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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7466
  • locus tag: DQM66_RS00735 [old locus tag: NCTC7466_00133 ]
  • pan locus tag?: PNEUPAN000824000
  • symbol: cibB
  • pan gene symbol?: cibB
  • synonym:
  • product: fratricide two-peptide bacteriocin subunit CibB

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: DQM66_RS00735 [old locus tag: NCTC7466_00133 ]
  • symbol: cibB
  • product: fratricide two-peptide bacteriocin subunit CibB
  • replicon: chromosome
  • strand: -
  • coordinates: 137824..137976
  • length: 153
  • essential: unknown

Accession numbers[edit | edit source]

  • Location: NZ_LS483374 (137824..137976) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0132 PneumoBrowse

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    ATGATGAAAAATTTGAACAACTATCGTGAAATTTCTAATAAGGAATTGCAAGAAATCAAG
    GGTGGCTTTGGTGTAGGTGTTGGTATCGCTTTATTTATGGCAGGTTATACCATTGGAAAA
    GACCTTCGTAAAAAGTTTGGTAAGTCATGCTAG
    60
    120
    153

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: DQM66_RS00735 [old locus tag: NCTC7466_00133 ]
  • symbol: CibB
  • description: fratricide two-peptide bacteriocin subunit CibB
  • length: 50
  • theoretical pI: 10.3274
  • theoretical MW: 5556.54
  • GRAVY: -0.282

Function[edit | edit source]

  • TIGRFAM:
    class IIb bacteriocin, lactobin A/cerein 7B family (TIGR03949; HMM-score: 19.1)
    bacteriocin-type signal sequence (TIGR01847; HMM-score: 18.4)
    and 1 more
    Cellular processes Cellular processes Biosynthesis of natural products natural product precursor, GG-Bacteroidales family (TIGR04149; HMM-score: 13.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    GG-leader (CL0400) ComC; COMC family (PF03047; HMM-score: 24.1)
    Bacteriocin_IIc; Bacteriocin class II with double-glycine leader peptide (PF10439; HMM-score: 20.9)
    and 3 more
    Lactococcin; Lactococcin-like family (PF04369; HMM-score: 15.3)
    no clan defined DUF5841; Family of unknown function (DUF5841) (PF19159; HMM-score: 14.1)
    GG-leader (CL0400) L_biotic_typeA; Type-A lantibiotic (PF04604; HMM-score: 12.9)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Extracellular
    • Cytoplasmic Score: 0.24
    • Cytoplasmic Membrane Score: 0.05
    • Cellwall Score: 0.8
    • Extracellular Score: 8.91
    • Internal Helix: 1
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.161508
    • TAT(Tat/SPI): 0.009079
    • LIPO(Sec/SPII): 0.074357
  • predicted transmembrane helices (TMHMM): 1

Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000977347 NCBI
  • UniProt:

Protein sequence[edit | edit source]

  • MMKNLNNYREISNKELQEIKGGFGVGVGIALFMAGYTIGKDLRKKFGKSC

Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

Expression data[edit | edit source]

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]