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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
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serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1557 [new locus tag: SPR_RS07725 ]
  • pan locus tag?: PNEUPAN003117000
  • symbol: spr1557
  • pan gene symbol?: nrdR
  • synonym:
  • product: Conserved hypothetical protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1557 [new locus tag: SPR_RS07725 ]
  • symbol: spr1557
  • product: Conserved hypothetical protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1538258..1538791
  • length: 534
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    TTGTTTTGGGAATCGCTTAAAAAATGGTATAATGAAAAGAAAACGATAAGGAGGGAAAGG
    ATGCGTTGTCCAAAATGTGGGGCTACCAAGTCAAGTGTTATCGATAGTCGCCAAGCAGAA
    GAAGGGAACACCATTCGTAGAAGACGTGAGTGCGACGAATGCCAACACCGTTTTACAACC
    TACGAACGAGTAGAAGAAAGAACCTTAGTGGTTGTTAAAAAAGATGGCACACGGGAACAA
    TTCTCCAGAGATAAAATCTTTAATGGGATTATCCGCTCAGCCCAGAAACGTCCTGTGTCA
    AGTGATGAAATCAACATGGTAGTCAATCGTATCGAACAGAAACTCCGTGGTCGAAATGAA
    AATGAAATTCAAAGTGAGGACATTGGTTCACTCGTCATGGAGGAGTTGGCTGAATTGGAC
    GAGATTACCTATGTACGTTTTGCTAGTGTCTATCGTAGTTTTAAGGATGTCAGTGAGTTA
    GAGAGCTTGCTCCAACAAATCACCCAGTCCTCTAAAAAGAAAAAGGAAAGATAA
    60
    120
    180
    240
    300
    360
    420
    480
    534

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1557 [new locus tag: SPR_RS07725 ]
  • symbol: spr1557
  • description: Conserved hypothetical protein
  • length: 177
  • theoretical pI: 9.69227
  • theoretical MW: 21090.8
  • GRAVY: -1.01017

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions transcriptional regulator NrdR (TIGR00244; HMM-score: 189.7)
    and 7 more
    Signal transduction Regulatory functions DNA interactions putative regulatory protein, FmdB family (TIGR02605; HMM-score: 16.1)
    Genetic information processing Mobile and extrachromosomal element functions Prophage functions restriction alleviation protein, Lar family (TIGR03655; HMM-score: 16.1)
    Genetic information processing DNA metabolism Restriction/modification restriction alleviation protein, Lar family (TIGR03655; HMM-score: 16.1)
    Cys-rich peptide, TIGR04165 family (TIGR04165; HMM-score: 13.9)
    Genetic information processing Transcription Transcription factors transcription factor S (TIGR01384; HMM-score: 13.6)
    cxxc_20_cxxc protein (TIGR04104; HMM-score: 11)
    MJ0042 family finger-like domain (TIGR02098; HMM-score: 8.5)
  • TheSEED  :
    • Ribonucleotide reductase transcriptional regulator NrdR
    Nucleosides and Nucleotides Nucleosides and Nucleotides - no subcategory Ribonucleotide reduction  Ribonucleotide reductase transcriptional regulator NrdR
  • PFAM:
    no clan defined ATP-cone; ATP cone domain (PF03477; HMM-score: 73.2)
    and 13 more
    Zn_Beta_Ribbon (CL0167) Zn_Tnp_IS1595; Transposase zinc-ribbon domain (PF12760; HMM-score: 20.7)
    TFIIS_C; Transcription factor S-II (TFIIS) (PF01096; HMM-score: 20.6)
    Ribosomal_S27; Ribosomal protein S27a (PF01599; HMM-score: 16)
    Zn-ribbon_8; Zinc ribbon domain (PF09723; HMM-score: 15.4)
    no clan defined DnaJ_CXXCXGXG; DnaJ central domain (PF00684; HMM-score: 14.8)
    DiS_P_DiS; Bacterial Peptidase A24 N-terminal domain (PF06750; HMM-score: 14)
    POTRA (CL0191) POTRA_2; POTRA domain, ShlB-type (PF08479; HMM-score: 13.4)
    Zn_Beta_Ribbon (CL0167) zf-ribbon_3; zinc-ribbon domain (PF13248; HMM-score: 12.7)
    Beta-tent (CL0080) GFA; Glutathione-dependent formaldehyde-activating enzyme (PF04828; HMM-score: 12.5)
    no clan defined FdhE; Protein involved in formate dehydrogenase formation (PF04216; HMM-score: 11.6)
    HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA (PF01155; HMM-score: 11.1)
    Zn_Beta_Ribbon (CL0167) zinc_ribbon_4; zinc-ribbon domain (PF13717; HMM-score: 10)
    Nudix_N_2; Nudix N-terminal (PF14803; HMM-score: 9)

⊟Structure, modifications & cofactors[edit | edit source]

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.018785
    • TAT(Tat/SPI): 0.00453
    • LIPO(Sec/SPII): 0.010029
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MFWESLKKWYNEKKTIRRERMRCPKCGATKSSVIDSRQAEEGNTIRRRRECDECQHRFTTYERVEERTLVVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSDEINMVVNRIEQKLRGRNENEIQSEDIGSLVMEELAELDEITYVRFASVYRSFKDVSELESLLQQITQSSKKKKER

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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