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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
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ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
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HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae P1031
  • locus tag: SPP_1030 [new locus tag: SPP_RS05095 ]
  • pan locus tag?: PNEUPAN002047000
  • symbol: glyA
  • pan gene symbol?: glyA
  • synonym:
  • product: serine hydroxymethyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPP_1030 [new locus tag: SPP_RS05095 ]
  • symbol: glyA
  • product: serine hydroxymethyltransferase
  • replicon: chromosome
  • strand: +
  • coordinates: 942577..943833
  • length: 1257
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGATTTTTGACAAAGATGATTTTAAAGCATATGATGCTGATCTCTGGAATGCTATTGCC
    AAAGAAGAAGAACGCCAACAAAATAATATCGAGTTAATTGCTTCGGAAAACGTAGTTTCC
    AAGGCTGTTATGGCAGCTCAAGGGTCTATCTTGACAAATAAATATGCCGAGGGTTACCCA
    GGACGCCGTTATTATGGTGGAACTGATGTAGTAGACGTTGTAGAGACTCTTGCTATTGAA
    CGCGCAAAAGAAATTTTCGGTGCTAAATTTGCCAATGTCCAACCACATTCAGGAAGCCAA
    GCTAACTGTGCGGCTTACATGTCCTTGATTGAGCCAGGTGATACGGTTATGGGAATGGAT
    TTGGCAGCAGGTGGACACTTGACCCACGGAGCTCCAGTTAGCTTCTCTGGTCAAACCTAC
    AACTTTCTTTCCTATAGTGTGGATCCTGAAACGGAACTTTTGGACTTTGATGCTATCTTG
    AAACAAGCCCAAGAAGTAAAACCAAAACTGATTGTAGCTGGTGCTTCAGCCTATTCTCAA
    ATTATTGACTTTTCAAAATTCCGTGAAATTGCAGATGCTGTTGGGGCTAAGCTTATGGTT
    GATATGGCCCACATCGCTGGCTTGGTTGCAGCTGGTCTTCACCCAAGCCCAGTGCCATAC
    GCTCATATCACTACAACAACGACCCACAAAACCCTTCGTGGTCCTCGTGGTGGTTTGATT
    TTGACCAATGATGAGGATTTAGCTAAGAAAATCAATTCAGCTATTTTCCCTGGTATTCAG
    GGTGGTCCTTTGGAGCATGTTGTGGCTGCTAAGGCAGTTTCCTTCAAAGAAGTTTTGGAT
    CCAGCTTTCAAGGAATATGCTGCCAATGTAATTAAGAACAGCAAGGCTATGGCAGATGTC
    TTCTTGCAAGACCCTGATTTCCGTATTATTTCAGGTGGAACTGAAAACCATCTCTTCCTT
    GTTGATGTGACTAAGGTTGTAGAAAACGGAAAAGTTGCTCAAAACTTGCTGGATGAAGTC
    AATATTACCCTAAATAAAAATTCAATCCCTTACGAAACCTTGTCACCATTCAAGACAAGT
    GGGATTCGTATCGGAGCAGCAGCTATTACTGCACGTGGATTTGGTGAAGAAGAAAGTCGC
    AAAGTGGCTGAACTCATCATTAAAACCCTTAAGAATTCAGAAAATGAGGCTGTATTAGAA
    GAAGTGAGAAGTGCAGTCAAAGAATTGACAGATGCCTTCCCATTATACGAGGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1257

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPP_1030 [new locus tag: SPP_RS05095 ]
  • symbol: GlyA
  • description: serine hydroxymethyltransferase
  • length: 418
  • theoretical pI: 4.80334
  • theoretical MW: 45256
  • GRAVY: -0.0973684

⊟Function[edit | edit source]

