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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 23-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_RS02790 [old locus tag: SP_0568 ]
  • pan locus tag?: PNEUPAN001450000
  • symbol: SP_RS02790
  • pan gene symbol?: valS
  • synonym:
  • product: valine--tRNA ligase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_RS02790 [old locus tag: SP_0568 ]
  • symbol: SP_RS02790
  • product: valine--tRNA ligase
  • replicon: chromosome
  • strand: +
  • coordinates: 532605..535256
  • length: 2652
  • essential: yes [1]

⊟Accession numbers[edit | edit source]

  • Location: NC_003028 (532605..535256) NCBI
  • BioCyc:
  • MicrobesOnline: see SP_0568
  • PneumoBrowse for strain D39V: SPV_0494 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    ATGTCTAAAGAACTTTCACCTAAATACAATCCAGCCGAGGTTGAGGCTGGTCGTTACCAA
    AAATGGCTTGATGCGGATGTTTTCAAGCCTTCAGGCGATCAAAAGGCTAAGCCTTATTCA
    ATCGTGATTCCACCACCAAACGTAACTGGGAAACTTCACCTTGGTCACGCTTGGGATACG
    ACTTTGCAGGATATCATCATCCGTCAAAAACGCATGCAAGGCTTTGATACCCTTTGGCTT
    CCAGGTATGGACCACGCTGGTATTGCGACTCAGGCTAAGGTTGAGGAGCGCTTACGTGGT
    GAGGGTATTACGCGTTATGACCTAGGTCGTGAGTCTTTCTTGACGAAGGTCTGGGAATGG
    AAAGACGAATATGCCACTACCATCAAGGAACAATGGGGCAAGATGGGGCTTTCTGTAGAC
    TATTCTCGTGAGCGTTTCACTCTTGATGAAGGTTTGTCAAAAGCTGTTCGTAAGGTCTTT
    GTGAACCTTTACAAGAAAGGCTGGATCTATCGTGGTGAGTTTATCATCAACTGGGACCCA
    GCAGCTCGCACAGCCCTTTCTGATATTGAGGTGATTCACAAGGATGTAGAAGGTGCCTTC
    TACCACATGAATTACATGCTGGAAGATGGTTCACGCGCCCTTGAAGTTGCTACAACTCGT
    CCTGAGACTATGTTTGGGGACGTTGCGGTTGCGGTTAATCCAGAAGACCCGCGCTACAAG
    GACTTGATTGGTAAAAACGTCATCCTTCCAATCGCTAATAAACTCATCCCAATCGTTGGA
    GATGAGCACGCAGATCCTGAGCTTGGTACTGGTGTCGTGAAAATCACACCTGCCCACGAT
    CCAAATGACTTCTTGGTTGGCCAACGTCATAACTTGCCACAAGTCAACGTCATGAACGAC
    GACGGAACTATGAATGAGCTTGCCTTTGAATTTTCAGGCATGGATCGTTTTGAAGCTCGT
