⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 06-FEB-2015

⊟Summary

• organism: Streptococcus pneumoniae ATCC 700669
locus tag: SPN23F12080 [new locus tag: SPN23F_RS06135 ]
pan locus tag^?: PNEUPAN000236000
symbol: ntpB
pan gene symbol^?: ntpB
• synonym:
• product: V-type sodium ATP synthase subunit B

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPN23F12080 [new locus tag: SPN23F_RS06135 ]
• symbol: ntpB
• product: V-type sodium ATP synthase subunit B
• replicon: chromosome
• strand: -
• coordinates: 1174805..1176190
• length: 1386
• essential: unknown

⊟Accession numbers

• Location: FM211187 (1174805..1176190) NCBI
• BioCyc: see SPN23F_RS06135
• MicrobesOnline: 5831053 MicrobesOnline
• PneumoBrowse for strain D39V:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  1321
  1381
  
  ATGAGTGTTATAAAAGAATACAGAACTGCTAGTGAAGTTGTTGGGCCTCTTATGATTGTT
  GAACAAGTAAATAATGTGTCTTACAATGAGTTAGTTGAAATTCAACTTCATAATGGAGAA
  ATTCGTCGTGGACAAGTTTTAGAGATCCACGAAGATAAAGCAATGGTTCAGCTTTTTGAA
  GGATCTAGTGGAATAAATTTAGAAAAGTCTAAAATTCGTTTTGCTGGTCATGCATTAGAA
  TTGGCTGTATCTGAGGATATGGTTGGTCGTATTTTTAATGGGATGGGAAAACCAATTGAT
  GGTGGACCAGATTTAATTCCAGAGAAATATTTAGATATTGATGGTCAAGCTATTAATCCT
  GTATCTAGAGATTATCCAGATGAATTTATTCAGACAGGGATCTCCTCTATTGATCATTTG
  AATACTCTTGTACGTGGTCAAAAATTACCAGTATTTTCAGGTTCGGGCTTACCTCATAAT
  GAATTAGCTGCTCAGATAGCAAGACAAGCGACTGTTTTAAATTCTGATGAAAATTTTGCG
  GTTGTATTTGCAGCAATGGGTATTACTTTTGAAGAAGCTGAGTTTTTTATGGAAGAACTC
  AGAAAAACAGGAGCGATCGATCGTTCGGTTTTATTTATGAACTTGGCAAATGATCCTGCA
  ATTGAGCGTATTGCAACTCCCCGCATTGCTTTAACTGCGGCAGAGTATCTAGCTTTTGAA
  AAAGATATGCACGTTCTAGTTATCATGACGGATATGACTAACTATTGTGAAGCGTTACGT
  GAAGTCTCGGCAGCTCGCCGTGAAGTTCCAGGGAGACGAGGCTATCCGGGATATTTATAT
  ACAAATTTATCAACTCTATACGAAAGGGCTGGTCGCTTAGTTGGTAAAAAAGGTTCGGTG
  ACACAGATTCCTATTTTAACAATGCCAGAAGATGACATAACACATCCAATTCCTGATTTA
  ACTGGATACATTACTGAAGGGCAAATTATTTTGTCGCATGAGTTGTATAATCAAGGTTAT
  CGTCCACCAATCAATGTTTTACCTTCTCTCTCTCGATTAAAAGATAAGGGATCTGGAGAA
  GGTAAAACTCGTGGAGATCATGCTCCAACTATGAATCAACTGTTTGCAGCCTATGCCCAA
  GGGAAAAAGGTTGAAGAGTTAGCAGTAGTATTAGGAGAATCGGCTTTATCTGATGTAGAT
  AAATTGTATGTGAGGTTTACAAAGCGTTTTGAAGAAGAGTACATAAACCAAGGATTTTAT
  AAAAATCGAAATATAGAAGATACGTTGAATCTTGGGTGGGAATTACTATCAATTCTTCCT
  AGAACAGAGTTAAAACGTATCAAAGATGATTTGCTTGATAAATACTTACCTTTGGTAGAA
  GTTTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  1260
  1320
  1380
  1386
  

⊟Protein

⊟General

• locus tag: SPN23F12080 [new locus tag: SPN23F_RS06135 ]
• symbol: NtpB
• description: V-type sodium ATP synthase subunit B
• length: 461
• theoretical pI: 4.83468
• theoretical MW: 51594.5
• GRAVY: -0.227766

