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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 23-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_RS01405 [old locus tag: SP_0286 ]
  • pan locus tag?: PNEUPAN001024000
  • symbol: SP_RS01405
  • pan gene symbol?: yitU
  • synonym:
  • product: Cof-type HAD-IIB family hydrolase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_RS01405 [old locus tag: SP_0286 ]
  • symbol: SP_RS01405
  • product: Cof-type HAD-IIB family hydrolase
  • replicon: chromosome
  • strand: -
  • coordinates: 264266..265078
  • length: 813
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_003028 (264266..265078) NCBI
  • BioCyc:
  • MicrobesOnline: see SP_0286
  • PneumoBrowse for strain D39V: SPV_0266 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGACGAAAAAAATTATTGCAGTTGACCTGGATGGAACCCTGCTCAACTCAGACAGTCAA
    ATTTCTGACTTTACCAAAAGAACCATCAAAAAAGTTGCTGAAAAAGGCCATCAGGTTATT
    ATTACGACAGGTCGCCCTTACCGTATGTCAAAAGATTTTTACCGTGAACTGGGCTTAGAC
    ACTCCTATGATTAACTTCAACGGATCCCTTACTCATTTACCAGACCAAGTTTGGGATTTT
    GAAAAGTGTTTGACTGTAGACAAAAAATATCTGCTAGATATGGTTCAACGTTCAGAGGAC
    ATTCAAGCCGATTTTATCGCTGGAGAATATCGTAAAAAATTCTACATTACAAATCCCAAT
    GAAGAAATTGCCAATCCCAAACTATTTGGTGTAGAAGCTTTCCAGCCTGAAGATCAATTC
    CAGCCTGAATTGGTGACCAAGGACCCTAACTGTATCCTCTTGCAGACTAGAGCCAGTGAC
    AAATATTCCTTGGCAAAAGAAATGAACGCCTTCTACCAGCATCAACTTTCTATCAATACC
    TGGGGAGGTCCGCTCAATATCCTTGAATGTACCCCAAAAGGTGTCAACAAGGCCTTTGCT
    TTGGACTACTTGCTCAAGATAATGAATCGTGACAAAAAAGATTTGATTGCCTTTGGAGAT
    GAACACAATGATACCGAAATGCTCGCTTTTGCTGGGAAGGGTTATGCCATGAAAAATGCC
    AATCCAGAGCTACTCCCTTATGCAGATGAGCAAATTTCCCTTACCAACGACCAAGATGGG
    GTTGCCAAAACCCTACAAGACTTATTCTTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    813

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_RS01405 [old locus tag: SP_0286 ]
  • symbol: SP_RS01405
  • description: Cof-type HAD-IIB family hydrolase
  • length: 270
  • theoretical pI: 4.9356
  • theoretical MW: 30792.9
  • GRAVY: -0.458889

⊟Function[edit | edit source]

  • reaction:
    EC 3.-.-.-?  ExPASy
  • TIGRFAM:
    Unknown function Enzymes of unknown specificity Cof-like hydrolase (TIGR00099; HMM-score: 178.4)
    and 16 more
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIB (TIGR01484; HMM-score: 91)
    phosphoglycolate phosphatase, TA0175-type (TIGR01487; EC 3.1.3.18; HMM-score: 65.9)
    sucrose-phosphate phosphatase subfamily (TIGR01482; EC 3.1.3.-; HMM-score: 62.4)
    mannosyl-3-phosphoglycerate phosphatase family (TIGR01486; EC 3.1.3.-; HMM-score: 45.9)
    Unknown function General mannosyl-3-phosphoglycerate phosphatase homolog (TIGR02463; EC 3.1.3.-; HMM-score: 40.2)
    mannosyl-3-phosphoglycerate phosphatase (TIGR02461; EC 3.1.3.70; HMM-score: 34.9)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IB (TIGR01490; HMM-score: 33.2)
    sucrose phosphatase (TIGR01485; EC 3.1.3.24; HMM-score: 31.3)
    Unknown function Enzymes of unknown specificity HAD phosphoserine phosphatase-like hydrolase, family IB (TIGR01488; HMM-score: 29)
    sucrose-phosphate synthase, sucrose phosphatase-like domain (TIGR02471; HMM-score: 23.8)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIIA (TIGR01662; HMM-score: 22)
    Metabolism Amino acid biosynthesis Serine family phosphoserine phosphatase SerB (TIGR00338; EC 3.1.3.3; HMM-score: 17.7)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family (TIGR01670; EC 3.1.3.45; HMM-score: 15.7)
    phosphoserine phosphatase-like hydrolase, archaeal (TIGR01491; HMM-score: 13.2)
    pyrimidine 5'-nucleotidase (TIGR01993; EC 3.1.3.5; HMM-score: 12.7)
    plasma-membrane proton-efflux P-type ATPase (TIGR01647; EC 3.6.3.6; HMM-score: 10.4)
  • TheSEED: see SP_0286
  • PFAM:
    HAD (CL0137) Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 204.3)
    and 6 more
    S6PP; Sucrose-6F-phosphate phosphohydrolase (PF05116; HMM-score: 53.9)
    HAD; haloacid dehalogenase-like hydrolase (PF12710; HMM-score: 30.9)
    Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 26.1)
    Trehalose_PPase; Trehalose-phosphatase (PF02358; HMM-score: 18.9)
    HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 14.8)
    no clan defined DUF460; Protein of unknown function (DUF460) (PF04312; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9964
    • Cytoplasmic Membrane Score: 0.0025
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0011
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006626
    • TAT(Tat/SPI): 0.000433
    • LIPO(Sec/SPII): 0.000899
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTKKIIAVDLDGTLLNSDSQISDFTKRTIKKVAEKGHQVIITTGRPYRMSKDFYRELGLDTPMINFNGSLTHLPDQVWDFEKCLTVDKKYLLDMVQRSEDIQADFIAGEYRKKFYITNPNEEIANPKLFGVEAFQPEDQFQPELVTKDPNCILLQTRASDKYSLAKEMNAFYQHQLSINTWGGPLNILECTPKGVNKAFALDYLLKIMNRDKKDLIAFGDEHNDTEMLAFAGKGYAMKNANPELLPYADEQISLTNDQDGVAKTLQDLFL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site: see SP_0286

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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