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serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1994 [new locus tag: SPR_RS10160 ]
  • pan locus tag?: PNEUPAN003885000
  • symbol: spr1994
  • pan gene symbol?: dusB
  • synonym:
  • product: Conserved hypothetical protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1994 [new locus tag: SPR_RS10160 ]
  • symbol: spr1994
  • product: Conserved hypothetical protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1986304..1987314
  • length: 1011
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    TTGATGAAAAGGACCTGGAGGAACTCATTCGTGACAAATCTTAATACACCTTTTATGATT
    GGCAATATTGAGATTCCCAATCGTACCGTTTTAGCGCCTATGGCTGGCGTGACCAACTCA
    GCCTTTCGTACCATCGCAAAAGAGCTCGGAGCTGGACTCGTTGTAATGGAAATGGTCTCT
    GACAAGGGAATCCAATACAACAACGAAAAAACCCTGCATATGCTTCATATCGATGAGGGC
    GAAAACCCTGTCTCTATCCAACTTTTTGGTAGCGATGAAGACAGCCTAGCACGCGCAGCA
    GAATTCATCCAAGAAAACACCAAGACCGATATCGTCGATATCAACATGGGCTGCCCTGTC
    AACAAAATCGTGAAGAACGAAGCTGGAGCTATGTGGCTCAAGGATCCTGACAAGATCTAC
    TCTATCATCAACAAGGTCCAGTCTGTCCTTGATATCCCACTTACTGTCAAAATGCGTACC
    GGCTGGGCGGACCCATCTCTGGCAGTAGAAAATGCCCTCGCTGCTGAGGCTGCAGGTGTT
    TCTGCCCTCGCCATGCATGGCCGTACCCGTGAACAAATGTATACTGGCCACGCAGACCTT
    GAGACCCTTTACAAGGTTGCCCAAGCTCTAACCAAGATTCCATTCATCGCCAACGGTGAT
    ATCCGTACTGTCCAAGAAGCCAAGCAACGCATCGAAGAAGTTGGTGCTGACGCAGTCATG
    ATTGGCCGAGCTGCCATGGGAAATCCTTACCTCTTCAACCAAATCAACCATTACTTTGAA
    ACAGGAGAAATCCTACCTGATTTGACCTTTGAAGACAAGATGAAGATCGCCTACGAACAC
    TTGAAACGATTGATTAACCTCAAAGGAGAAAACGTCGCAGTTCGTGAATTCCGCGGCCTC
    GCTCCTCACTATCTCCGTGGAACATCTGGCGCTGCCAAACTCCGTGGAGCCATTTCGCAA
    GCTAGCACCCTAGCAGAGATTGAAGCCCTCTTGCAATTGGAGAAGGCTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1011

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1994 [new locus tag: SPR_RS10160 ]
  • symbol: spr1994
  • description: Conserved hypothetical protein
  • length: 336
  • theoretical pI: 6.1846
  • theoretical MW: 37087.5
  • GRAVY: -0.140476

⊟Function[edit | edit source]

  • TIGRFAM:
    Unknown function General putative TIM-barrel protein, nifR3 family (TIGR00737; HMM-score: 360.8)
    and 10 more
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA dihydrouridine synthase A (TIGR00742; EC 1.-.-.-; HMM-score: 104.9)
    dihydroorotate dehydrogenase family protein (TIGR01037; EC 1.3.-.-; HMM-score: 52.2)
    Unknown function General putative TIM-barrel protein (TIGR00736; HMM-score: 36)
    Metabolism Amino acid biosynthesis Histidine family imidazoleglycerol phosphate synthase, cyclase subunit (TIGR00735; HMM-score: 23.4)
    glycosyl amidation-associated protein WbuZ (TIGR03572; HMM-score: 22.9)
    Metabolism Energy metabolism Other L-lactate oxidase (TIGR02708; EC 1.1.3.-; HMM-score: 18.7)
    mycofactocin system FadH/OYE family oxidoreductase 2 (TIGR03997; EC 1.-.-.-; HMM-score: 16.9)
    Metabolism Amino acid biosynthesis Histidine family 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (TIGR00007; EC 5.3.1.16; HMM-score: 16.6)
    heme/flavin dehydrogenase, mycofactocin system (TIGR03966; EC 1.-.-.-; HMM-score: 14.8)
    geranylgeranylglyceryl phosphate synthase family protein (TIGR01768; EC 2.5.1.-; HMM-score: 13)
  • TheSEED  :
    • tRNA-dihydrouridine synthase DusB
    RNA Metabolism RNA processing and modification tRNA modification Archaea  tRNA dihydrouridine synthase B (EC 1.-.-.-)
  • PFAM:
    TIM_barrel (CL0036) Dus; Dihydrouridine synthase (Dus) (PF01207; HMM-score: 303.5)
    and 5 more
    Oxidored_FMN; NADH:flavin oxidoreductase / NADH oxidase family (PF00724; HMM-score: 25)
    FMN_dh; FMN-dependent dehydrogenase (PF01070; HMM-score: 21.4)
    His_biosynth; Histidine biosynthesis protein (PF00977; HMM-score: 20.7)
    IMPDH; IMP dehydrogenase / GMP reductase domain (PF00478; HMM-score: 17.5)
    PK_TIM (CL0151) PEP_mutase; Phosphoenolpyruvate phosphomutase (PF13714; HMM-score: 16.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9931
    • Cytoplasmic Membrane Score: 0.0004
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0063
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.025841
    • TAT(Tat/SPI): 0.001939
    • LIPO(Sec/SPII): 0.001253
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MMKRTWRNSFVTNLNTPFMIGNIEIPNRTVLAPMAGVTNSAFRTIAKELGAGLVVMEMVSDKGIQYNNEKTLHMLHIDEGENPVSIQLFGSDEDSLARAAEFIQENTKTDIVDINMGCPVNKIVKNEAGAMWLKDPDKIYSIINKVQSVLDIPLTVKMRTGWADPSLAVENALAAEAAGVSALAMHGRTREQMYTGHADLETLYKVAQALTKIPFIANGDIRTVQEAKQRIEEVGADAVMIGRAAMGNPYLFNQINHYFETGEILPDLTFEDKMKIAYEHLKRLINLKGENVAVREFRGLAPHYLRGTSGAAKLRGAISQASTLAEIEALLQLEKA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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