⊟Function

• ⊞⊞reaction:
  EC 3.6.3.15?  ExPASy
  Sodium-transporting two-sector ATPase ATP + H₂O + Na⁺(In) = ADP + phosphate + Na⁺(Out)
• ⊞⊞TIGRFAM:
  Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase archaeal, B subunit (TIGR01041; EC 3.6.3.14; HMM-score: 769.5)
  Metabolism Transport and binding proteins Cations and iron carrying compounds V-type ATPase, B subunit (TIGR01040; EC 3.6.3.14; HMM-score: 682.9)
  and 12 more
  Cellular processes Cellular processes Chemotaxis and motility flagellar protein export ATPase FliI (TIGR03496; EC 3.6.3.14; HMM-score: 200.3)
  flagellar protein export ATPase FliI (TIGR03498; EC 3.6.3.14; HMM-score: 198.9)
  Metabolism Energy metabolism ATP-proton motive force interconversion ATPase, FliI/YscN family (TIGR01026; EC 3.6.3.14; HMM-score: 193.8)
  Cellular processes Cellular processes Pathogenesis type III secretion apparatus H+-transporting two-sector ATPase (TIGR02546; EC 3.6.3.14; HMM-score: 192.8)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type III secretion apparatus H+-transporting two-sector ATPase (TIGR02546; EC 3.6.3.14; HMM-score: 192.8)
  Cellular processes Cellular processes Chemotaxis and motility flagellar protein export ATPase FliI (TIGR03497; EC 3.6.3.14; HMM-score: 183.1)
  Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase F1, alpha subunit (TIGR00962; EC 3.6.3.14; HMM-score: 153.2)
  alternate F1F0 ATPase, F1 subunit alpha (TIGR03324; EC 3.6.3.-; HMM-score: 135.5)
  Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase F1, beta subunit (TIGR01039; EC 3.6.3.14; HMM-score: 127.7)
  alternate F1F0 ATPase, F1 subunit beta (TIGR03305; EC 3.6.3.-; HMM-score: 118.8)
  Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase archaeal, A subunit (TIGR01043; EC 3.6.3.14; HMM-score: 113.5)
  Metabolism Transport and binding proteins Cations and iron carrying compounds V-type ATPase, A subunit (TIGR01042; EC 3.6.3.14; HMM-score: 97.7)
• TheSEED  :
  • V-type ATP synthase subunit B (EC 3.6.3.14)
  Respiration ATP synthases V-Type ATP synthase  V-type ATP synthase subunit B (EC 3.6.3.14)
• ⊞⊞PFAM:
  P-loop_NTPase (CL0023) ATP-synt_ab; ATP synthase alpha/beta family, nucleotide-binding domain (PF00006; HMM-score: 222)
  and 2 more
  HAS-barrel (CL0275) ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain (PF02874; HMM-score: 44.1)
  HAS-barrel; HAS barrel domain (PF09378; HMM-score: 16.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.002776
  • TAT(Tat/SPI): 0.00008
  • LIPO(Sec/SPII): 0.000214
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: CAR69011 NCBI
• UniProt: B8ZK30 UniProt

⊟Protein sequence

• MSVIKEYRTASEVVGPLMIVEQVNNVSYNELVEIQLHNGEIRRGQVLEIHEDKAMVQLFEGSSGINLEKSKIRFAGHALELAVSEDMVGRIFNGMGKPIDGGPDLIPEKYLDIDGQAINPVSRDYPDEFIQTGISSIDHLNTLVRGQKLPVFSGSGLPHNELAAQIARQATVLNSDENFAVVFAAMGITFEEAEFFMEELRKTGAIDRSVLFMNLANDPAIERIATPRIALTAAEYLAFEKDMHVLVIMTDMTNYCEALREVSAARREVPGRRGYPGYLYTNLSTLYERAGRLVGKKGSVTQIPILTMPEDDITHPIPDLTGYITEGQIILSHELYNQGYRPPINVLPSLSRLKDKGSGEGKTRGDHAPTMNQLFAAYAQGKKVEELAVVLGESALSDVDKLYVRFTKRFEEEYINQGFYKNRNIEDTLNLGWELLSILPRTELKRIKDDLLDKYLPLVEV

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: ntpD < ntpB < ntpA < SPN23F12100 < ntpC < ntpE < ntpK < ntpI < SPN23F12150 < SPN23F12160 < SPN23F12170 < SPN23F12180 < SPN23F12190 < SPN23F12200 < nanA < nanE

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V:

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications