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serotype 4
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serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Taiwan19F-14
  • locus tag: SPT_0306 [new locus tag: SPT_RS01545 ]
  • pan locus tag?: PNEUPAN000994000
  • symbol: ruvB
  • pan gene symbol?: ruvB
  • synonym:
  • product: holliday junction DNA helicase RuvB

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPT_0306 [new locus tag: SPT_RS01545 ]
  • symbol: ruvB
  • product: holliday junction DNA helicase RuvB
  • replicon: chromosome
  • strand: +
  • coordinates: 264753..265751
  • length: 999
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGAGTAGAATTTTAGATAATGAGATAATGGGGGATGAGGAGTTAGTAGAACGCACGCTC
    CGTCCTCAGTATTTACGTGAATATATTGGGCAGGATAAGGTTAAGGACCAGCTTCAAATC
    TTTATAGAAGCTGCCAAAATGCGAGATGAAGCGCTGGATCATGTCCTCTTATTTGGGCCT
    CCAGGTTTGGGGAAAACAACCATGGCTTTTGTCATTGCCAATGAACTGGGAGTCAATCTC
    AAGCAAACGTCTGGTCCTGTTATCGAAAAAGCGGGTGATTTGGTAGCGATTTTGAATGAG
    TTAGAGCCTGGAGATGTCCTCTTTATTGACGAGATTCATCGCTTACCCATGTCAGTGGAA
    GAAGTGCTTTATAGTGCCATGGAGGACTTCTACATCGATATTATGATTGGGGCTGGTGAA
    GGCAGTCGCAGTGTTCATTTGGAGTTGCCTCCTTTTACCTTGATTGGTGCGACGACTCGG
    GCTGGTATGCTCTCAAATCCACTACGGGCACGTTTTGGGATTACAGGTCATATGGAGTAT
    TATGCCCATGCTGACTTGACAGAAATTGTCGAGCGGACGGCAGATATTTTTGAGATGGAA
    ATCACTCATGAGGCAGCATCTGAGTTGGCCCTACGTAGTCGTGGAACCCCTCGTATTGCC
    AATCGTCTCCTCAAGCGCGTGCGCGATTTTGCCCAGATAATGGGGAATGGGGTAATCGAT
    GATATTATTACCGATAAGGCTTTGACTATGCTGGATGTTGACCATGAAGGTTTGGACTAT
    GTGGATCAAAAAATCCTTCGTACCATGATTGAGATGTACAGTGGAGGACCTGTTGGTCTA
    GGAACTCTTTCTGTCAATATCGCCGAAGAGCGTGAGACAGTTGAAGACATGTATGAGCCT
    TACTTGATTCAAAAAGGTTTTATCATGCGGACACGGTCTGGACGGGTGGCGACTGCTAAG
    GCATATGAGCACTTAGGTTATGAATACAGTGAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    999

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPT_0306 [new locus tag: SPT_RS01545 ]
  • symbol: RuvB
  • description: holliday junction DNA helicase RuvB
  • length: 332
  • theoretical pI: 4.50534
  • theoretical MW: 37288.5
  • GRAVY: -0.143373

⊟Function[edit | edit source]

  • reaction:
    EC 3.6.1.-?  ExPASy
  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair Holliday junction DNA helicase RuvB (TIGR00635; EC 3.6.4.12; HMM-score: 465.6)
    and 24 more
    Cellular processes Cellular processes Sporulation and germination ATP-dependent protease, Lon family (TIGR02903; EC 3.4.21.-; HMM-score: 37.8)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent protease, Lon family (TIGR02903; EC 3.4.21.-; HMM-score: 37.8)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 32.5)
    Cellular processes Cellular processes Sporulation and germination ATP-dependent protease LonB (TIGR02902; EC 3.4.21.-; HMM-score: 28.1)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent protease LonB (TIGR02902; EC 3.4.21.-; HMM-score: 28.1)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion AAA-ATPase EccA (TIGR03922; HMM-score: 25.2)
    AAA family ATPase, CDC48 subfamily (TIGR01243; HMM-score: 24.5)
    Cellular processes Cellular processes Sporulation and germination stage V sporulation protein K (TIGR02881; HMM-score: 23.2)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides endopeptidase La (TIGR00763; EC 3.4.21.53; HMM-score: 20.1)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp protease ATP-binding subunit ClpA (TIGR02639; HMM-score: 19.4)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides proteasome ATPase (TIGR03689; EC 3.6.4.8; HMM-score: 17.5)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides putative ATP-dependent protease (TIGR00764; HMM-score: 17.4)
    26S proteasome subunit P45 family (TIGR01242; HMM-score: 16.3)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair checkpoint protein rad24 (TIGR00602; HMM-score: 16)
    putative cytidylate kinase (TIGR02173; EC 2.7.4.14; HMM-score: 15.7)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair orc1/cdc6 family replication initiation protein (TIGR02928; HMM-score: 15.3)
    Cellular processes Cellular processes Cell division ATP-dependent metallopeptidase HflB (TIGR01241; EC 3.4.24.-; HMM-score: 15.2)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent metallopeptidase HflB (TIGR01241; EC 3.4.24.-; HMM-score: 15.2)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions adenylate kinase (TIGR01351; EC 2.7.4.-; HMM-score: 14.9)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 14.5)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair chromosomal replication initiator protein DnaA (TIGR00362; HMM-score: 14.3)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DnaA regulatory inactivator Hda (TIGR03420; HMM-score: 14.1)
    Unknown function General Mg chelatase-like protein (TIGR00368; HMM-score: 12.6)
    Cellular processes Cellular processes Other gas vesicle protein GvpN (TIGR02640; HMM-score: 11.8)
  • TheSEED  :
    • Holliday junction DNA helicase RuvB
    DNA Metabolism DNA recombination RuvABC plus a hypothetical  Holliday junction DNA helicase RuvB
    and 1 more
    DNA Metabolism DNA replication DNA-replication  Holliday junction DNA helicase RuvB
  • PFAM:
    P-loop_NTPase (CL0023) RuvB_N; Holliday junction DNA helicase RuvB P-loop domain (PF05496; HMM-score: 268.3)
    and 27 more
    AAA_lid (CL0671) AAA_lid_4; RuvB AAA lid domain (PF17864; HMM-score: 107)
    HTH (CL0123) RuvB_C; RuvB C-terminal winged helix domain (PF05491; HMM-score: 86.4)
    P-loop_NTPase (CL0023) AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 65.2)
    AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 34.6)
    TIP49; TIP49 P-loop domain (PF06068; HMM-score: 27.8)
    Sigma54_activat; Sigma-54 interaction domain (PF00158; HMM-score: 23)
    Mg_chelatase; Magnesium chelatase, subunit ChlI (PF01078; HMM-score: 22)
    AAA_14; AAA domain (PF13173; HMM-score: 20.5)
    Rad17; Rad17 P-loop domain (PF03215; HMM-score: 19.3)
    AAA_18; AAA domain (PF13238; HMM-score: 19.1)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 19)
    AAA_3; ATPase family associated with various cellular activities (AAA) (PF07726; HMM-score: 18.8)
    DUF815; Protein of unknown function (DUF815) (PF05673; HMM-score: 18.4)
    AAA_22; AAA domain (PF13401; HMM-score: 17.4)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 16.2)
    NTPase_1; NTPase (PF03266; HMM-score: 15.7)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 15.3)
    IstB_IS21; IstB-like ATP binding protein (PF01695; HMM-score: 14.3)
    AAA_17; AAA domain (PF13207; HMM-score: 14.2)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 14.1)
    Bac_DnaA; Bacterial dnaA protein (PF00308; HMM-score: 13.2)
    bpMoxR; MoxR domain in the MoxR-vWA-beta-propeller ternary systems (PF20030; HMM-score: 12.8)
    MCM; MCM P-loop domain (PF00493; HMM-score: 12.5)
    NB-ARC; NB-ARC domain (PF00931; HMM-score: 12.5)
    AAA_24; AAA domain (PF13479; HMM-score: 12.5)
    Sigma54_activ_2; Sigma-54 interaction domain (PF14532; HMM-score: 12.5)
    AAA_25; AAA domain (PF13481; HMM-score: 11.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9951
    • Cytoplasmic Membrane Score: 0.0037
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0013
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002385
    • TAT(Tat/SPI): 0.000212
    • LIPO(Sec/SPII): 0.000263
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSRILDNEIMGDEELVERTLRPQYLREYIGQDKVKDQLQIFIEAAKMRDEALDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPVIEKAGDLVAILNELEPGDVLFIDEIHRLPMSVEEVLYSAMEDFYIDIMIGAGEGSRSVHLELPPFTLIGATTRAGMLSNPLRARFGITGHMEYYAHADLTEIVERTADIFEMEITHEAASELALRSRGTPRIANRLLKRVRDFAQIMGNGVIDDIITDKALTMLDVDHEGLDYVDQKILRTMIEMYSGGPVGLGTLSVNIAEERETVEDMYEPYLIQKGFIMRTRSGRVATAKAYEHLGYEYSEK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: RegR* (repression) regulon
    RegR*(TF)important in Hyaluronate utilization; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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