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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_0669 [new locus tag: SP_RS03285 ]
  • pan locus tag?: PNEUPAN001615000
  • symbol: thyA
  • pan gene symbol?: thyA
  • synonym:
  • product: thymidylate synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_0669 [new locus tag: SP_RS03285 ]
  • symbol: thyA
  • product: thymidylate synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 645132..645971
  • length: 840
  • essential: yes [1]

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGACAAAAGCAGATACGATTTTTAAAGAGAATATTGAACGCATTCTAAAGGAAGGTGTT
    TTCTCAGAGCAGGCTCGTCCTAAGTACAAGGATGGGACTGTTGCTAATTCCAAGTATGTA
    ACTGGTGCCTTTTCCGAGTACGACTTATCTAAAGGAGAATTTCCTATCACAACCTTGCGT
    CCCATTGCAATCAAATCCGCCATCAAAGAAGTTCTCTGGATTTACCAAGACCAGTCAAAT
    AGCTTAGAAGTGCTTAATGACAAGTACAATGTTCACTACTGGAATGACTGGGAAGTTGGA
    GACACGGGAACCATTGGTGAGCGCTATGGTGCCGTTGTTAAGAAACACGACATTATCAAT
    AAGCTTCTCAAACAGTTGGAAACCAATCCTTGGAACCGCCGCAATATTATTTCGCTCTGG
    GATTACCAAGCTTTCGAAGAAACAGATGGGCTGCTCCCGTGCGCCTTTCAGACCATGTTT
    GATGTTCGGCGTGTTGATGGGGAAATCTATCTGGATGCGACCTTGACCCAGCGCTCCAAT
    GATATGCTGGTGGCCCACCACATCAACGCTATGCAGTATGTGGCTTTGCAGATGATGATT
    GCCAAACATTTTGGCTGGAAGGTTGGGAAGTTCTTCTACTTCATCAACAACCTCCATATC
    TATGATAATCAATTTGAACAAGCTCAGGAATTGCTCCGTCGGGAGCCGTCAAACTGCCAA
    CCACGCTTGGTTTTAAATGTTCCTGATGGGACTAATTTCTTTGATATCAAAGCAGAAGAT
    TTTGAGTTGGTGGATTATGACCCTGTTAAGCCACAGTTGAAGTTTGACCTAGCTATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_0669 [new locus tag: SP_RS03285 ]
  • symbol: ThyA
  • description: thymidylate synthase
  • length: 279
  • theoretical pI: 5.22377
  • theoretical MW: 32553.8
  • GRAVY: -0.415412

⊟Function[edit | edit source]

  • reaction:
    EC 2.1.1.45?  ExPASy
    Thymidylate synthase 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides 2'-Deoxyribonucleotide metabolism thymidylate synthase (TIGR03284; EC 2.1.1.45; HMM-score: 119.1)
    and 1 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides 2'-Deoxyribonucleotide metabolism thymidylate synthase, methanogen type (TIGR03283; EC 2.1.1.-; HMM-score: 40.4)
  • TheSEED  :
    • Thymidylate synthase (EC 2.1.1.45)
    Cofactors, Vitamins, Prosthetic Groups, Pigments Folate and pterines Folate Biosynthesis  Thymidylate synthase (EC 2.1.1.45)
    and 1 more
    Nucleosides and Nucleotides Pyrimidines pyrimidine conversions  Thymidylate synthase (EC 2.1.1.45)
  • PFAM:
    no clan defined Thymidylat_synt; Thymidylate synthase (PF00303; HMM-score: 213.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.009077
    • TAT(Tat/SPI): 0.000939
    • LIPO(Sec/SPII): 0.001033
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAFSEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDTGTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFDLAI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Tim van Opijnen, Andrew Camilli
    A fine scale phenotype-genotype virulence map of a bacterial pathogen.
    Genome Res: 2012, 22(12);2541-51
    [PubMed:22826510] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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