⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 02-FEB-2021

⊟Summary

• organism: Streptococcus pneumoniae D39
locus tag: SPD_RS02485 [old locus tag: SPD_0461 ]
pan locus tag^?: PNEUPAN001408000
symbol: dnaJ
pan gene symbol^?: dnaJ
• synonym:
• product: molecular chaperone DnaJ

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPD_RS02485 [old locus tag: SPD_0461 ]
• symbol: dnaJ
• product: molecular chaperone DnaJ
• replicon: chromosome
• strand: +
• coordinates: 472172..473290
• length: 1119
• essential: unknown

⊟Accession numbers

• Location: NC_008533 (472172..473290) NCBI
• BioCyc: G1G6V-512 BioCyc
• MicrobesOnline: see SPD_0461
• PneumoBrowse for strain D39V: SPV_0461 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  
  ATGAACAATACTGAATTTTATGATCGTCTGGGGGTATCCAAAAACGCTTCGGCAGACGAA
  ATCAAAAAGGCTTATCGTAAGCTTTCCAAAAAATATCACCCAGATATCAACAAGGAGCCT
  GGTGCTGAGGACAAGTACAAGGAAGTTCAAGAAGCCTATGAGACTTTGAGTGACGACCAA
  AAACGTGCTGCCTATGACCAGTATGGTGCTGCAGGCGCCAATGGTGGTTTCGGTGGTTTC
  AATGGGGCAGGTGGCTTCGGTGGTTTTGAGGATATTTTCTCAAGTTTCTTCGGCGGAGGC
  GGTTCTTCGCGCAATCCAAACGCTCCTCGCCAAGGAGATGATCTCCAGTATCGTGTCAAT
  TTGACCTTTGAAGAAGCTATCTTCGGAACTGAGAAGGAAGTTAAGTATCATCGTGAAGCT
  GGCTGTCGTACATGTAATGGCTCTGGTGCTAAGCCAGGGACAAGTCCAGTCACTTGTGGA
  CGCTGTCATGGCGCTGGTGTCATTAACGTCGATACGCAGACTCCTCTTGGTATGATGCGT
  CGCCAAGTAACCTGTGATGTCTGTCACGGTCGAGGAAAAGAAATCAAATATCCATGTACA
  ACCTGTCATGGAACAGGTCATGAGAAACAAGCTCATAGCGTACATGTGAAAATCCCTGCT
  GGTGTGGAAACAGGTCAACAAATTCGCCTCGCTGGTCAAGGTGAAGCAGGCTTTAACGGT
  GGACCTTATGGTGACTTGTATGTAGTAGTTTCTGTGGAAGCTAGCGACAAGTTTGAACGT
  GAAGGAACGACTATCTTCTACAATCTCAACCTCAACTTTGTCCAAGCGGCTCTTGGTGAT
  ACAGTAGATATTCCAACTGTTCACGGTGATGTTGAATTGGTTATTCCAGAGGGAACTCAG
  ACTGGTAAGAAATTCCGCCTACGTAGTAAGGGGGCACCGAGCCTTCGTGGCGGTGCAGTT
  GGTGACCAATACGTTACTGTTAATGTCGTAACACCGACAGGCTTGAACGACCGCCAAAAA
  GTAGCCTTGAAAGAATTCGCGGCTGCTGGTGACTTGAAAGTAAATCCAAAGAAAAAAGGC
  TTCTTTGACCATATTAAAGATGCCTTTGATGGAGAATAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1119
  

⊟Protein

⊟General

• locus tag: SPD_RS02485 [old locus tag: SPD_0461 ]
• symbol: DnaJ
• description: molecular chaperone DnaJ
• length: 372
• theoretical pI: 7.25998
• theoretical MW: 40055.3
• GRAVY: -0.602688

⊟Function

• ⊞⊞TIGRFAM:
  chaperone protein DnaJ (TIGR02349; HMM-score: 453.2)
  and 4 more
  Cellular processes Cellular processes Chemotaxis and motility terminal organelle assembly protein TopJ (TIGR03835; HMM-score: 94.8)
  Genetic information processing Protein fate Protein folding and stabilization Fe-S protein assembly co-chaperone HscB (TIGR00714; HMM-score: 23.1)
  c(7)-type cytochrome triheme domain (TIGR04257; HMM-score: 7)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit A (TIGR00630; EC 3.1.25.-; HMM-score: 5.6)
• TheSEED: see SPD_0461
• ⊞⊞PFAM:
  no clan defined DnaJ_C; DnaJ C terminal domain (PF01556; HMM-score: 138.8)
  and 9 more
  Chaperone-J (CL0392) DnaJ; DnaJ domain (PF00226; HMM-score: 89.7)
  no clan defined DnaJ_CXXCXGXG; DnaJ central domain (PF00684; HMM-score: 58.4)
  Anti-TRAP; Tryptophan RNA-binding attenuator protein inhibitory protein (PF15777; HMM-score: 18.3)
  Multiheme_cytos (CL0317) Cytochrome_C7; Cytochrome c7 and related cytochrome c (PF14522; HMM-score: 17.3)
  no clan defined RseC_MucC; Positive regulator of sigma(E), RseC/MucC (PF04246; HMM-score: 12.7)
  DUF5351; Family of unknown function (DUF5351) (PF17302; HMM-score: 10.4)
  Multiheme_cytos (CL0317) Cytochrom_c3_2; Cytochrome c3 (PF14537; HMM-score: 9.8)
  RING (CL0229) zf-RING_15; KIAA1045 RING finger (PF16744; HMM-score: 9.7)
  no clan defined TackOD1; Thaumarchaeal output domain 1 (PF18551; HMM-score: 7.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.023781
  • TAT(Tat/SPI): 0.002549
  • LIPO(Sec/SPII): 0.004279
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_001066302 NCBI
• UniProt: see SPD_0461

⊟Protein sequence

• MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAEDKYKEVQEAYETLSDDQKRAAYDQYGAAGANGGFGGFNGAGGFGGFEDIFSSFFGGGGSSRNPNAPRQGDDLQYRVNLTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGTSPVTCGRCHGAGVINVDTQTPLGMMRRQVTCDVCHGRGKEIKYPCTTCHGTGHEKQAHSVHVKIPAGVETGQQIRLAGQGEAGFNGGPYGDLYVVVSVEASDKFEREGTTIFYNLNLNFVQAALGDTVDIPTVHGDVELVIPEGTQTGKKFRLRSKGAPSLRGGAVGDQYVTVNVVTPTGLNDRQKVALKEFAAAGDLKVNPKKKGFFDHIKDAFDGE

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: hrcA > grpE > dnaK > SPD_RS02480 > dnaJ

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0461 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications