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From PneumoWiki
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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr0185 [new locus tag: SPR_RS00995 ]
  • pan locus tag?: PNEUPAN000957000
  • symbol: nrdG
  • pan gene symbol?: nrdG
  • synonym:
  • product: NrdD activating enzyme, generating glycyl radical

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr0185 [new locus tag: SPR_RS00995 ]
  • symbol: nrdG
  • product: NrdD activating enzyme, generating glycyl radical
  • replicon: chromosome
  • strand: +
  • coordinates: 194080..194670
  • length: 591
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGAATAATCCAAAACCACAAGAATGGAAAAGCGAGGAACTTAGTCAAGGTCGTATCATT
    GACTACAAGGCCTTTAACTTTGTGGACGGCGAAGGCGTGCGCAACTCTCTCTATGTATCA
    GGCTGTATGTTTCACTGCGAGGGATGTTATAATGTTGCGACTTGGTCTTTTAATGCTGGC
    ATTCCCTATACAGCAGAATTAGAAGAGCAGATTATGGCAGACCTTGCCCAACCCTATGTT
    CAAGGCTTGACTTTGCTGGGAGGGGAGCCTTTTCTCAATACTGGCATTCTCTTGCCTCTA
    GTTAAACGCATCCGAAAGGAATTGCCAGACAAGGACATTTGGTCCTGGACGGGCTACACT
    TGGGAAGAAATGATGTTGGAAACTCCAGATAAACTGGAACTCTTATCATTGATTGACATT
    CTTGTCGATGGAAGATATGATCGAACTAAGAGAAATCTCATGCTCCAGTTTCGAGGTTCG
    TCCAACCAACGAATTATCGATGTGCAAAAATCGCTCAAAAGTGGGCAAGTAGTGATTTGG
    GACAAGCTCAATGACGGAAAAGAAAGCTATGAACAGGTGAAGAGAGAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    591

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr0185 [new locus tag: SPR_RS00995 ]
  • symbol: NrdG
  • description: NrdD activating enzyme, generating glycyl radical
  • length: 196
  • theoretical pI: 4.71159
  • theoretical MW: 22634.7
  • GRAVY: -0.458673

⊟Function[edit | edit source]

  • ⊞⊞TIGRFAM:
    Genetic information processing Protein fate Protein modification and repair anaerobic ribonucleoside-triphosphate reductase activating protein (TIGR02491; EC 1.97.1.-; HMM-score: 198.5)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides 2'-Deoxyribonucleotide metabolism anaerobic ribonucleoside-triphosphate reductase activating protein (TIGR02491; EC 1.97.1.-; HMM-score: 198.5)
    and 13 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides 2'-Deoxyribonucleotide metabolism anaerobic ribonucleoside-triphosphate reductase activating protein (TIGR02826; EC 1.97.1.-; HMM-score: 50.6)
    Genetic information processing Protein fate Protein modification and repair pyruvate formate-lyase 1-activating enzyme (TIGR02493; EC 1.97.1.4; HMM-score: 48)
    Metabolism Energy metabolism Anaerobic pyruvate formate-lyase 1-activating enzyme (TIGR02493; EC 1.97.1.4; HMM-score: 48)
    glycyl-radical enzyme activating protein (TIGR02494; EC 1.97.1.-; HMM-score: 34.2)
    Genetic information processing Protein fate Protein modification and repair glycine radical enzyme activase, YjjW family (TIGR04041; EC 1.97.1.-; HMM-score: 33.9)
    Genetic information processing Protein fate Protein modification and repair anaerobic ribonucleoside-triphosphate reductase activating protein (TIGR02495; EC 1.97.-.-; HMM-score: 27.8)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides 2'-Deoxyribonucleotide metabolism anaerobic ribonucleoside-triphosphate reductase activating protein (TIGR02495; EC 1.97.-.-; HMM-score: 27.8)
    Genetic information processing Protein synthesis tRNA and rRNA base modification putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE (TIGR03963; HMM-score: 22.1)
    Metabolism Energy metabolism Amino acids and amines choline TMA-lyase-activating enzyme (TIGR04395; EC 1.97.-.-; HMM-score: 21.3)
    Genetic information processing Protein fate Protein modification and repair [benzylsuccinate synthase]-activating enzyme (TIGR04003; EC 1.97.-.-; HMM-score: 17)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin heme d1 biosynthesis radical SAM protein NirJ (TIGR04051; HMM-score: 14.3)
    His-Xaa-Ser system radical SAM maturase HxsC (TIGR03977; HMM-score: 13.7)
    putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE (TIGR04349; HMM-score: 12.4)
  • TheSEED  :
    • Anaerobic ribonucleoside-triphosphate reductase-activating protein
    Nucleosides and Nucleotides Nucleosides and Nucleotides - no subcategory Ribonucleotide reduction  Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
  • ⊞⊞PFAM:
    4Fe-4S (CL0344) Fer4_12; 4Fe-4S single cluster domain (PF13353; HMM-score: 172.8)
    and 2 more
    Fer4_14; 4Fe-4S single cluster domain (PF13394; HMM-score: 103.4)
    TIM_barrel (CL0036) Radical_SAM; Radical SAM superfamily (PF04055; HMM-score: 24.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • ⊞⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.249824
    • TAT(Tat/SPI): 0.001033
    • LIPO(Sec/SPII): 0.004118
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNNPKPQEWKSEELSQGRIIDYKAFNFVDGEGVRNSLYVSGCMFHCEGCYNVATWSFNAGIPYTAELEEQIMADLAQPYVQGLTLLGGEPFLNTGILLPLVKRIRKELPDKDIWSWTGYTWEEMMLETPDKLELLSLIDILVDGRYDRTKRNLMLQFRGSSNQRIIDVQKSLKSGQVVIWDKLNDGKESYEQVKRE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • ⊞⊞regulator: NrdR* (repression) regulon

