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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 28-AUG-2013

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_11782 [new locus tag: HMPREF0837_RS08530 ]
  • pan locus tag?: PNEUPAN002831000
  • symbol: HMPREF0837_11782
  • pan gene symbol?: pclA
  • synonym:
  • product: Gram-positive signal peptide protein, YSIRK family

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_11782 [new locus tag: HMPREF0837_RS08530 ]
  • symbol: HMPREF0837_11782
  • product: Gram-positive signal peptide protein, YSIRK family
  • replicon: chromosome
  • strand: -
  • coordinates: 1632414..1638035
  • length: 5622
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    3661
    3721
    3781
    3841
    3901
    3961
    4021
    4081
    4141
    4201
    4261
    4321
    4381
    4441
    4501
    4561
    4621
    4681
    4741
    4801
    4861
    4921
    4981
    5041
    5101
    5161
    5221
    5281
    5341
    5401
    5461
    5521
    5581
    ATGAAACATTCACATAAAAAATCATTTGACTGGTATAGCATGCAACAACGTTATTCTATT
    CGTAAGTATTACTTTGGTGCAGTTAGTGTCTTGCTCGGTACCGCTTTGGTATTAGGTGCA
    GCAGCTAGTGTCCAAACAGTACAAGCGGAAGAAAACAAACAAGAAACTACCAATAGTATT
    TCTGTTGGTAGGGGAGAAGCAGCTACTAAACTAGCAGAGGTTTCTGCGTCTAATAAAGAG
    AAAACCTATGCAGCTCCAACTGTAGCTAATCCAGTAGAAACGACTCCAGTTAAAACTGGA
    GAAGTTACTAAACCAGCAGAAAAAGTTGAAGAAGCAAAAGACAAAAAAGAGGAAGTAACG
    CATCAAGATGCTATTGACAAGTCAAAATTGTTAACGGCTCTTTCGCGTGCTAAAAAGTTA
    GAAAGCAAGTTATATACAGAAGCAAGTGCTGCTAACTTGCAAACAAGTATCCAAGCTGGT
    CAAAGCTTGCTTGGGAAAGCAGATGCATCTGAAGCTGAATTATCAGCAGCAGAGTCATCT
    ATTCAATCATCTATTATTGGTCTAGAACTTCGTTCTAACTCTAACAAAGGAACTGTATCA
    GAAACTCCTGTAGCGAAGAAAGCTAATATAGTTGAAGCGAAGGAAGAGACTAATCCAGCT
    GCAACAACTGATCGTTCAGCTGTTGATAGTGCTGTTTTGCCAACTAGCACAGCTGCCAAA
    GTAGAAACAACTTCAGCTCCAGCATCTATTAATGAAATCTTGAAACCAGGTTTGAGCCTT
    TCTGATGCTCGCCAAAATCCAGCTATCCGTAAAGAAGACTTGGATAAGGGGTATAGTGGT
    TTTAGAGCAGCACCTGCTCCAACGAACAAACTAGTAACTAATCTAGGAAATAATACTGTT
    TTCACTGATATTAGCAGAGGGTCTCATACTTTCCGTGGTAATGGGAATTCACGTGGTGGA
    AACCCGATTCATTTTGATGTAACAACAACTAGAGTTGGAAATAGAGTAGAATTCTCAATT
    GCATATTCTGGTCCAGGTGAGTTCGTTAATAATAACTTTCTCTTAGACAAAGGGAATGGA
    TTTGGAGAACCATCTCGTGCAACTATTTCAACAAACAGATTAAGAGATCAAACTAAAGAT
    ATAAGAAAGGGTGCAAATTTTGTATCTCATTCAAGCTACAGTTTAACATCTGCTGTTGAA
    ACAAACAGTAATCAAACTATTAGATTTAGTTTACCTATAGCCAACCCTAATGGTGATCTG
    TCTGTTCGATTAAGACCTGTTACTTTTAATGTAGGTCAAGGGGAATCAGGATCTGCAACT