    AAGGCAGTCGTTGCTAAGTTGGAAGAAATCGGTGCCCTTGTCAAAATCGAAAAACGTGTC
    CACAGTGTTGGTCACTCAGAACGTACAGGTGTCGTAGTTGAGCCACGCTTGTCTACTCAA
    TGGTTCGTCAAGATGGACCAATTGGCTAAGAACGCCATTGCTAACCAAGACACAGAGGAC
    AAGGTCGAATTCTACCCACCTCGTTTCAACGATACCTTCCTTCAATGGATGGAAAATGTC
    CACGACTGGGTTATCTCTCGTCAGCTTTGGTGGGGTCACCAAATCCCTGCCTGGTACAAT
    GCTGATGGTGAAATGTATGTCGGCGAAGAAGCTCCAGAAGGTGACGGATGGACTCAGGAC
    GAAGACGTCTTGGATACTTGGTTCAGTTCTGCCCTCTGGCCATTTTCAACCATGGGCTGG
    CCTGAAGTCGACTCAGAAGACTTTAAACGTTATTTCCCAACTTCAACCTTGGTAACAGGT
    TACGACATCATCTTCTTCTGGGTGTCTCGTATGATCTTCCAGTCCTTGGAATTTACTGGT
    CGTCAGCCATTCCAAAACGTGCTTATCCACGGTCTCATCCGTGACGAGCAAGGACGCAAG
    ATGTCTAAATCTCTCGGTAACGGGATTGACCCAATGGATGTCATCGAGAAATACGGTGCT
    GATGCCCTTCGTTGGTTCCTTTCAAACGGTTCCGCACCAGGTCAAGACGTTCGTTTCTCT
    TACGAGAAAATGGATGCTTCATGGAACTTTATTAACAAAATTTGGAACATTTCTCGCTAT
    ATCCTCATGAACAATGAAGGTTTGACGCTGGATGTGGCGCATGACAATGTCACAAAAGTT
    GCAACAGGTGAGGCTGGTAATGTGACGGACCGCTGGATTCTCCACAATCTCAACGAAACC
    ATTGCAAAAGTTACTGAAAACTTTGATAAGTTCGAGTTTGGTGTGGCTGGTCATATCCTT
    TACAACTTCATCTGGGAAGAATTTGCCAACTGGTATGTTGAGTTGACCAAGGAAGTTCTA
    TACAGCGACAATGAAGACGATAAGGTCATTACTCGATCTGTTCTCCTCTATACGCTGGAC
    AAGATCCTTCGTCTCCTTCACCCAATCATGCCATTCGTGACAGAGGAAATCTTTGGACAA
    ATCTCAGAAGGTTCTATCGTGACAGCTGCATACCCAACTGTTAATCTAGCCTTTGAAGAC
    CTTGCGGCTCACACTGGTGTGGAAAGTCTCAAAGACTTGATTCGTGCTGTTCGGAATGCG
    CGTGCGGAAGTAAATGTAGCACCAAGCAAGCCTATCACCATCCTTGTTAAGACAAGCGAT
    AGCGACTTGGAAGCCTTCTTTAACAGCAATGTCAACTATATCAAACGCTTTACAAATCCA
    GAACACTTGGAAATCGCATCAACCATCCCTGCACCTGAACTGGCTATGTCAAGTGTCATC
    ACAGGAGCAGAAATCTACCTGCCACTGGCCGATCTCCTCAATGTTGAAGAAGAACTGGCC
    CGTCTCGACAAGGAACTTGCTAAATGGCAAAAAGAACTGGACATGGTTGGTAAGAAACTC
    TCTAACGAACGCTTCGTAGCCAACGCCAAACCAGAAGTCGTCCAAAAAGAATGCGACAAA
    CAAGCTGACTACCAAGCTAAATATGACGCGACCGTCGCACGTATTGATGAGATGAAGAAG
    TTGGTGAAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2652

