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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-FEB-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39V
  • locus tag: SPV_0721 [new locus tag: SPV_RS03875 ]
  • pan locus tag?: PNEUPAN001793000
  • symbol: folD
  • pan gene symbol?: folD
  • synonym:
  • product: Bifunctional methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPV_0721 [new locus tag: SPV_RS03875 ]
  • symbol: folD
  • product: Bifunctional methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase
  • replicon: chromosome
  • strand: +
  • coordinates: 736391..737269
  • length: 879
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: CP027540 (736391..737269) NCBI
  • BioCyc: SPV_0721 BioCyc
  • MicrobesOnline:
  • PneumoBrowse: SPV_0721 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    TTGAAAGAAAAGAGAAGTGATATGACACAGATTATTGATGGGAAAGCTTTAGCGGCCAAA
    TTGCAGGGGCAGTTGGCTGAAAAGACTGCAAAATTAAAGGAAGAAACAGCTCTAGTGCCT
    GGTTTGGTAGTGATTTTGGTTGGGGATAATCCAGCCAGCCAAGTCTACGTTCGCAACAAG
    GAGAGGTCAGCTCTTGCGGCTGGTTCCCGTAGCGAAGTAGTGCGAGTTCCAGAGACCATT
    ACTCAAGAGGAATTGTTAGACCTGATTGCTAAATATAATCAGGATCCAGCTTGGCATGGG
    ATTTTGGTCCAGTTGCCATTACCAAAACATATCGATGAAGAGGCGGTTTTATTAGCCATT
    GACCCAGAAAAGGATGTGGATGGTTTCCATCCCCTAAACATGGGACGTCTTTGGTCTGGA
    CATCCAGTCATGATTCCCTCGACACCTGCAGGAATTATGGAAATGTTTCATGAATATGGG
    ATTGACTTGGAAGGTAAAAATGCGGTCGTAATCGGTCGTTCAAATATCGTTGGAAAACCT
    ATGGCTCAGCTTCTTTTGGCTAAAAATGCGACAGTAACCTTGACCCACTCACGAACTCAT
    AATCTTGCCAAGGTGGCTGCTAAAGCAGATATTCTTGTAGTCGCAATCGGCCGCGCCAAG
    TTTGTGACTGCTGACTTTGTCAAACCAGGTGCGGTTGTCATTGACGTTGGGATGAATCGA
    GATGAAAATGGGAAGCTCTGTGGAGATGTTGATTATGAGGCAGTTGCACCACTTGCTAGC
    CATATCACGCCAGTCCCTGGAGGTGTCGGTCCTATGACCATTACCATGCTGATGGAGCAA
    ACTTATCAAGCAGCACTTCGGACATTGGATAGAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    879

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPV_0721 [new locus tag: SPV_RS03875 ]
  • symbol: FolD
  • description: Bifunctional methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase
  • length: 292
  • theoretical pI: 6.72975
  • theoretical MW: 31554.5
  • GRAVY: -0.0157534

⊟Function[edit | edit source]

  • reaction:
    EC 1.5.1.5?  ExPASy
    Methylenetetrahydrofolate dehydrogenase (NADP+) 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH
    EC 3.5.4.9?  ExPASy
    Methenyltetrahydrofolate cyclohydrolase 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate
  • TIGRFAM:
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    NADP_Rossmann (CL0063) THF_DHG_CYH_C; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain (PF02882; HMM-score: 236.9)
    and 2 more
    AA_dh_N (CL0603) THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain (PF00763; HMM-score: 137.3)
    NADP_Rossmann (CL0063) adh_short; short chain dehydrogenase (PF00106; HMM-score: 14.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.009042
    • TAT(Tat/SPI): 0.001387
    • LIPO(Sec/SPII): 0.001463
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: AVN85859 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKEKRSDMTQIIDGKALAAKLQGQLAEKTAKLKEETALVPGLVVILVGDNPASQVYVRNKERSALAAGSRSEVVRVPETITQEELLDLIAKYNQDPAWHGILVQLPLPKHIDEEAVLLAIDPEKDVDGFHPLNMGRLWSGHPVMIPSTPAGIMEMFHEYGIDLEGKNAVVIGRSNIVGKPMAQLLLAKNATVTLTHSRTHNLAKVAAKADILVVAIGRAKFVTADFVKPGAVVIDVGMNRDENGKLCGDVDYEAVAPLASHITPVPGGVGPMTITMLMEQTYQAALRTLDRK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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