    AGTAATGATCCATATAGTAACTCTAACTATTACTTCAGAGAAAAACCACTCCTCTTGGAT
    GCAAATCCAAATGGTGGTACTAATAATAAGACTGTTTCAGAAGACATTGACTTCCAAACT
    GTCTATCTTCCAACTAGTAAGTTACCAGAAGGTCAAACTAGATTAGTTCGAGAAGGTGAA
    AAAGGACAACGTCAAATCATCTATAAAGTTCATCAATTGGGTAACGAAACAATCCTAGGA
    TTGCCAATTAGTAATTCAGTTATTAAAGAAGTTAAGCCACGTATTATGCAAATTGGTGTG
    GCTAAAGATCTAATCGATACAGTAAAACCACGTGTTGATCAAAATAAAGTCGGTGATACA
    AATAACCTCACTTTCTATCTTGATAACGATGGAAACGGTGTTTATACTGAGGGCGTAGAC
    GAACTTGTTCAAAAAATTGCTATTAAAGATGGTGCTAAAGGTGAAAAAGGAGTCCAAGGC
    GAACGCGGCCTGACTGGAGCGCAAGGTCAGGCAGGTCGTGACGGTGTAACTCCAACCGTA
    ACCGTTAAAGATAATAAAAATGACGGCACTCATACTATCACTATTAACGACGGTAGAGGT
    AATGTTGCAAGTACTGTTGTAAGAGATGGTTTCGATGGCGCAAGTCCATTAGTTGCGACT
    CAACGAAATGAAGCAGATAAGACAACAACTGTTATCTTCTATTATGATCAAAATGGAAAT
    AATGAATTAGATGCTTCTGATAAGAAATTAAAAGAAGTTATTATTGCAGATGGTGCCAAA
    GGTGAACAAGGTCTTCAAGGTCGTGATGGAGCTCAAGGACCAAAAGGAGAACAAGGTAAT
    CCAGGAACTCCAGGTAAAGATGGAAAATCTCTAATTGCTGTTAAAAATGGAACTGAAACA
    AAAGTATATGTAGAGGATCCGGCTAGACCAGGACAACCACTTAATCCAAACCAACCATTA
    GCAACTATCACTGATGGAAGAAATGGTACTAATGGACAATCACCAACAATTACAGCGACA
    CGAAGTGTTCAAAATGGTAAAAATGGTGTATTAGTAACAATTACACCAGTAGGAGGTCGT
    CCACAAACAACATTTGTAGAGGATGGACAAAAAGGTGCTGATGGGAAAACCCCAACAGTA
    ACAATAACTGAGGGGCAAAACGGCACACATACATTAACGGTTCATAATCCAGGAAGTCCA
    GATGTGACAACTACGATCCGTGATGGAGCTACAGGACAAGCAGGTCGTGATGGTAAAGAT
    GTATTAAACGGAAAAGTAAATCCACAACCAAACCAAGGTAAAAATGGAGATAAATATATT
    AATACCGAAACCGGTGATGTCTATGTTAAAAACAATGGAAACTGGGATAAAGAAGGCAAC
    ATCAAAGGCCCTAAAGGGGACAAAGGTGCAGATGGTGCTAAAGGCGAAAAAGGAGACCAA
    GGCGAACGCGGCCTAACTGGAGCGCAAGGAGCTAAAGGTGCGGATGGCGCAGTAGGTCGT
    GATGGACGTGACGGTAAAGACGTGTTGAACGGCAAAGCTAACCCAGAAGCACATCAAGGT
    AAAGACGGCGATAAATACGTTAATACAGAAACAGGCGACGTCTTCGTTAAGAATAACGGC
    AACTGGGATAAAGAGGGCAACATCAAAGGCCCTAAGGGTGACAAAGGTGAACGCGGAGAA
    GATGGTAAGACTCCAGAAGTAACTGTAACTCCAGGTAAAGATGGCCATAGTACTGACATT
    ACATTCACTGTTCCAGGTAAAGATCCAGTTACAGTAAATGTTAAGGACGGAGAAAATGGT
    CTGAACGGTAAAACTCCAAAAGTTGATTTACTTCGTGTCCAAGGAAAAAACGGAAATCCA
    TCTCATACAATTGTGACATTCTATACAGATGAAAACAATGACGGCAAATATACACCAGGA
    ACTGATGAACTTCTAGGTTCAGAAATGATTAAAGATGGTGCTAAAGGCGCGGACGGACGA
    GATGGTAAATCATTGCTTACTGTCAAGGATGGTAAAGAAACTAAAGTTTACCAAGAAGAT
    CCAGCTAACCCAGGACAACCATTAAATCCAGAAAAACCACTTGCGGTAATTAGAGATGGA
    GTAGATGGAAAATCACCTACAGTTACAGCTGTTCGTAAAGATGAAGCAGGGCATAAAGGT
    GTAGAAATCACTGTTGATAACCATGATGGTTCACAACCAACTACAGTCTTTGTTCAAGAT
    GGTGCTAAGGGAGAAACTGGTGCAATCGGTCAGGATGGACAAACTCCTACAATCACTACT
