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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

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⊟Summary[edit | edit source]

Contents

  • 1 Summary
  • 2 Genome View
  • 3 Gene
    • 3.1 General
    • 3.2 Accession numbers
    • 3.3 Phenotype
    • 3.4 DNA sequence
  • 4 Protein
    • 4.1 General
    • 4.2 Function
    • 4.3 Structure, modifications & cofactors
    • 4.4 Localization
    • 4.5 Accession numbers
    • 4.6 Protein sequence
    • 4.7 Experimental data
  • 5 Expression & Regulation
    • 5.1 Operon
    • 5.2 Regulation
    • 5.3 Expression data
  • 6 Biological Material
    • 6.1 Mutants
    • 6.2 Expression vector
    • 6.3 lacZ fusion
    • 6.4 GFP fusion
    • 6.5 two-hybrid system
    • 6.6 FLAG-tag construct
    • 6.7 Antibody
  • 7 Other Information
  • 8 Literature
    • 8.1 References
    • 8.2 Relevant publications
  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_0904 [new locus tag: SPG_RS04560 ]
  • pan locus tag?: PNEUPAN001981000
  • symbol: SPG_0904
  • pan gene symbol?: prsA
  • synonym:
  • product: foldase protein PrsA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_0904 [new locus tag: SPG_RS04560 ]
  • symbol: SPG_0904
  • product: foldase protein PrsA
  • replicon: chromosome
  • strand: +
  • coordinates: 873401..874060
  • length: 660
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: CP001015 (873401..874060) NCBI
  • BioCyc: see SPG_RS04560
  • MicrobesOnline: 5756173 MicrobesOnline
  • PneumoBrowse for strain D39V: SPV_0868 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGAAGAAAAAATTATTGGCAGGTGCCATCACACTATTATCAGTAGCAACTTTAGCAGCT
    TGTTCGAAAGGGTCAGAAGGAGCAGACCTTATCAGCATGAAAGGGGATGTCATCACAGAA
    CATCAATTTTATGAGCAAGTGAAAAACAACCCTTCAGCCCAACAAGTCTTGTTAAATATG
    ACCATCCAAAAAGTTTTTGAAAAACAATATGGCTCAGAGCTTGATGATAAAGAGGTTGAT
    GATACTATTGCCGAAGAAAAAAAACAATATGGCGAAAACTACCAACGTGTCTTGTCACAA
    GCAGGTATGACTCTTGAAACACGTAAAGCTCAAATTCGTACAAGTAAATTAGTTGAGTTG
    GCAGTTAAGAAGGTAGCAGAAGCTGAATTGACAGATGAAGCCTATAAGAAAGCCTTTGAT
    GAGTACACTCCAGATGTAACGGCTCAAATCATCCGTCTTAATAATGAAGATAAGGCCAAA
    GAAGTTCTCGAAAAAGCCAAGGCAGTAGGTGCTGATTTTGCTCTATTAGCCAAAGATAAT
    TCAACTGATGAAAAAACAAAAGAAAATGGTGGAGAAATTACCTTTGATTCTGCTTCAACA
    GAAGTACCTGAGCAAGTCGAGAGGAGCCGCTTTCGCTGTAGATGTGGATGGTGTGTCTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_0904 [new locus tag: SPG_RS04560 ]
  • symbol: SPG_0904
  • description: foldase protein PrsA
  • length: 219
  • theoretical pI: 4.8565
  • theoretical MW: 24383.4
  • GRAVY: -0.556621

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 5.2.1.8?  ExPASy
    Peptidylprolyl isomerase Peptidylproline (omega=180) = peptidylproline (omega=0)
  • TIGRFAM:
    aromatic cluster surface protein (TIGR04313; HMM-score: 15.7)
  • TheSEED  :
    • Putative parvulin type peptidyl-prolyl isomerase, similarity with PrsA foldase
    Protein Metabolism Protein folding Peptidyl-prolyl cis-trans isomerase  Putative parvulin type peptidyl-prolyl isomerase, similarity with PrsA foldase
  • ⊞PFAM:
    FKBP (CL0487) Rotamase_3; PPIC-type PPIASE domain (PF13616; HMM-score: 28.8)
    Rotamase; PPIC-type PPIASE domain (PF00639; HMM-score: 25.9)
    and 4 more
    no clan defined DUF4823; Domain of unknown function (DUF4823) (PF16105; HMM-score: 22.5)
    Trigger_C (CL0262) Trigger_C; Bacterial trigger factor protein (TF) C-terminus (PF05698; HMM-score: 17.4)
    SurA_N; SurA N-terminal domain (PF09312; HMM-score: 14.5)
    SurA_N_3; SurA N-terminal domain (PF13624; HMM-score: 14.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.05
    • Cytoplasmic Membrane Score: 8.78
    • Cellwall Score: 0.08
    • Extracellular Score: 0.09
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0001
    • Cytoplasmic Membrane Score: 0.8552
    • Cell wall & surface Score: 0.0099
    • Extracellular Score: 0.1349
  • ⊞SignalP: Signal peptide LIPO(Sec/SPII) length 20 aa
    • SP(Sec/SPI): 0.006396
    • TAT(Tat/SPI): 0.000048
    • LIPO(Sec/SPII): 0.993393
    • Cleavage Site: CS pos: 20-21. LAA-CS. Pr: 0.9939
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACF55717 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFYEQVKNNPSAQQVLLNMTIQKVFEKQYGSELDDKEVDDTIAEEKKQYGENYQRVLSQAGMTLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLNNEDKAKEVLEKAKAVGADFALLAKDNSTDEKTKENGGEITFDSASTEVPEQVERSRFRCRCGWCV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

  • MicrobesOnline: secG > rnr > SPG_0899 > tehB > coiA > pepB > SPG_0903 > SPG_0904 > SPG_0905 > SPG_0906

⊟Regulation[edit | edit source]

  • data available for D39, D39V

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V: SPV_0868 PneumoExpress

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

K Overweg, A Kerr, M Sluijter, M H Jackson, T J Mitchell, A P de Jong, R de Groot, P W Hermans
The putative proteinase maturation protein A of Streptococcus pneumoniae is a conserved surface protein with potential to elicit protective immune responses.
Infect Immun: 2000, 68(7);4180-8
[PubMed:10858235] [WorldCat.org] [DOI] (P p)L E Cron, H J Bootsma, N Noske, P Burghout, S Hammerschmidt, P W M Hermans
Surface-associated lipoprotein PpmA of Streptococcus pneumoniae is involved in colonization in a strain-specific manner.
Microbiology (Reading): 2009, 155(Pt 7);2401-2410
[PubMed:19389773] [WorldCat.org] [DOI] (P p)

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SPG_0904&oldid=73891"
  • This page was last edited on 20 January 2022, at 14:53.
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