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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 09-MAY-2015
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae NCTC7465
- locus tag: ERS445053_00999 [new locus tag: AT689_RS05120 ]
- pan locus tag?: PNEUPAN003307000
- symbol: atxA
- pan gene symbol?: mga2
- synonym: mgaSpn
- product: transcriptional activator
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: ERS445053_00999 [new locus tag: AT689_RS05120 ]
- symbol: atxA
- product: transcriptional activator
- replicon: chromosome
- strand: +
- coordinates: 942594..944066
- length: 1473
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: LN831051 (942594..944066) NCBI
- BioCyc: see AT689_RS05120
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_1587 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1441ATGAGAGATTTATTATCTAAAAAAAGTCATAGGCAATTAGAATTATTATTTGAACATAAA
CGTTGGTTTCATCGTTCTGAACTAGCAGAGTTATTAAATTGTACAGAACGTGCAGTCAAA
GATGATCTATCCCATGTTAAATCTGCTTTTCCTGACTTGATTTTTCATTCTTCTACTAAT
GGTATACGCATTATTAATACCGATGATAGTGATATTGAAATGGTTTACCATCATTTCTTT
AAACATTCAACTCATTTTTCGATTTTAGAATTCATCTTCTTTAATGAAGGTTGTCAAGCT
GAGAGTATTTGTAAAGAATTTTATATCAGTTCATCTTCGCTCTATCGTATTATTAGCCAA
ATCAATAAAGTGATTAAAAGGCAATTTCAATTTGAAGTCAGTCTGACCCCTGTTCAAATC
ATTGGAAATGAGAGAGACATTCGTTACTTTTTTGCACAATATTTTTCAGAAAAATATTAT
TTCCTAGAATGGCCATTTGAAAATTTTTCATCAGAGCCACTATCTCAATTGTTAGAATTG
GTTTATAAGGAAACAAGCTTTCCAATGAATTTGTCAACGCATAGAATGCTAAAGTTGCTC
CTAGTTACGAACCTATATAGAATAAAGTTTGGTCATTTTATGGAAGTAGATAAAGATTCT
TTTAACGACCAAAGTTTGGATTTTTTAATGCAGGCAGAAGGAATAGAAGGTGTTGCTCAG
AGTTTTGAATCAGAATACAATATCTCTTTAGATGAAGAAGTTGTTTGCCAATTATTTGTG
TCTTACTTTCAAAAAATGTTTTTCATAGATGAAAGTCTCTTTATGAAATGCGTAAAAAAG
GATAGTTATGTTGAAAAATCTTACCATCTATTGAGTGATTTTATTGATCAGATTTCAGTC
AAGTATCAGATTGAAATTGAGAATAAGGATAATCTGATTTGGCATCTGCATAATACCGCA
CATCTGTATCGTCAAGAGTTGTTTACTGAGTTTATTTTATTTGATCAAAAAGGGAATACA
ATCAGGAACTTTCAAAATATTTTTCCAAAATTTGTTTCAGATGTAAAAAAAGAGCTTTCT
CACTATTTAGAGACTCTTGAGGTTTGTTCTAGTTCAATGATGGTAAATCATCTATCTTAT
ACCTTCATCACTCATACCAAACATTTGGTAATTAATTTGCTACAAAATCAGCCTAAACTA
AAGGTTTTGGTTATGAGTAATTTTGATCAGTATCATGCAAAATTCGTTGCAGAGACACTT
TCTTATTACTGTAGCAATAATTTTGAACTGGAAGTTTGGACTGAATTAGAATTATCAAAG
GAATCTTTAGAAGATTCATCTTATGATATCATTATTTCTAATTTTATTATTCCTCCTATT
GAAAATAAGAGACTCATCTATTCAAATAATATAAACACGGTCTCACTCATATATTTGTTA
AATGCCATGATGTTTATTCGATTAGATGAGTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: ERS445053_00999 [new locus tag: AT689_RS05120 ]
- symbol: AtxA
- description: transcriptional activator
- length: 490
- theoretical pI: 5.548
- theoretical MW: 58357.3
- GRAVY: -0.181837
⊟Function[edit | edit source]
- TIGRFAM:
- TheSEED: data available for D39, Hungary19A-6, TIGR4
- PFAM: PRD (CL0166) PRD_Mga; M protein trans-acting positive regulator (MGA) PRD domain (PF08270; HMM-score: 357.6)and 5 moreHTH (CL0123) Mga; Mga helix-turn-helix domain (PF05043; HMM-score: 94.5)HTH_Mga; M protein trans-acting positive regulator (MGA) HTH domain (PF08280; HMM-score: 57.8)HTH_11; HTH domain (PF08279; HMM-score: 21.9)no clan defined YozE_SAM_like; YozE SAM-like fold (PF06855; HMM-score: 16.1)HTH (CL0123) HTH_7; Helix-turn-helix domain of resolvase (PF02796; HMM-score: 15.5)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.6768
- Cytoplasmic Membrane Score: 0.3036
- Cell wall & surface Score: 0.0006
- Extracellular Score: 0.019
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.002744
- TAT(Tat/SPI): 0.000651
- LIPO(Sec/SPII): 0.000931
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: COT16021 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MRDLLSKKSHRQLELLFEHKRWFHRSELAELLNCTERAVKDDLSHVKSAFPDLIFHSSTNGIRIINTDDSDIEMVYHHFFKHSTHFSILEFIFFNEGCQAESICKEFYISSSSLYRIISQINKVIKRQFQFEVSLTPVQIIGNERDIRYFFAQYFSEKYYFLEWPFENFSSEPLSQLLELVYKETSFPMNLSTHRMLKLLLVTNLYRIKFGHFMEVDKDSFNDQSLDFLMQAEGIEGVAQSFESEYNISLDEEVVCQLFVSYFQKMFFIDESLFMKCVKKDSYVEKSYHLLSDFIDQISVKYQIEIENKDNLIWHLHNTAHLYRQELFTEFILFDQKGNTIRNFQNIFPKFVSDVKKELSHYLETLEVCSSSMMVNHLSYTFITHTKHLVINLLQNQPKLKVLVMSNFDQYHAKFVAETLSYYCSNNFELEVWTELELSKESLEDSSYDIIISNFIIPPIENKRLIYSNNINTVSLIYLLNAMMFIRLDE
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1587 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Carolyn Hemsley, Elizabeth Joyce, David L Hava, Amita Kawale, Andrew Camilli
MgrA, an orthologue of Mga, Acts as a transcriptional repressor of the genes within the rlrA pathogenicity islet in Streptococcus pneumoniae.
J Bacteriol: 2003, 185(22);6640-7
[PubMed:14594838] [WorldCat.org] [DOI] (P p)Virtu Solano-Collado, Manuel Espinosa, Alicia Bravo
Activator role of the pneumococcal Mga-like virulence transcriptional regulator.
J Bacteriol: 2012, 194(16);4197-207
[PubMed:22661692] [WorldCat.org] [DOI] (I p)