    CAACGTGGACAAGATGGCCAAAGCACTGTTGTAACTATCACAACACCAGGTAAAGATCCA
    GTAACCTTCACTGTAAAAGATGGTAAGAATGGTAAAGATGGCCGTGCACCGAAAATCAAA
    GTAGAAGATATTACTTCACCTTCAAGAATTAGACGCGCTACAGATGCTGCTGCAACTCCA
    ACGCGTAACGGTATCCGTGTTACAGTTTATGATGATGTTAATGACAATGGGGTATACGAC
    GGAGGTGTCGATAAAGTATTAAATAGTAAAGATATTTATAACGGTATAGATGGACGTGAT
    GGTTCAGCTCCAACTATTACTACAAAAGATAATGGAGATGGAACACACACTATCACAGTT
    CAAAATCCTGATGGTTCTGAATCAACAACTGTTGTTAAAGATGGTAAAGACGGTAAAACT
    GCGAATATCACTACAACAGAAAACCCAGATGGAAGCCACACAATTACGGTGACAAATCCA
    GATGGTTCAACTAAAGAAACTGTTGTTAAAAACGGTAAAGACGGTAAGACTCCTAAAGTT
    GAAGTAACGGATAACAACGATGGAACTCACACAGTTAAAGTGACGGATGGAGACGGTAAT
    GTAACGAACGCTATCATCAAAGATGGTAAAGATGGTAAAGCTGCAACAGCAACAACTACT
    GAAAATCCAGATGGAAGCCACACAGTAACAATCACTAACCCAGACGGAACTAAGAATGAG
    TTTGTTGTTAAGAATGGACGTGACGGTGTTGACGGACGTACTCCAACCGCATCTGTTCGT
    GATAATGGAGACGGAAGTCATACAATCGTTATTACAAATCCAGAAGGTGTGACAACTGAA
    ACCACAGTTCGTGATGGTAAATCACCAAAAGTGACTATAACTGATGAACAAAATGGAACT
    CATAAGATCTCTGTTCTAAATGGTGACGGAACAACTACTGAAACAATCATTAAAGATGGT
    AAATCACCAGTAGCAACAGTTAGAGATAACCAAGATGGTACTTACACTATTCGTGTGGAA
    AATGGTAATGGTACTGTTTCTGAAACCACAGTTCGTGACGGTAAATCACCAACTGCTAAG
    GTTGTGGATAACGGAGATGGAACACACACTATCACAGTTGTGAACTCAGACGGAACAACT
    ACAACAACTACAGTTCGTTATGGTAGAGAACCAAAACTTGAAGTTATTGATAACAACGAT
    GGTTCACACACTATTAAAGTGACAGGTGCTGATGGTAAAGAAACGACAACTACAATCTTT
    GATGGTAAATCACCAAAAGCGAACATCGTTGATAACGGAGATGGAACTCATACATTAACA
    ATCGTAGATTCTGATGGTCGTGAATACAAATCTATTATTAAAGATGGTAAAGACGGCAAA
    GATGGCGTTTCACCAACTGTAACTGTTGAAAATAATAACGATGGAACTCACGTTGTTACA
    ATCACTAATCCAGATGGAAGTAAGACAGAAATGGTGATTAAAGACGGTAAAGATGGTAAA
    TCACCAAAAGTTTCTGTTGAAGATAATGGTGATGGTAGTCATACAATCACAATCATCAAT
    TCTGATGGAACTGTGACAAAAACAGTTATTAAAGATGGCAAAGATGGTAGAGATGGACGT
    GATGGTAGAGACGGCAAAGATGGAAAATGTGGATGCCAAGACAAACCAGTAACACCATCA
    AATGACAAACCAGTACCTCCAGCACCAAATGTGCCGACACCAGAAGTACTGGTTAAACCT
    GTGCCAGCGCAACCAACACCAAATGTACCGACACCAGAAGTGCCAGTACAACCAACTCCA
    GCTGTTCCAACACCAGAAGTACCGGTTCCAGAACAACCAGTAGTACCAACACCGGCTCAA
    CCAGCAACTCCAGTAAATGCTAATCCAGTAGCACCAACTACAGGTAAAGAAAACCGTGGG
    GATAAATTACCTGAAACTGGAAGCCAATCTGATTATATCTCTGTTCTTTTAGGTAGCGGT
    ATTCTATTGAGCCTATATGTAGGACGAAGAAAAGAAGATTAA
    60
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    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
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    840
    900
    960
    1020
    1080
    1140
