⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 26-OCT-2021

⊟Summary

• organism: Streptococcus pneumoniae R6
locus tag: SPR_RS02705 [old locus tag: spr0534 ]
pan locus tag^?: PNEUPAN001537000
symbol: SPR_RS02705
pan gene symbol^?: glnH2
• synonym:
• product: transporter substrate-binding domain-containing protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPR_RS02705 [old locus tag: spr0534 ]
• symbol: SPR_RS02705
• product: transporter substrate-binding domain-containing protein
• replicon: chromosome
• strand: -
• coordinates: 533461..534255
• length: 795
• essential: unknown

⊟Accession numbers

• Location: NC_003098 (533461..534255) NCBI
• BioCyc: see spr0534
• MicrobesOnline: see spr0534
• PneumoBrowse for strain D39V: SPV_0530 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  601
  661
  721
  781
  
  ATGAAAAAAAAATTCTTTTTATCAGCATTATTGATTAGCCTTTTCGGCCTTGCTGCTGCC
  AAACCAGTCCAGGCTGATACTAGTATCGCAGACATTCAAAAAAGAGGCGAACTGGTTGTC
  GGTGTCAAACAAGACGTTCCCAATTTTGGTTACAAAGATCCCAAGACCGGTACTTATTCT
  GGTATCGAAACCGACTTGGCCAAGATGGTAGCTGATGAACTCAAGGTCAAGATTCGCTAT
  GTGCCGGTTACAGCACAAACCCGCGGCCCCCTTCTAGACAATGAACAGGTCGATATGGAT
  ATCGCGACCTTTACCATCACGGACGAACGCAAAAAACTCTACAACTTTACCAGTCCCTAC
  TACACAGACGCTTCTGGATTTTTGGTCAATAAATCTGCCAAAATCAAAAAGATTGAGGAC
  CTAAACGGCAAAACCATCGGAGTCGCCCAAGGTTCTATCACCCAACGCCTGATTACTGAA
  CTGGGTAAAAAGAAAGGTCTGAAGTTTAAATTCGTCGAACTTGGTTCCTACCCAGAATTG
  ATTACTTCCCTGCACGCTCATCGTATCGATACCTTTTCCGTTGACCGCTCTATTCTATCT
  GGCTACACTAGTAAACGGACAGCACTACTAGATGATAGTTTCAAGCCATCTGACTACGGT
  ATTGTTACCAAGAAATCAAATACAGAGCTCAACGACTATCTTGATAACTTGGTTACTAAA
  TGGAGCAAGGATGGTAGTTTGCAGAAACTTTATGACCGTTACAAGCTCAAACCATCTAGC
  CATACTGCAGATTAA
  60
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  540
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  795
  

⊟Protein

⊟General

• locus tag: SPR_RS02705 [old locus tag: spr0534 ]
• symbol: SPR_RS02705
• description: transporter substrate-binding domain-containing protein
• length: 264
• theoretical pI: 9.88602
• theoretical MW: 29453.6
• GRAVY: -0.385985

⊟Function

• ⊞⊞TIGRFAM:
  Metabolism Transport and binding proteins Amino acids, peptides and amines lysine-arginine-ornithine-binding periplasmic protein (TIGR01096; HMM-score: 146.1)
  and 9 more
  Metabolism Transport and binding proteins Amino acids, peptides and amines ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB (TIGR02995; HMM-score: 42.2)
  extracellular substrate-binding orphan protein, GRRM family (TIGR04262; HMM-score: 31.7)
  Metabolism Transport and binding proteins Other ABC transporter, substrate-binding protein, aliphatic sulfonates family (TIGR01728; HMM-score: 26.7)
  Metabolism Transport and binding proteins Unknown substrate TRAP transporter solute receptor, TAXI family (TIGR02122; HMM-score: 24.6)
  Metabolism Transport and binding proteins Anions phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein (TIGR01098; HMM-score: 20.8)
  quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein (TIGR03871; HMM-score: 20.1)
  Metabolism Energy metabolism Other methanol oxidation system protein MoxJ (TIGR03870; HMM-score: 17.2)
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids methanol oxidation system protein MoxJ (TIGR03870; HMM-score: 17.2)
  taurine ABC transporter, periplasmic binding protein (TIGR01729; HMM-score: 12.1)
• TheSEED: see spr0534
• ⊞⊞PFAM:
  PBP (CL0177) SBP_bac_3; Bacterial extracellular solute-binding proteins, family 3 (PF00497; HMM-score: 166.4)
  and 5 more
  NMT1; NMT1/THI5 like (PF09084; HMM-score: 37.2)
  Lig_chan-Glu_bd; Ligated ion channel L-glutamate- and glycine-binding site (PF10613; HMM-score: 27.4)
  Phosphonate-bd; ABC transporter, phosphonate, periplasmic substrate-binding protein (PF12974; HMM-score: 23.7)
  YhfZ_C; YhfZ C-terminal domain (PF14503; HMM-score: 23.5)
  NMT1_3; NMT1-like family (PF16868; HMM-score: 15.5)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• ⊞⊞SignalP: Signal peptide SP(Sec/SPI) length 25 aa
  • SP(Sec/SPI): 0.994929
  • TAT(Tat/SPI): 0.000863
  • LIPO(Sec/SPII): 0.003787
  • Cleavage Site: CS pos: 25-26. VQA-DT. Pr: 0.9653
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000726170 NCBI
• UniProt: see spr0534

⊟Protein sequence

• MKKKFFLSALLISLFGLAAAKPVQADTSIADIQKRGELVVGVKQDVPNFGYKDPKTGTYSGIETDLAKMVADELKVKIRYVPVTAQTRGPLLDNEQVDMDIATFTITDERKKLYNFTSPYYTDASGFLVNKSAKIKKIEDLNGKTIGVAQGSITQRLITELGKKKGLKFKFVELGSYPELITSLHAHRIDTFSVDRSILSGYTSKRTALLDDSFKPSDYGIVTKKSNTELNDYLDNLVTKWSKDGSLQKLYDRYKLKPSSHTAD

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: SPR_RS02695 < SPR_RS02700 < SPR_RS02705 < SPR_RS02710

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_0530 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications