⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 30-JAN-2014

⊟Summary

• organism: Streptococcus pneumoniae G54
locus tag: SPG_1902 [new locus tag: SPG_RS09515 ]
pan locus tag^?: PNEUPAN003546000
symbol: SPG_1902
pan gene symbol^?: rr11
• synonym:
• product: response regulator TCS11

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPG_1902 [new locus tag: SPG_RS09515 ]
• symbol: SPG_1902
• product: response regulator TCS11
• replicon: chromosome
• strand: -
• coordinates: 1813879..1814478
• length: 600
• essential: unknown

⊟Accession numbers

• Location: CP001015 (1813879..1814478) NCBI
• BioCyc: see SPG_RS09515
• MicrobesOnline: 5757169 MicrobesOnline
• PneumoBrowse for strain D39V: SPV_1798 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
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  481
  541
  
  ATGAAAGTATTAGTCGCAGAAGATCAAAGTATGTTGCGAGATGCCATGTGTCAATTGCTC
  ACGCTTCAACCAGATGTGGAGTCTGTCCTTCAAGCCAAGAATGGGCAAGAAGCAATCCAA
  CTATTAGAAAAGGAGTCTGTAGATATCGCCATCCTTGACGTAGAAATGCCTGTTAAGACA
  GGTCTTGAAGTCTTGGAGTGGATACGATCAGAAAGGCTTGAAACAAAGGTGGTTGTGGTG
  ACGACCTTCAAGCGTGCTGGGTATTTTGAACGTGCGGTCAAGGCTGGAGTGGATGCTTAT
  GTATTAAAGGAACGAAGCGTTGCAGACCTCATGCAAACCTTGCACACCGTCCTCGAAGGA
  CGCAAGGAGTATTCGCCTGAATTGATGGAAGTGGTGATGACCCGTCCCAATCCGTTGACA
  GAACAAGAGATTGCTGTCTTAAAGGGGATCGCCCGGGGCTTATCCAACCAAGAAATCGCA
  GATCAGCTTTACCTCTCAAACGGAACTATTCGAAACTATGTCACCAATATTCTTTCAAAA
  TTGGATGCTGGTAATCGAACAGAGGCAGCTAATATCGCAAAAGAATCTGGTTGGTTATGA
  60
  120
  180
  240
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  360
  420
  480
  540
  600
  

⊟Protein

⊟General

• locus tag: SPG_1902 [new locus tag: SPG_RS09515 ]
• symbol: SPG_1902
• description: response regulator TCS11
• length: 199
• theoretical pI: 4.65392
• theoretical MW: 22247.5
• GRAVY: -0.120603

⊟Function

• ⊞⊞TIGRFAM:
  Cellular processes Cellular processes Sporulation and germination sporulation transcription factor Spo0A (TIGR02875; HMM-score: 61.1)
  and 15 more
  Signal transduction Regulatory functions DNA interactions phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 43)
  Signal transduction Signal transduction Two-component systems phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 43)
  Signal transduction Regulatory functions DNA interactions heavy metal response regulator (TIGR01387; HMM-score: 41.3)
  transcriptional regulator EpsA (TIGR03020; HMM-score: 41)
  Metabolism Central intermediary metabolism Nitrogen metabolism nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 31.9)
  Signal transduction Regulatory functions DNA interactions nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 31.9)
  Signal transduction Signal transduction Two-component systems nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 31.9)
  Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 31.5)
  LuxR family transcriptional regulatory, chaperone HchA-associated (TIGR03541; HMM-score: 23.7)
  RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 20.6)
  proteobacterial dedicated sortase system response regulator (TIGR03787; HMM-score: 20.2)
  RNA polymerase sigma-70 factor, Bacteroides expansion family 1 (TIGR02985; HMM-score: 19.4)
  Signal transduction Regulatory functions DNA interactions CRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 18.4)
  Signal transduction Regulatory functions DNA interactions PEP-CTERM-box response regulator transcription factor (TIGR02915; HMM-score: 16.2)
  Signal transduction Regulatory functions DNA interactions DNA-binding protein, Tfx family (TIGR00721; HMM-score: 13.4)
• TheSEED  :
  • Two-component response regulator
• ⊞⊞PFAM:
  CheY (CL0304) Response_reg; Response regulator receiver domain (PF00072; HMM-score: 86.7)
  and 10 more
  HTH (CL0123) GerE; Bacterial regulatory proteins, luxR family (PF00196; HMM-score: 65.7)
  CheY (CL0304) cREC_REC; Cyclic-phosphate processing Receiver domain (PF20274; HMM-score: 21.3)
  HTH (CL0123) Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 17.9)
  HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 17.8)
  HTH_11; HTH domain (PF08279; HMM-score: 15.9)
  HTH_38; Helix-turn-helix domain (PF13936; HMM-score: 15.3)
  PBP (CL0177) LysR_substrate; LysR substrate binding domain (PF03466; HMM-score: 14.7)
  HTH (CL0123) Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 14.3)
  HTH_40; Helix-turn-helix domain (PF14493; HMM-score: 13.8)
  HTH_10; HTH DNA binding domain (PF04967; HMM-score: 12)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.003965
  • TAT(Tat/SPI): 0.000206
  • LIPO(Sec/SPII): 0.000541
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: ACF56283 NCBI
• UniProt:

⊟Protein sequence

• MKVLVAEDQSMLRDAMCQLLTLQPDVESVLQAKNGQEAIQLLEKESVDIAILDVEMPVKTGLEVLEWIRSERLETKVVVVTTFKRAGYFERAVKAGVDAYVLKERSVADLMQTLHTVLEGRKEYSPELMEVVMTRPNPLTEQEIAVLKGIARGLSNQEIADQLYLSNGTIRNYVTNILSKLDAGNRTEAANIAKESGWL

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: SPG_1902 < SPG_1903 < SPG_1904 < SPG_1905 < SPG_1906 < SPG_1907

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1798 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications

Wolfgang Haas, Deepak Kaushal, Jack Sublett, Caroline Obert, Elaine I Tuomanen
Vancomycin stress response in a sensitive and a tolerant strain of Streptococcus pneumoniae.
J Bacteriol: 2005, 187(23);8205-10
[PubMed:16291696] [WorldCat.org] [DOI] (P p)Riana Cockeran, Jenny A Herbert, Timothy J Mitchell, Thérèse Dix-Peek, Caroline Dickens, Ronald Anderson, Charles Feldman
Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11).
Biomed Res Int: 2014, 2014;976347
[PubMed:25013815] [WorldCat.org] [DOI] (I p)