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    1260
    1320
    1380
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    1920
    1980
    2040
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    2160
    2220
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    2520
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    2640
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    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3240
    3300
    3360
    3420
    3480
    3540
    3600
    3660
    3720
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    3900
    3960
    4020
    4080
    4140
    4200
    4260
    4320
    4380
    4440
    4500
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    4620
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    4800
    4860
    4920
    4980
    5040
    5100
    5160
    5220
    5280
    5340
    5400
    5460
    5520
    5580
    5622

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_11782 [new locus tag: HMPREF0837_RS08530 ]
  • symbol: HMPREF0837_11782
  • description: Gram-positive signal peptide protein, YSIRK family
  • length: 1873
  • theoretical pI: 5.60979
  • theoretical MW: 197086
  • GRAVY: -0.793006

⊟Function[edit | edit source]

  • TIGRFAM:
    Streptococcal surface-anchored protein repeat, S. criceti family (TIGR04203; HMM-score: 540)
    and 3 more
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 35.6)
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 17)
    Por secretion system C-terminal sorting domain (TIGR04183; HMM-score: 12)
  • TheSEED  :
    • Flagellar hook-length control protein FliK
  • PFAM:
    no clan defined CFSR; Collagen-flanked surface repeat (PF19079; HMM-score: 577.1)
    and 8 more
    Collagen; Collagen triple helix repeat (20 copies) (PF01391; HMM-score: 48.2)
    G5 (CL0593) G5; G5 domain (PF07501; HMM-score: 39.9)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 33.3)
    E-set (CL0159) BiPBP_C; Penicillin-Binding Protein C-terminus Family (PF06832; HMM-score: 33.3)
    no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 14.4)
    DUF4860; Domain of unknown function (DUF4860) (PF16152; HMM-score: 11.4)
    PGDYG; PGDYG protein (PF14083; HMM-score: 10.4)
    E-set (CL0159) Por_Secre_tail; Secretion system C-terminal sorting domain (PF18962; HMM-score: 8.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 9.99
    • Extracellular Score: 0.01
    • Internal Helix: 1