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=spr0185&oldid=128838"
Insert paragraph

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr0185 [new locus tag: SPR_RS00995 ]
  • pan locus tag?: PNEUPAN000957000
  • symbol: nrdG
  • pan gene symbol?: nrdG
  • synonym:
  • product: NrdD activating enzyme, generating glycyl radical

Insert paragraph

⊟Genome View[edit | edit source]

Insert paragraph

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr0185 [new locus tag: SPR_RS00995 ]
  • symbol: nrdG
  • product: NrdD activating enzyme, generating glycyl radical
  • replicon: chromosome
  • strand: +
  • coordinates: 194080..194670
  • length: 591
  • essential: unknown

Insert paragraph

⊟Accession numbers[edit | edit source]

Insert paragraph

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGAATAATCCAAAACCACAAGAATGGAAAAGCGAGGAACTTAGTCAAGGTCGTATCATT
    GACTACAAGGCCTTTAACTTTGTGGACGGCGAAGGCGTGCGCAACTCTCTCTATGTATCA
    GGCTGTATGTTTCACTGCGAGGGATGTTATAATGTTGCGACTTGGTCTTTTAATGCTGGC
    ATTCCCTATACAGCAGAATTAGAAGAGCAGATTATGGCAGACCTTGCCCAACCCTATGTT
    CAAGGCTTGACTTTGCTGGGAGGGGAGCCTTTTCTCAATACTGGCATTCTCTTGCCTCTA
    GTTAAACGCATCCGAAAGGAATTGCCAGACAAGGACATTTGGTCCTGGACGGGCTACACT
    TGGGAAGAAATGATGTTGGAAACTCCAGATAAACTGGAACTCTTATCATTGATTGACATT
    CTTGTCGATGGAAGATATGATCGAACTAAGAGAAATCTCATGCTCCAGTTTCGAGGTTCG
    TCCAACCAACGAATTATCGATGTGCAAAAATCGCTCAAAAGTGGGCAAGTAGTGATTTGG
    GACAAGCTCAATGACGGAAAAGAAAGCTATGAACAGGTGAAGAGAGAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    591

Insert paragraph

This data comes from external databases and cannot be edited.

