From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 23-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_RS07470 [old locus tag: SP_1517 ]
  • pan locus tag?: PNEUPAN002800000
  • symbol: greA
  • pan gene symbol?: greA
  • synonym:
  • product: transcription elongation factor GreA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_RS07470 [old locus tag: SP_1517 ]
  • symbol: greA
  • product: transcription elongation factor GreA
  • replicon: chromosome
  • strand: -
  • coordinates: 1424808..1425290
  • length: 483
  • essential: yes [1] DEG

⊟Accession numbers[edit | edit source]

  • Location: NC_003028 (1424808..1425290) NCBI
  • BioCyc:
  • MicrobesOnline: see SP_1517
  • PneumoBrowse for strain D39V: SPV_1345 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGGCAGAAAAAACATATCCTATGACCCTTGAGGAAAAGGAAAAACTTGAAAAAGAATTA
    GAAGAATTGAAATTGGTTCGTCGACCAGAAGTGGTAGAACGCATTAAGATTGCCCGTTCA
    TACGGTGACCTTTCAGAAAACAGTGAGTACGAAGCAGCTAAGGATGAACAAGCCTTTGTC
    GAAGGACAAATCTCTAGCTTAGAAACAAAAATCCGCTATGCTGAAATCGTCAATAGCGAC
    GCAGTTGCCCAGGACGAAGTAGCGATTGGTAAAACAGTCACCATCCAAGAAATTGGTGAG
    GACGAAGAAGAAGTTTATATTATCGTAGGTTCAGCTGGTGCAGATGCCTTTGTAGGTAAG
    GTTTCAAATGAAAGCCCAATTGGGCAGGCCTTGATTGGCAAGAAAACAGGTGATACAGCA
    ACCATTGAAACGCCTGTTGGTAGCTATGATGTAAAAATCTTGAAGGTTGAAAAAACAGCC
    TAA
    60
    120
    180
    240
    300
    360
    420
    480
    483

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_RS07470 [old locus tag: SP_1517 ]
  • symbol: GreA
  • description: transcription elongation factor GreA
  • length: 160
  • theoretical pI: 4.2199
  • theoretical MW: 17571.6
  • GRAVY: -0.40625

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Transcription Transcription factors transcription elongation factor GreA (TIGR01462; HMM-score: 185.8)
    and 1 more
    Genetic information processing Transcription Transcription factors transcription elongation factor GreB (TIGR01461; HMM-score: 84)
  • TheSEED: see SP_1517
  • PFAM:
    no clan defined GreA_GreB_N; Transcription elongation factor, N-terminal (PF03449; HMM-score: 94.9)
    FKBP (CL0487) GreA_GreB; Transcription elongation factor, GreA/GreB, C-term (PF01272; HMM-score: 87.5)
    and 2 more
    BET (CL0665) BET; Bromodomain extra-terminal - transcription regulation (PF17035; HMM-score: 14.7)
    OB (CL0021) DNA_ligase_OB; NAD-dependent DNA ligase OB-fold domain (PF03120; HMM-score: 13.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9969
    • Cytoplasmic Membrane Score: 0.0002
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0028
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002695
    • TAT(Tat/SPI): 0.000623
    • LIPO(Sec/SPII): 0.000571
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MAEKTYPMTLEEKEKLEKELEELKLVRRPEVVERIKIARSYGDLSENSEYEAAKDEQAFVEGQISSLETKIRYAEIVNSDAVAQDEVAIGKTVTIQEIGEDEEEVYIIVGSAGADAFVGKVSNESPIGQALIGKKTGDTATIETPVGSYDVKILKVEKTA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
    Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
    Nucleic Acids Res: 2002, 30(14);3152-62
    [PubMed:12136097] [WorldCat.org] [DOI] (I p)    Tim van Opijnen, Andrew Camilli
    A fine scale phenotype-genotype virulence map of a bacterial pathogen.
    Genome Res: 2012, 22(12);2541-51
    [PubMed:22826510] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SP_RS07470&oldid=1458"