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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 25-OCT-2019
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae NU83127
- locus tag: SPNU_1043 [new locus tag: EL277_RS05490 ]
- pan locus tag?: PNEUPAN002239000
- symbol: rex
- pan gene symbol?: rex
- synonym:
- product: Redox-sensing transcriptional repressor Rex
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPNU_1043 [new locus tag: EL277_RS05490 ]
- symbol: rex
- product: Redox-sensing transcriptional repressor Rex
- replicon: chromosome
- strand: -
- coordinates: 1033631..1034272
- length: 642
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: AP018936 (1033631..1034272) NCBI
- BioCyc: see EL277_RS05490
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_0976 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
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601GTGAAAGATAAACAGTTTGCTATTCCAAAAGCTACAGCAAAAAGACTCTCTCTCTACTAT
CGAATTTTTAAGAGATTTCATGCAGAAAAGATTGAACGTGCCAACTCTAAGCAAATTGCA
GAGGCTATCGGTATTGATTCAGCGACCGTACGTCGTGATTTTTCCTATTTTGGTGAACTT
GGTCGTCGTGGTTTTGGCTATGATGTCAAAAAACTAATGACATTTTTTGCCGATTTGCTC
AATGACAACTCTATTACCAATGTCATGCTGGTTGGTATTGGAAATATGGGCCATGCCCTT
CTCCACTACCGCTTCCACGAACGTAACAAGATGAAGATTATCATGGCCTTTGACCTAGAC
GACCATCCTGAAGTCGGTACCCAAACTCCTGACGGGATTCCCATTTACGGGATTTCTCAG
ATCAAGGATAAAATCAAGGATGCTGATGTGAAGACTGCTATCCTAACTGTTCCCAGCGTC
AAGTCACAAGAGGTTGCTAATCTCTTGGTTGATGCTGGTGTGAAAGGAATTCTCAGTTTT
TCACCAGTCCATCTGCATTTACCAAAAGACGTGGTCGTTCAGTATGTCGATTTGACAAGT
GAACTCCAAACCCTCCTCTACTTCATGCGAAAAGAGGATTAG60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPNU_1043 [new locus tag: EL277_RS05490 ]
- symbol: Rex
- description: Redox-sensing transcriptional repressor Rex
- length: 213
- theoretical pI: 9.60544
- theoretical MW: 24164.9
- GRAVY: -0.164319
⊟Function[edit | edit source]
- TIGRFAM: undecaprenyl-phosphate glucose phosphotransferase (TIGR03023; EC 2.7.8.-; HMM-score: 16)and 2 moreexopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase (TIGR03025; HMM-score: 12.6)Regulatory functions DNA interactions mycofactocin system transcriptional regulator (TIGR03968; HMM-score: 12)
- TheSEED: data available for D39, Hungary19A-6, TIGR4
- PFAM: NADP_Rossmann (CL0063) CoA_binding; CoA binding domain (PF02629; HMM-score: 89.5)and 2 moreHTH (CL0123) Put_DNA-bind_N; Putative DNA-binding protein N-terminus (PF06971; HMM-score: 62.6)HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 14.7)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
- genes regulated by Rex*, TF important in Energy metabolism: in TIGR4
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic Membrane
- Cytoplasmic Score: 1.78
- Cytoplasmic Membrane Score: 8.16
- Cellwall Score: 0.06
- Extracellular Score: 0.01
- Internal Helices: 0
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.005911
- TAT(Tat/SPI): 0.0007
- LIPO(Sec/SPII): 0.000764
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: BBG34929 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MKDKQFAIPKATAKRLSLYYRIFKRFHAEKIERANSKQIAEAIGIDSATVRRDFSYFGELGRRGFGYDVKKLMTFFADLLNDNSITNVMLVGIGNMGHALLHYRFHERNKMKIIMAFDLDDHPEVGTQTPDGIPIYGISQIKDKIKDADVKTAILTVPSVKSQEVANLLVDAGVKGILSFSPVHLHLPKDVVVQYVDLTSELQTLLYFMRKED
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- data available for TIGR4
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0976 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Muhammad Afzal, Sulman Shafeeq, Oscar P Kuipers
NADH-Mediated Gene Expression in Streptococcus pneumoniae and Role of Rex as a Transcriptional Repressor of the Rex-Regulon.
Front Microbiol: 2018, 9;1300
[PubMed:29971050] [WorldCat.org] [DOI] (P e)