGAATTATTG
  AGATCAGCAGGGATTGATACCTGCGATACCGTTGTAGTCGCGACAGGTGAAAATCTGGAG
  TCGAGTGTGCTTGCGGTTATGCACTGTAAGAGTTTGGGGGTACCGACTGTTATTGCTAAG
  GTCAAAAGTCAGACCGCTAAGAAAGTGCTAGAAAAGATTGGAGCTGACTCGGTTATCTCG
  CCAGAGTATGAAATGGGGCAGTCTCTAGCACAGACCATTCTTTTCCATAATAGTGTTGAT
  GTCTTTCAGTTGGATAAAAATGTGTCTATCGTGGAGATGAAAATTCCTCAGTCTTGGGCA
  GGTCAAAGTCTGAGTAAATTAGACCTCCGTGGCAAATACAATCTGAATATTTTGGGTTTC
  CGAGAGCAGGAAAATTCCCCATTGGATGTTGAATTTGGACCAGATGACCTCTTGAAAGCA
  GATACCTATATTTTGGCAGTCATCAACAACCAGTATTTGGATACCCTAGTAGCATTGAAT
  TCGTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  666
  

⊟Protein

⊟General

• locus tag: SPNHU17_RS00615 [old locus tag: SPNHU17_00126 ]
• symbol: SPNHU17_RS00615
• description: potassium channel family protein
• length: 221
• theoretical pI: 4.36773
• theoretical MW: 23960.3
• GRAVY: 0.114027

⊟Function

• TIGRFAM:
  putative phosphonate catabolism associated alcohol dehydrogenase (TIGR03366; HMM-score: 17.1)
  and 3 more
  Unknown function Enzymes of unknown specificity putative quinone oxidoreductase, YhdH/YhfP family (TIGR02823; HMM-score: 13.3)
  nucleotide sugar dehydrogenase (TIGR03026; HMM-score: 13)
  putative enoyl-[acyl-carrier-protein] reductase II (TIGR03151; EC 1.3.1.-; HMM-score: 13)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  NADP_Rossmann (CL0063) TrkA_N; TrkA-N domain (PF02254; HMM-score: 95.6)
  and 10 more
  2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 20.8)
  NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase (PF03446; HMM-score: 19.3)
  F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 19.3)
  ADH_zinc_N; Zinc-binding dehydrogenase (PF00107; HMM-score: 17.6)
  Epimerase; NAD dependent epimerase/dehydratase family (PF01370; HMM-score: 15.7)
  ApbA; Ketopantoate reductase PanE/ApbA (PF02558; HMM-score: 14.6)
  Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain (PF03435; HMM-score: 14.1)
  UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain (PF03721; HMM-score: 13.8)
  3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 13.4)
  DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 11.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.8546
  • Cytoplasmic Membrane Score: 0.1248
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0206
• SignalP: Signal peptide SP(Sec/SPI) length 23 aa
  • SP(Sec/SPI): 0.612182
  • TAT(Tat/SPI): 0.049331
  • LIPO(Sec/SPII): 0.09366
  • Cleavage Site: CS pos: 23-24. ALA-KQ. Pr: 0.4943
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_001283896 NCBI
• UniProt:

⊟Protein sequence

• MSDRTIGILGLGIFGSSVLAALAKQDMNIIAIDDHAERINQFEPVLARGVIGDITDEELLRSAGIDTCDTVVVATGENLESSVLAVMHCKSLGVPTVIAKVKSQTAKKVLEKIGADSVISPEYEMGQSLAQTILFHNSVDVFQLDKNVSIVEMKIPQSWAGQSLSKLDLRGKYNLNILGFREQENSPLDVEFGPDDLLKADTYILAVINNQYLDTLVALNS

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0077 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications