PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 12-FEB-2025

⊟Summary

• organism: Streptococcus pneumoniae NU83127
• locus tag: EL277_RS03480 [old locus tag: SPNU_0650 ]
• pan locus tag^?: PNEUPAN001605000
• symbol: divIB
• pan gene symbol^?: divIB
• synonym:
• product: cell division protein DivIB

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: EL277_RS03480 [old locus tag: SPNU_0650 ]
• symbol: divIB
• product: cell division protein DivIB
• replicon: chromosome
• strand: +
• coordinates: 667184..668383
• length: 1200
• essential: unknown

⊟Accession numbers

• Location: NZ_AP018936 (667184..668383) NCBI
• BioCyc: EL277_RS03480 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0600 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  
  ATGTCAAAAGATAAGAAAAATGAGGACAAAGAAACCCTCGAAGAATTGAAAGAGTTATCA
  GAATGGCAGAAACGAAACCAAGAATATCTAAAAAAGAAGGCTGAAGAAGAGGCGGCTCTA
  GCTGAGGAGAAGGAAAAGGAAAGACAAGCTCGAATGGGAGAAGAATCTGAGAAGTCAGAG
  GATAAACAGGACCAGGAGAGTGAAACAGACCAGGAAGATTCAGAATCAGCTAAGGAAGAG
  TCTGAAGAAAAAGTAGCATCCTCAGAGGCTGACAAAGAGAAAGAAGAGAAAGAAGAACCA
  GAGTCTAAAGAGAAGGAGGAACAGGATAAAAAGCTTGCTAAAAAGGCTACAAAGGAAAAA
  CCAGCCAAAGCAAAGATTCCTGGTATCCATATCTTGCGAGCCTTCACGATTTTATTTCCA
  AGTCTGCTTCTATTGTTTGTCTCTGCCTACTTGCTCAGTCCTTATGCGACCATGAAAGAT
  ATTCGTGTTGAGGGAACGGTGCAAACTACAGCTGATGATATTCGACAGGCTTCAGGCATT
  CAGGATTCGGATTATACGATTAACCTTCTGCTAGACAAGGCAAAATATGAAAAGCAGATT
  AAGTCTAACTATTGGGTTGAATCAGCTCAACTTGTCTATCAATTTCCAACTAAGTTCACT
  ATTAAGGTCAAGGAATATGATATTGTGGCCTACTATATTTCTGGTGAAAATCATTATCCT
  ATTCTTTCCAGTGGTCAGCTTGAGACTAGTTCTGTGAGTCTGAACAGTTTACCAGAAACT
  TATTTATCAGTTCTCTTTAATGATAGTGAACAAATCAAAGTTTTTGTCTCAGAACTTGCT
  CAAATTAGCCCAGAACTCAAGGCGGCTATCCAAAAGGTGGAATTAGCCCCAAGCAAGGTG
  ACATCCGATTTAATTCGATTGACCATGAATGATTCGGACGAAGTCTTGGTTCCTCTATCT
  GAAATGAGTAAGAAACTGCCATATTACAGTAAGATTAAGCCTCAATTGTCAGAACCGAGT
  GTGGTCGACATGGAAGCTGGAATCTACAGCTACACTGTGGCGGATAAATTAATTATGGAA
  GCTGAGGAAAAAGCCAAACAAGAGGCCAAGGAAGCTGAGAAAAAACAAGAAGAAGAACAG
  AAAAAACAAGAGGAAGAGAGCAATCGAAACCAAACGACCCAGCGTTCATCGCGTCGCTAG
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  

⊟Protein

⊟General

• locus tag: EL277_RS03480 [old locus tag: SPNU_0650 ]
• symbol: DivIB
• description: cell division protein DivIB
• length: 399
• theoretical pI: 4.56912
• theoretical MW: 45778.9
• GRAVY: -0.958647

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Cations and iron carrying compounds ferrous iron transport protein B (TIGR00437; HMM-score: 6.4)
  and 1 more
  pullulanase, extracellular (TIGR02102; HMM-score: 3.7)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  POTRA (CL0191) POTRA_1; POTRA domain, FtsQ-type (PF08478; HMM-score: 64.9)
  and 7 more
  no clan defined Saf4_Yju2; Saf4/Yju2 protein (PF04502; HMM-score: 13.5)
  Otopetrin; Otopetrin (PF03189; HMM-score: 11.3)
  Peptidase_AD (CL0130) Presenilin; Presenilin (PF01080; HMM-score: 10.2)
  no clan defined Na_trans_assoc; Sodium ion transport-associated (PF06512; HMM-score: 8.5)
  SAPS; SIT4 phosphatase-associated protein (PF04499; HMM-score: 7.2)
  TORC_M; Transducer of regulated CREB activity middle domain (PF12885; HMM-score: 6.5)
  DMT (CL0184) Zip; ZIP Zinc transporter (PF02535; HMM-score: 5.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cellwall
  • Cytoplasmic Score: 0.11
  • Cytoplasmic Membrane Score: 0.93
  • Cellwall Score: 8.19
  • Extracellular Score: 0.77
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 0.9961
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0037
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.00708
  • TAT(Tat/SPI): 0.003615
  • LIPO(Sec/SPII): 0.002379
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI:
• RefSeq: WP_000031159 NCBI
• UniProt:

⊟Protein sequence

• MSKDKKNEDKETLEELKELSEWQKRNQEYLKKKAEEEAALAEEKEKERQARMGEESEKSEDKQDQESETDQEDSESAKEESEEKVASSEADKEKEEKEEPESKEKEEQDKKLAKKATKEKPAKAKIPGIHILRAFTILFPSLLLLFVSAYLLSPYATMKDIRVEGTVQTTADDIRQASGIQDSDYTINLLLDKAKYEKQIKSNYWVESAQLVYQFPTKFTIKVKEYDIVAYYISGENHYPILSSGQLETSSVSLNSLPETYLSVLFNDSEQIKVFVSELAQISPELKAAIQKVELAPSKVTSDLIRLTMNDSDEVLVPLSEMSKKLPYYSKIKPQLSEPSVVDMEAGIYSYTVADKLIMEAEEKAKQEAKEAEKKQEEEQKKQEEESNRNQTTQRSSRR

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0600 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications