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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1468 [new locus tag: SP_RS07215 ]
  • pan locus tag?: PNEUPAN002752000
  • symbol: SP_1468
  • pan gene symbol?: pdxS
  • synonym:
  • product: pyridoxine biosynthesis protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1468 [new locus tag: SP_RS07215 ]
  • symbol: SP_1468
  • product: pyridoxine biosynthesis protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1380503..1381378
  • length: 876
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGACTGAAAATCGTTATGAACTAAATAAAAACTTGGCACAGATGCTCAAGGGTGGTGTT
    ATTATGGATGTGCAGAATCCTGAACAGGCTCGTATCGCAGAAGCTGCTGGTGCGGCAGCT
    GTGATGGCCTTGGAACGAATTCCGGCTGATATTCGTGCAGCTGGAGGAGTTTCCCGCATG
    AGCGACCCAAAGATGATTAAGGAAATCCAAGAAGCGGTTAGTATTCCAGTAATGGCTAAG
    GTCAGAATCGGGCATTTTGTTGAAGCTCAGATTTTAGAGGCTATTGAAATTGATTATATC
    GACGAGAGTGAAGTTCTATCTCCAGCTGATGACCGTTTCCATGTGGACAAGAAAGAATTC
    CAAGTTCCTTTTGTCTGTGGTGCTAAGGATTTGGGTGAAGCCTTGCGTCGTATCGCTGAA
    GGTGCTTCCATGATTCGTACCAAAGGAGAACCAGGGACAGGGGATATCGTCCAAGCTGTT
    CGTCATATGCGTATGATGAATCAGGAAATTCGCCGCATTCAAAACTTACGTGAGGACGAG
    CTTTATGTTGCTGCCAAGGATTTGCAAGTCCCTGTAGAATTGGTCCAATATGTTCATGAA
    CATGGAAAATTGCCAGTTGTAAATTTCGCTGCTGGAGGTGTTGCAACGCCAGCAGATGCT
    GCGTTAATGATGCAATTAGGGGCAGAGGGGGTCTTTGTCGGTTCAGGTATTTTCAAGTCA
    GGAGATCCTGTTAAACGAGCGAGTGCCATTGTTAAGGCTGTGACTAACTTCCGTAATCCT
    CAAATCCTAGCTCAAATCTCTGAAGATTTAGGAGAAGCCATGGTTGGTATTAATGAAAAT
    GAAATCCAAATTCTCATGGCTGAACGAGGAAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    876

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1468 [new locus tag: SP_RS07215 ]
  • symbol: SP_1468
  • description: pyridoxine biosynthesis protein
  • length: 291
  • theoretical pI: 5.00076
  • theoretical MW: 31740.5
  • GRAVY: -0.0845361

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridoxine pyridoxal 5'-phosphate synthase, synthase subunit Pdx1 (TIGR00343; HMM-score: 516.6)
    and 9 more
    Unknown function General putative TIM-barrel protein, nifR3 family (TIGR00737; HMM-score: 24.9)
    glycosyl amidation-associated protein WbuZ (TIGR03572; HMM-score: 20)
    Metabolism Amino acid biosynthesis Histidine family imidazoleglycerol phosphate synthase, cyclase subunit (TIGR00735; HMM-score: 18.6)
    dihydroorotate dehydrogenase family protein (TIGR01037; EC 1.3.-.-; HMM-score: 17.6)
    Metabolism Amino acid biosynthesis Histidine family 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (TIGR00007; EC 5.3.1.16; HMM-score: 15.7)
    putative enoyl-[acyl-carrier-protein] reductase II (TIGR03151; EC 1.3.1.-; HMM-score: 14.5)
    3-hexulose-6-phosphate synthase (TIGR03128; EC 4.1.2.43; HMM-score: 14.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiamine-phosphate diphosphorylase (TIGR00693; EC 2.5.1.3; HMM-score: 14.1)
    Unknown function General IMP dehydrogenase family protein (TIGR01304; HMM-score: 12.6)
  • TheSEED  :
    • Pyridoxine biosynthesis glutamine amidotransferase, synthase subunit (EC 2.4.2.-)
    Cofactors, Vitamins, Prosthetic Groups, Pigments Pyridoxine Pyridoxin (Vitamin B6) Biosynthesis  Pyridoxine biosynthesis glutamine amidotransferase, synthase subunit (EC 2.4.2.-)
  • PFAM:
    TIM_barrel (CL0036) SOR_SNZ; SOR/SNZ family (PF01680; HMM-score: 360.8)
    and 12 more
    ThiG; Thiazole biosynthesis protein ThiG (PF05690; HMM-score: 42.6)
    TetR_C (CL0174) TetR_C_27; Tetracyclin repressor-like, C-terminal domain (PF17935; HMM-score: 20.7)
    TIM_barrel (CL0036) NMO; Nitronate monooxygenase (PF03060; HMM-score: 19.5)
    Dus; Dihydrouridine synthase (Dus) (PF01207; HMM-score: 18.5)
    IGPS; Indole-3-glycerol phosphate synthase (PF00218; HMM-score: 18.2)
    His_biosynth; Histidine biosynthesis protein (PF00977; HMM-score: 16.8)
    no clan defined Med10; Transcription factor subunit Med10 of Mediator complex (PF09748; HMM-score: 14.3)
    TIM_barrel (CL0036) IMPDH; IMP dehydrogenase / GMP reductase domain (PF00478; HMM-score: 13.7)
    NanE; Putative N-acetylmannosamine-6-phosphate epimerase (PF04131; HMM-score: 13)
    TMP-TENI; Thiamine monophosphate synthase (PF02581; HMM-score: 12.7)
    no clan defined Milton; Kinesin associated protein (PF12448; HMM-score: 12.6)
    TIM_barrel (CL0036) DHO_dh; Dihydroorotate dehydrogenase (PF01180; HMM-score: 12.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.7154
    • Cytoplasmic Membrane Score: 0.2518
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0327
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.014452
    • TAT(Tat/SPI): 0.019082
    • LIPO(Sec/SPII): 0.000818
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTENRYELNKNLAQMLKGGVIMDVQNPEQARIAEAAGAAAVMALERIPADIRAAGGVSRMSDPKMIKEIQEAVSIPVMAKVRIGHFVEAQILEAIEIDYIDESEVLSPADDRFHVDKKEFQVPFVCGAKDLGEALRRIAEGASMIRTKGEPGTGDIVQAVRHMRMMNQEIRRIQNLREDELYVAAKDLQVPVELVQYVHEHGKLPVVNFAAGGVATPADAALMMQLGAEGVFVGSGIFKSGDPVKRASAIVKAVTNFRNPQILAQISEDLGEAMVGINENEIQILMAERGK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site: 1381412 [1]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ 1.0 1.1 1.2 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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