PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 26-OCT-2021

⊟Summary

• organism: Streptococcus pneumoniae R6
• locus tag: SPR_RS07530 [old locus tag: spr1518 ]
• pan locus tag^?: PNEUPAN003071000
• symbol: SPR_RS07530
• pan gene symbol^?: nanR
• synonym:
• product: MurR/RpiR family transcriptional regulator

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPR_RS07530 [old locus tag: spr1518 ]
• symbol: SPR_RS07530
• product: MurR/RpiR family transcriptional regulator
• replicon: chromosome
• strand: +
• coordinates: 1496473..1497324
• length: 852
• essential: unknown

⊟Accession numbers

• Location: NC_003098 (1496473..1497324) NCBI
• BioCyc: see spr1518
• MicrobesOnline: see spr1518
• PneumoBrowse for strain D39V: SPV_1487 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  
  ATGGACAAACCAGATATCGCAACTATCATTGATTCACATTTTGAAGAAATGACAGACCCA
  GAGCAAGAAATCGCTCGCTATTTTTTGCAAGCTGAAACGATTACAGATGATTTATCTTCT
  CAACAAGTCACCCAAAAATTACATATTTCTCAAGCTGCTTTGACCCGCTTTGCTAAAAAG
  TGTGGCTTTACTGGCTACCGAGAATTTATTTTCCAATACCAACATCAGGCAGAAAATCAA
  GCCAACCAAGTTTCCAAGCACAGTCCACTGACCAAACGAGTCCTCAGAAGTTATAGCAAT
  ATGAGGGAACAAACACAAGACTTGATTGACGAAATCCAACTAGAACGAATTGCCCAGCTA
  ATCGAAGATGCTGAGCGTATCTACTTCTTTGGAACAGGGAGTTCTGGCCTCGTCGCCCGT
  GAAATGAAATTACGTTTTATGCGATTAGGTGTGGTCTGCGAAGCTTTGACAGACCAAGAC
  GGCTTTGCCTGGACAACCAGCATCATGGATGAAAATTGTCTAGTACTGGGCTTCTCACTT
  TCAGGCTCAACTCCTTCTATTTTAGATAGTCTATTAGATGCCAAGGAGATGGGGGCAAAG
  ACTGTACTCTTTACAAGTGTTCCCAATAAAAATAGCCAGACCTATACAGAGACTGTTCTT
  GTAGCCACCCACAGCCAACCCTCCTATATCCAACGAATATCCGCTCAACTTCCTATGCTC
  TTCTTTATCGATTTGATTTATGCCTACTTTTTGGAAATCAATCGCGAAAGCAAGGAAAAA
  ATCTTTAATAGCTACTGGGAAAATAAAAAACTCAACGGCTATCGTAGACAAAAACGTGTA
  AGAAAATCCTAG
  60
  120
  180
  240
  300
  360
  420
  480
  540
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  720
  780
  840
  852
  

⊟Protein

⊟General

• locus tag: SPR_RS07530 [old locus tag: spr1518 ]
• symbol: SPR_RS07530
• description: MurR/RpiR family transcriptional regulator
• length: 283
• theoretical pI: 6.3716
• theoretical MW: 32653.9
• GRAVY: -0.407067

⊟Function

• TIGRFAM:
  6-phospho 3-hexuloisomerase (TIGR03127; EC 5.3.-.-; HMM-score: 53.3)
  and 7 more
  Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan N-acetylmuramic acid 6-phosphate etherase (TIGR00274; EC 4.2.1.126; HMM-score: 19.9)
  bifunctional phosphoglucose/phosphomannose isomerase (TIGR02128; EC 5.3.1.9; HMM-score: 18.2)
  Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 17.7)
  Metabolism Central intermediary metabolism Amino sugars glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 17.7)
  RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 14.3)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides phosphoheptose isomerase (TIGR00441; EC 5.3.1.28; HMM-score: 14)
  rad50 (TIGR00606; HMM-score: 10.5)
• TheSEED: see spr1518
• PFAM:
  SIS (CL0067) SIS; SIS domain (PF01380; HMM-score: 59)
  HTH (CL0123) HTH_6; Helix-turn-helix domain, rpiR family (PF01418; HMM-score: 50.7)
  and 2 more
  SIS (CL0067) SIS_2; SIS domain (PF13580; HMM-score: 31.6)
  Transthyretin (CL0287) DUF3869; Domain of unknown function (DUF3869) (PF12985; HMM-score: 14.7)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:
• genes regulated by NanR*, TF important in Sialic acid utilization: see spr1518

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.008274
  • TAT(Tat/SPI): 0.001159
  • LIPO(Sec/SPII): 0.000398
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000360342 NCBI
• UniProt: see spr1518

⊟Protein sequence

• MDKPDIATIIDSHFEEMTDPEQEIARYFLQAETITDDLSSQQVTQKLHISQAALTRFAKKCGFTGYREFIFQYQHQAENQANQVSKHSPLTKRVLRSYSNMREQTQDLIDEIQLERIAQLIEDAERIYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQDGFAWTTSIMDENCLVLGFSLSGSTPSILDSLLDAKEMGAKTVLFTSVPNKNSQTYTETVLVATHSQPSYIQRISAQLPMLFFIDLIYAYFLEINRESKEKIFNSYWENKKLNGYRRQKRVRKS

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: no polycistronic organisation predicted

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1487 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications

Muhammad Afzal, Sulman Shafeeq, Hifza Ahmed, Oscar P Kuipers
Sialic acid-mediated gene expression in Streptococcus pneumoniae and role of NanR as a transcriptional activator of the nan gene cluster.
Appl Environ Microbiol: 2015, 81(9);3121-31
[PubMed:25724955] [WorldCat.org] [DOI] (I p)