⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 30-JAN-2014

⊟Summary

• organism: Streptococcus pneumoniae R6
locus tag: spr0739 [new locus tag: SPR_RS03705 ]
pan locus tag^?: PNEUPAN001785000
symbol: flaR
pan gene symbol^?: flaR
• synonym:
• product: Modulates DNA topology

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: spr0739 [new locus tag: SPR_RS03705 ]
• symbol: flaR
• product: Modulates DNA topology
• replicon: chromosome
• strand: -
• coordinates: 737238..737762
• length: 525
• essential: unknown

⊟Accession numbers

• Location: AE007317 (737238..737762) NCBI
• BioCyc: SPR0739 BioCyc
• MicrobesOnline: 133624 MicrobesOnline
• PneumoBrowse for strain D39V: SPV_0731 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  
  ATGAAAATCACAATTATCGGATATTCTGGTTCTGGTAAGTCAACTCTAGCAGAAAAGTTA
  TCTAACTACTACTCCATTCCAAAACTGCACATGGACACACTCCAATTTCAACCTGGTTGG
  CAAGACAGTGACTGCGAATGGATGTTAACCGAGATAAAAAACTTTCTCACCAAGCATAAA
  GCTTGGGTCATCGATGGTAATTATTCTTGGTGCTACTACCAAGAACGAATGCAAGAAGCT
  GACCAAATCATCTTTCTCAATTTTTTGCCATTGACCTGTCTCTTTAGAGCCTTTAAGCGT
  TATCTTAAATACCGTGGAAAAGTCAGAGAAAGTATGGCGGCAGATTGCCCTGAACGCTTT
  GAGTGGGAGTTTATCAGATGGATTCTTTGGGATGGGCGTAGCAAAACTCAAAAAGAAAAT
  TACCAAAAACTTTGCCAAGAATATTCACATAAAGTCACTATCCTTCGAAATCAGAGAGAG
  CTAGATCAATTTCTGGATAAGAAAAGGAAGTCCTACAATTCATAA
  60
  120
  180
  240
  300
  360
  420
  480
  525
  

⊟Protein

⊟General

• locus tag: spr0739 [new locus tag: SPR_RS03705 ]
• symbol: FlaR
• description: Modulates DNA topology
• length: 174
• theoretical pI: 9.26926
• theoretical MW: 21135.1
• GRAVY: -0.724138

⊟Function

• ⊞⊞TIGRFAM:
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A dephospho-CoA kinase (TIGR00152; EC 2.7.1.24; HMM-score: 18.9)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine kinase (TIGR00235; EC 2.7.1.48; HMM-score: 18.2)
  Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 17.8)
  putative cytidylate kinase (TIGR02173; EC 2.7.4.14; HMM-score: 16.5)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking ABC-type bacteriocin transporter (TIGR01193; HMM-score: 15.6)
  Genetic information processing Protein fate Protein modification and repair ABC-type bacteriocin transporter (TIGR01193; HMM-score: 15.6)
  Metabolism Transport and binding proteins Other ABC-type bacteriocin transporter (TIGR01193; HMM-score: 15.6)
  and 21 more
  Cellular processes Cellular processes Pathogenesis type I secretion system ATPase (TIGR03375; HMM-score: 13.6)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR03375; HMM-score: 13.6)
  Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 13.1)
  Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 13.1)
  Metabolism Energy metabolism Amino acids and amines ethanolamine utilization protein, EutP (TIGR02528; HMM-score: 13)
  carbohydrate kinase, thermoresistant glucokinase family (TIGR01313; EC 2.7.1.-; HMM-score: 12.9)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions adenylate kinase (TIGR01351; EC 2.7.4.-; HMM-score: 12.9)
  Metabolism Transport and binding proteins Anions phosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 12.1)
  thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 11.8)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions cytidylate kinase (TIGR00017; EC 2.7.4.14; HMM-score: 11.7)
  Metabolism Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 11.6)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 11.5)
  Unknown function General GTP-binding protein HflX (TIGR03156; HMM-score: 11.5)
  Cellular processes Cellular processes Toxin production and resistance putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 11.4)
  Metabolism Transport and binding proteins Unknown substrate putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 11.4)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 11.3)
  Metabolism Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 11.3)
  Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 10.2)
  Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 10.2)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 9.9)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01842; HMM-score: 9.8)
• TheSEED  :
  • DNA topology modulation protein flar-related protein
• ⊞⊞PFAM:
  P-loop_NTPase (CL0023) AAA_18; AAA domain (PF13238; HMM-score: 24)
  and 21 more
  AAA_22; AAA domain (PF13401; HMM-score: 17.8)
  ABC_tran; ABC transporter (PF00005; HMM-score: 17.7)
  AAA_33; AAA domain (PF13671; HMM-score: 16.8)
  dNK; Deoxynucleoside kinase (PF01712; HMM-score: 16.6)
  AAA_16; AAA ATPase domain (PF13191; HMM-score: 16.2)
  PRK; Phosphoribulokinase / Uridine kinase family (PF00485; HMM-score: 16.1)
  AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 15.4)
  AAA_17; AAA domain (PF13207; HMM-score: 15.4)
  MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 15)
  ATP_bind_1; Conserved hypothetical ATP binding protein (PF03029; HMM-score: 14.9)
  AAA_24; AAA domain (PF13479; HMM-score: 14.4)
  AAA_28; AAA domain (PF13521; HMM-score: 14.2)
  AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 13.8)
  MobB; Molybdopterin guanine dinucleotide synthesis protein B (PF03205; HMM-score: 13)
  NACHT; NACHT domain (PF05729; HMM-score: 13)
  PduV-EutP; Ethanolamine utilisation - propanediol utilisation (PF10662; HMM-score: 12.9)
  AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 12.7)
  APS_kinase; Adenylylsulphate kinase (PF01583; HMM-score: 12.6)
  SRP54; SRP54-type protein, GTPase domain (PF00448; HMM-score: 12.2)
  RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 12.2)
  AAA_23; AAA domain (PF13476; HMM-score: 11.5)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.034514
  • TAT(Tat/SPI): 0.000376
  • LIPO(Sec/SPII): 0.008253
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: AAK99543 NCBI
• UniProt: Q8DQC8 UniProt

⊟Protein sequence

• MKITIIGYSGSGKSTLAEKLSNYYSIPKLHMDTLQFQPGWQDSDCEWMLTEIKNFLTKHKAWVIDGNYSWCYYQERMQEADQIIFLNFLPLTCLFRAFKRYLKYRGKVRESMAADCPERFEWEFIRWILWDGRSKTQKENYQKLCQEYSHKVTILRNQRELDQFLDKKRKSYNS

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: flaR < rpsT < coaA

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0731 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications