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serotype 4
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EF3030
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670-6B
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BVJ1JL
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CGSP14
serotype 14
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serotype 19F
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Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
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R6
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SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-JAN-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_RS08525 [old locus tag: SPCG_1646 ]
  • pan locus tag?: PNEUPAN003071000
  • symbol: SPCG_RS08525
  • pan gene symbol?: nanR
  • synonym:
  • product: MurR/RpiR family transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPCG_RS08525 [old locus tag: SPCG_1646 ]
  • symbol: SPCG_RS08525
  • product: MurR/RpiR family transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 1619128..1619979
  • length: 852
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGGACAAACCAGATATCGCAACTGTCATTGATTCACATTTTGAAGAAATGACAGACCTA
    GAGCAAGAAATCGCTCGCTATTTTTTACAAGCAGAAACCATTCAAGATGACCTTTCCTCC
    CAACAGGTCACTCAAAAATTACATATCTCTCAAGCTGCACTGACCCGCTTTGCTAAAAAG
    TGTGGCTTTACTGGCTACCGAGAATTTATTTTCCAATACCAACATGAGGCAGAAAATCAA
    GCCAACCAAGTCTCCAAGCACAGTCCACTGACCAAACGAGTCCTCAGAAGCTATAGTAAT
    ATGAGGGAACAAACACAAGACTTGATTGACGAAGTCCAACTAGAACGAATTGCCCAATTA
    ATCGAAGATGCTGAGCGTGTCTACTTCTTCGGAACAGGAAGTTCTGGCCTTGTTGCTCGT
    GAAATGAAATTACGCTTCATGCGTCTGGGTGTGGTCTGCGAAGCTTTGACCGATCAAGAC
    GGCTTTGCCTGGACAACCAGCATTATGGACGAAAATTGTCTCGTACTTGGTTTCTCACTT
    TCAGGCTCAACTCCTTCTATTTTAGATAGTCTATTGGATGCCAAGGAGATGGGAGCAAAG
    ACTGTACTCTTTTCAAGTGTTCCCAATAAAGATAGCCAGGCCTATACTGAGACCGTTCTT
    GTAGCTACCCACAGCCAGCCTTCCTACATCCAACGTATATCCGCTCAACTTCCTATGCTC
    TTCTTTATCGATTTGATTTATGCCTACTTTTTGGAAATCAATCGTGAAAGCAAGGAGAAA
    ATCTTTAATAGCTATTGGGAAAATAAGAAACTCAACGGCTATCGTAGACAAAAACGTGTC
    AGAAAATCCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    852

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_RS08525 [old locus tag: SPCG_1646 ]
  • symbol: SPCG_RS08525
  • description: MurR/RpiR family transcriptional regulator
  • length: 283
  • theoretical pI: 5.73367
  • theoretical MW: 32612.8
  • GRAVY: -0.392579

⊟Function[edit | edit source]

  • TIGRFAM:
    6-phospho 3-hexuloisomerase (TIGR03127; EC 5.3.-.-; HMM-score: 51.7)
    and 7 more
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan N-acetylmuramic acid 6-phosphate etherase (TIGR00274; EC 4.2.1.126; HMM-score: 19.2)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 16.8)
    Metabolism Central intermediary metabolism Amino sugars glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 16.8)
    bifunctional phosphoglucose/phosphomannose isomerase (TIGR02128; EC 5.3.1.9; HMM-score: 14.8)
    RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 14)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides phosphoheptose isomerase (TIGR00441; EC 5.3.1.28; HMM-score: 12.4)
    rad50 (TIGR00606; HMM-score: 9.9)
  • TheSEED: see SPCG_1646
  • PFAM:
    SIS (CL0067) SIS; SIS domain (PF01380; HMM-score: 52.8)
    HTH (CL0123) HTH_6; Helix-turn-helix domain, rpiR family (PF01418; HMM-score: 48.8)
    and 4 more
    SIS (CL0067) SIS_2; SIS domain (PF13580; HMM-score: 30.9)
    no clan defined RNase_E_G; Ribonuclease E/G family (PF10150; HMM-score: 13.4)
    DUF6756; Family of unknown function (DUF6756) (PF20541; HMM-score: 12.8)
    Transthyretin (CL0287) DUF3869; Domain of unknown function (DUF3869) (PF12985; HMM-score: 12.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by NanR*, TF important in Sialic acid utilization: see SPCG_1646

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006801
    • TAT(Tat/SPI): 0.001604
    • LIPO(Sec/SPII): 0.000294
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MDKPDIATVIDSHFEEMTDLEQEIARYFLQAETIQDDLSSQQVTQKLHISQAALTRFAKKCGFTGYREFIFQYQHEAENQANQVSKHSPLTKRVLRSYSNMREQTQDLIDEVQLERIAQLIEDAERVYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQDGFAWTTSIMDENCLVLGFSLSGSTPSILDSLLDAKEMGAKTVLFSSVPNKDSQAYTETVLVATHSQPSYIQRISAQLPMLFFIDLIYAYFLEINRESKEKIFNSYWENKKLNGYRRQKRVRKS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Muhammad Afzal, Sulman Shafeeq, Hifza Ahmed, Oscar P Kuipers
Sialic acid-mediated gene expression in Streptococcus pneumoniae and role of NanR as a transcriptional activator of the nan gene cluster.
Appl Environ Microbiol: 2015, 81(9);3121-31
[PubMed:25724955] [WorldCat.org] [DOI] (I p)

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