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_RS02790 [old locus tag: SP_0568 ]
  • symbol: SP_RS02790
  • description: valine--tRNA ligase
  • length: 883
  • theoretical pI: 4.79674
  • theoretical MW: 100775
  • GRAVY: -0.356399

⊟Function[edit | edit source]

  • reaction:
    EC 6.1.1.9?  ExPASy
    Valine--tRNA ligase ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)
  • TIGRFAM:
    Genetic information processing Protein synthesis tRNA aminoacylation valine--tRNA ligase (TIGR00422; EC 6.1.1.9; HMM-score: 1146.3)
    and 6 more
    Genetic information processing Protein synthesis tRNA aminoacylation isoleucine--tRNA ligase (TIGR00392; EC 6.1.1.5; HMM-score: 415.9)
    Genetic information processing Protein synthesis tRNA aminoacylation leucine--tRNA ligase (TIGR00395; EC 6.1.1.4; HMM-score: 199.2)
    Genetic information processing Protein synthesis tRNA aminoacylation leucine--tRNA ligase (TIGR00396; EC 6.1.1.4; HMM-score: 173.6)
    Genetic information processing Protein synthesis tRNA aminoacylation methionine--tRNA ligase (TIGR00398; EC 6.1.1.10; HMM-score: 137.2)
    Genetic information processing Protein synthesis tRNA aminoacylation cysteine--tRNA ligase (TIGR00435; EC 6.1.1.16; HMM-score: 29.8)
    Genetic information processing Protein synthesis tRNA aminoacylation arginine--tRNA ligase (TIGR00456; EC 6.1.1.19; HMM-score: 12.4)
  • TheSEED: see SP_0568
  • PFAM:
    HUP (CL0039) tRNA-synt_1; tRNA synthetases class I (I, L, M and V) (PF00133; HMM-score: 690.1)
    and 9 more
    DALR (CL0258) Anticodon_1; Anticodon-binding domain of tRNA ligase (PF08264; HMM-score: 139.8)
    HUP (CL0039) tRNA-synt_1g; tRNA synthetases class I (M) (PF09334; HMM-score: 100.8)
    tRNA_bind_arm (CL0298) Val_tRNA-synt_C; Valyl tRNA synthetase tRNA binding arm (PF10458; HMM-score: 59.7)
    HUP (CL0039) tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2 (PF13603; HMM-score: 30.8)
    tRNA-synt_1e; tRNA synthetases class I (C) catalytic domain (PF01406; HMM-score: 28.5)
    tRNA-synt_1f; tRNA synthetases class I (K) (PF01921; HMM-score: 19.5)
    no clan defined Gemini_AL1_M; Geminivirus rep protein central domain (PF08283; HMM-score: 13.7)
    DUF3849; Protein of unknown function (DUF3849) (PF12960; HMM-score: 12.9)
    Focal_AT; Focal adhesion targeting region (PF03623; HMM-score: 12.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9971
    • Cytoplasmic Membrane Score: 0
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0029
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.010042
    • TAT(Tat/SPI): 0.000514
    • LIPO(Sec/SPII): 0.001585
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSKELSPKYNPAEVEAGRYQKWLDADVFKPSGDQKAKPYSIVIPPPNVTGKLHLGHAWDTTLQDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEERLRGEGITRYDLGRESFLTKVWEWKDEYATTIKEQWGKMGLSVDYSRERFTLDEGLSKAVRKVFVNLYKKGWIYRGEFIINWDPAARTALSDIEVIHKDVEGAFYHMNYMLEDGSRALEVATTRPETMFGDVAVAVNPEDPRYKDLIGKNVILPIANKLIPIVGDEHADPELGTGVVKITPAHDPNDFLVGQRHNLPQVNVMNDDGTMNELAFEFSGMDRFEARKAVVAKLEEIGALVKIEKRVHSVGHSERTGVVVEPRLSTQWFVKMDQLAKNAIANQDTEDKVEFYPPRFNDTFLQWMENVHDWVISRQLWWGHQIPAWYNADGEMYVGEEAPEGDGWTQDEDVLDTWFSSALWPFSTMGWPEVDSEDFKRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTGRQPFQNVLIHGLIRDEQGRKMSKSLGNGIDPMDVIEKYGADALRWFLSNGSAPGQDVRFSYEKMDASWNFINKIWNISRYILMNNEGLTLDVAHDNVTKVATGEAGNVTDRWILHNLNETIAKVTENFDKFEFGVAGHILYNFIWEEFANWYVELTKEVLYSDNEDDKVITRSVLLYTLDKILRLLHPIMPFVTEEIFGQISEGSIVTAAYPTVNLAFEDLAAHTGVESLKDLIRAVRNARAEVNVAPSKPITILVKTSDSDLEAFFNSNVNYIKRFTNPEHLEIASTIPAPELAMSSVITGAEIYLPLADLLNVEEELARLDKELAKWQKELDMVGKKLSNERFVANAKPEVVQKECDKQADYQAKYDATVARIDEMKKLVK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Tim van Opijnen, Andrew Camilli
    A fine scale phenotype-genotype virulence map of a bacterial pathogen.
    Genome Res: 2012, 22(12);2541-51
    [PubMed:22826510] [WorldCat.org] [DOI] (I p)
  2. ↑ 2.0 2.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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