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0004
    • Cytoplasmic Membrane Score: 0.0011
    • Cell wall & surface Score: 0.9846
    • Extracellular Score: 0.0138
  • SignalP: Signal peptide SP(Sec/SPI) length 49 aa
    • SP(Sec/SPI): 0.947738
    • TAT(Tat/SPI): 0.02451
    • LIPO(Sec/SPII): 0.005982
    • Cleavage Site: CS pos: 49-50. VQA-EE. Pr: 0.9032
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADI70010 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKHSHKKSFDWYSMQQRYSIRKYYFGAVSVLLGTALVLGAAASVQTVQAEENKQETTNSISVGRGEAATKLAEVSASNKEKTYAAPTVANPVETTPVKTGEVTKPAEKVEEAKDKKEEVTHQDAIDKSKLLTALSRAKKLESKLYTEASAANLQTSIQAGQSLLGKADASEAELSAAESSIQSSIIGLELRSNSNKGTVSETPVAKKANIVEAKEETNPAATTDRSAVDSAVLPTSTAAKVETTSAPASINEILKPGLSLSDARQNPAIRKEDLDKGYSGFRAAPAPTNKLVTNLGNNTVFTDISRGSHTFRGNGNSRGGNPIHFDVTTTRVGNRVEFSIAYSGPGEFVNNNFLLDKGNGFGEPSRATISTNRLRDQTKDIRKGANFVSHSSYSLTSAVETNSNQTIRFSLPIANPNGDLSVRLRPVTFNVGQGESGSATSNDPYSNSNYYFREKPLLLDANPNGGTNNKTVSEDIDFQTVYLPTSKLPEGQTRLVREGEKGQRQIIYKVHQLGNETILGLPISNSVIKEVKPRIMQIGVAKDLIDTVKPRVDQNKVGDTNNLTFYLDNDGNGVYTEGVDELVQKIAIKDGAKGEKGVQGERGLTGAQGQAGRDGVTPTVTVKDNKNDGTHTITINDGRGNVASTVVRDGFDGASPLVATQRNEADKTTTVIFYYDQNGNNELDASDKKLKEVIIADGAKGEQGLQGRDGAQGPKGEQGNPGTPGKDGKSLIAVKNGTETKVYVEDPARPGQPLNPNQPLATITDGRNGTNGQSPTITATRSVQNGKNGVLVTITPVGGRPQTTFVEDGQKGADGKTPTVTITEGQNGTHTLTVHNPGSPDVTTTIRDGATGQAGRDGKDVLNGKVNPQPNQGKNGDKYINTETGDVYVKNNGNWDKEGNIKGPKGDKGADGAKGEKGDQGERGLTGAQGAKGADGAVGRDGRDGKDVLNGKANPEAHQGKDGDKYVNTETGDVFVKNNGNWDKEGNIKGPKGDKGERGEDGKTPEVTVTPGKDGHSTDITFTVPGKDPVTVNVKDGENGLNGKTPKVDLLRVQGKNGNPSHTIVTFYTDENNDGKYTPGTDELLGSEMIKDGAKGADGRDGKSLLTVKDGKETKVYQEDPANPGQPLNPEKPLAVIRDGVDGKSPTVTAVRKDEAGHKGVEITVDNHDGSQPTTVFVQDGAKGETGAIGQDGQTPTITTQRGQDGQSTVVTITTPGKDPVTFTVKDGKNGKDGRAPKIKVEDITSPSRIRRATDAAATPTRNGIRVTVYDDVNDNGVYDGGVDKVLNSKDIYNGIDGRDGSAPTITTKDNGDGTHTITVQNPDGSESTTVVKDGKDGKTANITTTENPDGSHTITVTNPDGSTKETVVKNGKDGKTPKVEVTDNNDGTHTVKVTDGDGNVTNAIIKDGKDGKAATATTTENPDGSHTVTITNPDGTKNEFVVKNGRDGVDGRTPTASVRDNGDGSHTIVITNPEGVTTETTVRDGKSPKVTITDEQNGTHKISVLNGDGTTTETIIKDGKSPVATVRDNQDGTYTIRVENGNGTVSETTVRDGKSPTAKVVDNGDGTHTITVVNSDGTTTTTTVRYGREPKLEVIDNNDGSHTIKVTGADGKETTTTIFDGKSPKANIVDNGDGTHTLTIVDSDGREYKSIIKDGKDGKDGVSPTVTVENNNDGTHVVTITNPDGSKTEMVIKDGKDGKSPKVSVEDNGDGSHTITIINSDGTVTKTVIKDGKDGRDGRDGRDGKDGKCGCQDKPVTPSNDKPVPPAPNVPTPEVLVKPVPAQPTPNVPTPEVPVQPTPAVPTPEVPVPEQPVVPTPAQPATPVNANPVAPTTGKENRGDKLPETGSQSDYISVLLGSGILLSLYVGRRKED

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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