  • reaction:
    EC 2.1.2.1?  ExPASy
    Glycine hydroxymethyltransferase 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
  • TIGRFAM:
    Cellular processes Cellular processes Biosynthesis of natural products fluorothreonine transaldolase (TIGR04506; EC 2.2.1.8; HMM-score: 129)
    and 10 more
    dTDP-4-dehydro-6-deoxyglucose aminotransferase (TIGR04427; EC 2.-.-.-; HMM-score: 28.9)
    UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase (TIGR03588; EC 2.6.1.92; HMM-score: 28)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin 8-amino-7-oxononanoate synthase (TIGR00858; EC 2.3.1.47; HMM-score: 22.5)
    Metabolism Amino acid biosynthesis Aspartate family O-succinylhomoserine sulfhydrylase (TIGR01325; EC 4.2.99.-; HMM-score: 19)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 17.2)
    Metabolism Energy metabolism Amino acids and amines glycine C-acetyltransferase (TIGR01822; EC 2.3.1.29; HMM-score: 16.4)
    Unknown function Enzymes of unknown specificity pyridoxal phosphate enzyme, MJ0158 family (TIGR03576; HMM-score: 15.5)
    putative pyridoxal phosphate-dependent acyltransferase (TIGR01825; EC 2.3.1.-; HMM-score: 14.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin 5-aminolevulinic acid synthase (TIGR01821; EC 2.3.1.37; HMM-score: 11.7)
    Metabolism Transport and binding proteins Amino acids, peptides and amines mitochondrial precursor proteins import receptor (TIGR00990; HMM-score: 11.6)
  • TheSEED  :
    • Serine hydroxymethyltransferase (EC 2.1.2.1)
    Amino Acids and Derivatives Alanine, serine, and glycine Glycine and Serine Utilization  Serine hydroxymethyltransferase (EC 2.1.2.1)
    and 4 more
    Amino Acids and Derivatives Alanine, serine, and glycine Glycine Biosynthesis  Serine hydroxymethyltransferase (EC 2.1.2.1)
    Amino Acids and Derivatives Alanine, serine, and glycine Serine Biosynthesis  Serine hydroxymethyltransferase (EC 2.1.2.1)
    Carbohydrates One-carbon Metabolism Serine-glyoxylate cycle  Serine hydroxymethyltransferase (EC 2.1.2.1)
    Cofactors, Vitamins, Prosthetic Groups, Pigments Folate and pterines Folate Biosynthesis  Serine hydroxymethyltransferase (EC 2.1.2.1)
  • PFAM:
    PLP_aminotran (CL0061) SHMT; Serine hydroxymethyltransferase (PF00464; HMM-score: 551.6)
    and 5 more
    Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 40)
    DegT_DnrJ_EryC1; DegT/DnrJ/EryC1/StrS aminotransferase family (PF01041; HMM-score: 29.1)
    Beta_elim_lyase; Beta-eliminating lyase (PF01212; HMM-score: 24.8)
    no clan defined DUF6115; Family of unknown function (DUF6115) (PF19610; HMM-score: 15.3)
    PLP_aminotran (CL0061) Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9048
    • Cytoplasmic Membrane Score: 0.0009
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0942
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.016007
    • TAT(Tat/SPI): 0.006044
    • LIPO(Sec/SPII): 0.003753
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MIFDKDDFKAYDADLWNAIAKEEERQQNNIELIASENVVSKAVMAAQGSILTNKYAEGYPGRRYYGGTDVVDVVETLAIERAKEIFGAKFANVQPHSGSQANCAAYMSLIEPGDTVMGMDLAAGGHLTHGAPVSFSGQTYNFLSYSVDPETELLDFDAILKQAQEVKPKLIVAGASAYSQIIDFSKFREIADAVGAKLMVDMAHIAGLVAAGLHPSPVPYAHITTTTTHKTLRGPRGGLILTNDEDLAKKINSAIFPGIQGGPLEHVVAAKAVSFKEVLDPAFKEYAANVIKNSKAMADVFLQDPDFRIISGGTENHLFLVDVTKVVENGKVAQNLLDEVNITLNKNSIPYETLSPFKTSGIRIGAAAITARGFGEEESRKVAELIIKTLKNSENEAVLEEVRSAVKELTDAFPLYEE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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