Insert paragraph

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr0185 [new locus tag: SPR_RS00995 ]
  • symbol: NrdG
  • description: NrdD activating enzyme, generating glycyl radical
  • length: 196
  • theoretical pI: 4.71159
  • theoretical MW: 22634.7
  • GRAVY: -0.458673

Insert paragraph

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Genetic information processing Protein fate Protein modification and repair anaerobic ribonucleoside-triphosphate reductase activating protein (TIGR02491; EC 1.97.1.-; HMM-score: 198.5)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides 2'-Deoxyribonucleotide metabolism anaerobic ribonucleoside-triphosphate reductase activating protein (TIGR02491; EC 1.97.1.-; HMM-score: 198.5)
    and 13 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides 2'-Deoxyribonucleotide metabolism anaerobic ribonucleoside-triphosphate reductase activating protein (TIGR02826; EC 1.97.1.-; HMM-score: 50.6)
    Genetic information processing Protein fate Protein modification and repair pyruvate formate-lyase 1-activating enzyme (TIGR02493; EC 1.97.1.4; HMM-score: 48)
    Metabolism Energy metabolism Anaerobic pyruvate formate-lyase 1-activating enzyme (TIGR02493; EC 1.97.1.4; HMM-score: 48)
    glycyl-radical enzyme activating protein (TIGR02494; EC 1.97.1.-; HMM-score: 34.2)
    Genetic information processing Protein fate Protein modification and repair glycine radical enzyme activase, YjjW family (TIGR04041; EC 1.97.1.-; HMM-score: 33.9)
    Genetic information processing Protein fate Protein modification and repair anaerobic ribonucleoside-triphosphate reductase activating protein (TIGR02495; EC 1.97.-.-; HMM-score: 27.8)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides 2'-Deoxyribonucleotide metabolism anaerobic ribonucleoside-triphosphate reductase activating protein (TIGR02495; EC 1.97.-.-; HMM-score: 27.8)
    Genetic information processing Protein synthesis tRNA and rRNA base modification putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE (TIGR03963; HMM-score: 22.1)
    Metabolism Energy metabolism Amino acids and amines choline TMA-lyase-activating enzyme (TIGR04395; EC 1.97.-.-; HMM-score: 21.3)
    Genetic information processing Protein fate Protein modification and repair [benzylsuccinate synthase]-activating enzyme (TIGR04003; EC 1.97.-.-; HMM-score: 17)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin heme d1 biosynthesis radical SAM protein NirJ (TIGR04051; HMM-score: 14.3)
    His-Xaa-Ser system radical SAM maturase HxsC (TIGR03977; HMM-score: 13.7)
    putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE (TIGR04349; HMM-score: 12.4)
  • TheSEED  :
    • Anaerobic ribonucleoside-triphosphate reductase-activating protein
    Nucleosides and Nucleotides Nucleosides and Nucleotides - no subcategory Ribonucleotide reduction  Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
  • ⊞PFAM:
    4Fe-4S (CL0344) Fer4_12; 4Fe-4S single cluster domain (PF13353; HMM-score: 172.8)
    and 2 more
    Fer4_14; 4Fe-4S single cluster domain (PF13394; HMM-score: 103.4)
    TIM_barrel (CL0036) Radical_SAM; Radical SAM superfamily (PF04055; HMM-score: 24.8)

Insert paragraph

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Insert paragraph

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.249824
    • TAT(Tat/SPI): 0.001033
    • LIPO(Sec/SPII): 0.004118
  • predicted transmembrane helices (TMHMM): 0

Insert paragraph

⊟Accession numbers[edit | edit source]

Insert paragraph

⊟Protein sequence[edit | edit source]

  • MNNPKPQEWKSEELSQGRIIDYKAFNFVDGEGVRNSLYVSGCMFHCEGCYNVATWSFNAGIPYTAELEEQIMADLAQPYVQGLTLLGGEPFLNTGILLPLVKRIRKELPDKDIWSWTGYTWEEMMLETPDKLELLSLIDILVDGRYDRTKRNLMLQFRGSSNQRIIDVQKSLKSGQVVIWDKLNDGKESYEQVKRE

Insert paragraph

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Insert paragraph

⊟Expression & Regulation[edit | edit source]

Insert paragraph

⊟Operon[edit | edit source]

Insert paragraph

⊟Regulation[edit | edit source]

  • ⊞regulator: NrdR* (repression) regulon

Insert paragraph

⊟Expression data[edit | edit source]

Insert paragraph

⊞Biological Material[edit | edit source]

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

⊞Other Information[edit | edit source]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

Insert paragraph

⊟Relevant publications[edit | edit source]

Insert paragraph