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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 19-SEP-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TCH8431/19A
  • locus tag: HMPREF0837_RS09170 [old locus tag: HMPREF0837_11916 ]
  • pan locus tag?: PNEUPAN003071000
  • symbol: HMPREF0837_RS09170
  • pan gene symbol?: nanR
  • synonym:
  • product: MurR/RpiR family transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HMPREF0837_RS09170 [old locus tag: HMPREF0837_11916 ]
  • symbol: HMPREF0837_RS09170
  • product: MurR/RpiR family transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 1757229..1758080
  • length: 852
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014251 (1757229..1758080) NCBI
  • BioCyc: HMPREF0837_RS09170 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1487 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGGACAAACCAGATATCGCAACTGTCATTGATTCACACTTTGAAGAAATGACAGACCTA
    GAGCAAGAAATCGCTCGCTATTTTTTGCAAGCTGAAACGATTAAAGATGATTTATCTTCC
    CAACATGTCACTCAAAAATTACATATCTCTCAGGCTGCTTTGACCCGCTTTGCTAAAAAG
    TGTGGCTTTACTGGCTACCGAGAATTTATTTTCCAATACCAACATGAAGCAGAAAATCAA
    GCCAACCAAGTCTCCAAGCACAGTCCACTGACCAAACGAGTCCTCAGAAGTTATAGCAAT
    ATGAGGGAACAAACACAAGACTTGATTGACGAAGTCCAACTAGAACGAATTGCCCAGCTA
    ATCGAAGAGGCTGAGCGTATCTACTTCTTCGGAACAGGGAGTTCTGGTCTTGTTGCTCGT
    GAAATGAAATTGCGCTTCATGCGTCTGGGTGTTGTCTGCGAAGCTTTGACAGACCAAGAC
    GGCTTTGCTTGGACAACCAGTATTATGGATGAAAATTGTCTCGTACTCGGTTTCTCACTT
    TCTGGCACAACTCCTTCTATTTTAGATAGTCTATTAGACGCTAAGGAGATGGGCGCAAAG
    ACTGTACTTTTTTCAAGTGTTCCCAATAAAGATAGTCAGGCCTACACAGAGACTGTTCTT
    GTAGCCACCCACAGCCAGTCTTCTTACATCCAACGTATATCCGCTCAACTTCCTATGCTC
    TTCTTTATCGATTTGATTTACGCCTACTTTTTGGAAATCAATCGTGAAAGTAAGGAGAAA
    ATCTTTAATAGCTACTGGGAAAATAAAAAACTCAACGGCTATCGTAGACAAAAACGTGTC
    AGAAAATCCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    852

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HMPREF0837_RS09170 [old locus tag: HMPREF0837_11916 ]
  • symbol: HMPREF0837_RS09170
  • description: MurR/RpiR family transcriptional regulator
  • length: 283
  • theoretical pI: 6.26265
  • theoretical MW: 32653.9
  • GRAVY: -0.388693

⊟Function[edit | edit source]

  • TIGRFAM:
    6-phospho 3-hexuloisomerase (TIGR03127; EC 5.3.-.-; HMM-score: 53)
    and 5 more
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan N-acetylmuramic acid 6-phosphate etherase (TIGR00274; EC 4.2.1.126; HMM-score: 20.6)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 17.5)
    Metabolism Central intermediary metabolism Amino sugars glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 17.5)
    bifunctional phosphoglucose/phosphomannose isomerase (TIGR02128; EC 5.3.1.9; HMM-score: 16.9)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides phosphoheptose isomerase (TIGR00441; EC 5.3.1.28; HMM-score: 13.5)
  • TheSEED: see HMPREF0837_11916
  • PFAM:
    SIS (CL0067) SIS; SIS domain (PF01380; HMM-score: 53.4)
    HTH (CL0123) HTH_6; Helix-turn-helix domain, rpiR family (PF01418; HMM-score: 47)
    and 4 more
    SIS (CL0067) SIS_2; SIS domain (PF13580; HMM-score: 30.2)
    no clan defined DUF6756; Family of unknown function (DUF6756) (PF20541; HMM-score: 14.3)
    HO (CL0230) TENA_THI-4; TENA/THI-4/PQQC family (PF03070; HMM-score: 14.2)
    no clan defined RNase_E_G; Ribonuclease E/G family (PF10150; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by NanR*, TF important in Sialic acid utilization: in TIGR4

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004618
    • TAT(Tat/SPI): 0.002171
    • LIPO(Sec/SPII): 0.000291
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MDKPDIATVIDSHFEEMTDLEQEIARYFLQAETIKDDLSSQHVTQKLHISQAALTRFAKKCGFTGYREFIFQYQHEAENQANQVSKHSPLTKRVLRSYSNMREQTQDLIDEVQLERIAQLIEEAERIYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQDGFAWTTSIMDENCLVLGFSLSGTTPSILDSLLDAKEMGAKTVLFSSVPNKDSQAYTETVLVATHSQSSYIQRISAQLPMLFFIDLIYAYFLEINRESKEKIFNSYWENKKLNGYRRQKRVRKS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Muhammad Afzal, Sulman Shafeeq, Hifza Ahmed, Oscar P Kuipers
Sialic acid-mediated gene expression in Streptococcus pneumoniae and role of NanR as a transcriptional activator of the nan gene cluster.
Appl Environ Microbiol: 2015, 81(9);3121-31
[PubMed:25724955] [WorldCat.org] [DOI] (I p)

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