From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1064 [new locus tag: SPR_RS05315 ]
  • pan locus tag?: PNEUPAN002444000
  • symbol: nrdH
  • pan gene symbol?: nrdH
  • synonym:
  • product: Glutaredoxin-like protein involved in electron transport system for ribonucleotide reductase system NrdEF

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1064 [new locus tag: SPR_RS05315 ]
  • symbol: nrdH
  • product: Glutaredoxin-like protein involved in electron transport system for ribonucleotide reductase system NrdEF
  • replicon: chromosome
  • strand: +
  • coordinates: 1061970..1062206
  • length: 237
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    TTGAAGAGGAGTTACACAATGGTAACCGTTTATTCTAAAAACAATTGTGTCCAATGTAAA
    ATGACCAAGCGTTTCTTGGACAGTAATAATGTCTCTTATCGTGAAATCAATCTTGATGAG
    CAACCTGAGTACGTCGATCAAGTTAAAGAGCTCGGTTTTAGCGCAGCTCCTGTTATCCAA
    ACACCAACTGAAGTCTTTTCAGGTTTCCAACCAGGAAAACTGAAACAATTAGCATAA
    60
    120
    180
    237

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1064 [new locus tag: SPR_RS05315 ]
  • symbol: NrdH
  • description: Glutaredoxin-like protein involved in electron transport system for ribonucleotide reductase system NrdEF
  • length: 78
  • theoretical pI: 8.70362
  • theoretical MW: 8941.19
  • GRAVY: -0.50641

⊟Function[edit | edit source]

  • TIGRFAM:
    glutaredoxin-like protein NrdH (TIGR02194; HMM-score: 115.6)
    and 7 more
    glutaredoxin-like protein, YruB-family (TIGR02196; HMM-score: 58.1)
    Metabolism Energy metabolism Electron transport glutaredoxin 3 (TIGR02181; HMM-score: 31.9)
    Signal transduction Regulatory functions DNA interactions transcriptional regulator, Spx/MgsR family (TIGR01617; HMM-score: 30.8)
    glutaredoxin-like protein (TIGR02200; HMM-score: 29)
    glutaredoxin (TIGR02180; HMM-score: 21)
    glutaredoxin-family domain (TIGR02190; HMM-score: 20.3)
    glutaredoxin-like family (TIGR02189; HMM-score: 13.2)
  • TheSEED  :
    • Glutaredoxin-like protein NrdH, associated with reduction of ribonucleotide reductase class Ib
    Nucleosides and Nucleotides Nucleosides and Nucleotides - no subcategory Ribonucleotide reduction  Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib
    and 2 more
    Stress Response Oxidative stress Glutaredoxins  Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib
    Stress Response Oxidative stress Glutathione: Redox cycle  Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib
  • PFAM:
    Thioredoxin (CL0172) Glutaredoxin; Glutaredoxin (PF00462; HMM-score: 54.6)
    and 1 more
    Thioredoxin_2; Thioredoxin-like domain (PF13098; HMM-score: 13.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.019757
    • TAT(Tat/SPI): 0.000379
    • LIPO(Sec/SPII): 0.008129
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKRSYTMVTVYSKNNCVQCKMTKRFLDSNNVSYREINLDEQPEYVDQVKELGFSAAPVIQTPTEVFSGFQPGKLKQLA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: NrdR* (repression) regulon
    NrdR*(TF)important in Deoxyribonucleotide biosynthesis; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=spr1064&oldid=129723"