PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 02-AUG-2013

⊟Summary

• organism: Streptococcus pneumoniae gamPNI0373
• locus tag: HMPREF1038_00724 [new locus tag: HMPREF1038_RS03555 ]
• pan locus tag^?: PNEUPAN001651000
• symbol: HMPREF1038_00724
• pan gene symbol^?: glnH3
• synonym:
• product: amino acid ABC transporter substrate binding protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: HMPREF1038_00724 [new locus tag: HMPREF1038_RS03555 ]
• symbol: HMPREF1038_00724
• product: amino acid ABC transporter substrate binding protein
• replicon: chromosome
• strand: -
• coordinates: 664812..665603
• length: 792
• essential: unknown

⊟Accession numbers

• Location: CP001845 (664812..665603) NCBI
• BioCyc: see HMPREF1038_RS03555
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0615 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  
  GTGGAAACGCTGGTTCATCCTCTGGAAAAACAACTGCCAAAGCTCGCACTATCGATGAAA
  TCAAAAAAAAGCGGTGAACTGCGAATCGCCGTGTTTGGAGATAAAAAACCGTTTGGCTAC
  GTTGACAATGATGGTTCTTACCAAGGCTACGATATTGAACTAGGGAACCAACTAGCTAAA
  GACCTTGGTGTCAAGGTTAAATACATTTCAGTCGATGCTGCCAACCGTGCGGAATACTTG
  ATTTCAAACAAGGTAGATATTACTCTTGCTAACTTTACAGTAACTGACGAACGTAAGAAA
  CAAGTTGATTTTGCCCTTCCATATATGAAAGTTTCTCTGGGTGTCGTATCACCTAAGACT
  GGTCTCATTACAGACGTCAAACAACTTGAAGGTAAAACCTTAATTGTCACAAAAGGAACG
  ACTGCTGAGACTTATTTTGAAAAGAATCATCCAGAAATCAAACTCCAAAAATACGACCAA
  TACAGTGACTCTTACCAAGCTCTTCTTGACGGACGTGGAGATGCCTTTTCAACTGACAAT
  ACGGAAGTTCTAGCTTGGGCGCTTGAAAATAAAGGATTTGAAGTAGGAATTACTTCCCTC
  GGTGATCCCGATACCATTGCGGCAGCAGTTCAAAAAGGCAACCAAGAATTGCTAGACTTC
  ATCAATAAAGATATTGAAAAATTAGGCAAGGAAAACTTCTTCCACAAGGCCTATGAAAAA
  ACACTTCACCCAACCTACGGTGACGCTGCTAAAGCAGATGACCTGGTTGTTGAAGGTGGA
  AAAGTTGATTAG
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  792
  

⊟Protein

⊟General

• locus tag: HMPREF1038_00724 [new locus tag: HMPREF1038_RS03555 ]
• symbol: HMPREF1038_00724
• description: amino acid ABC transporter substrate binding protein
• length: 263
• theoretical pI: 5.08234
• theoretical MW: 29109.7
• GRAVY: -0.432319

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Amino acids, peptides and amines lysine-arginine-ornithine-binding periplasmic protein (TIGR01096; HMM-score: 129)
  and 4 more
  extracellular substrate-binding orphan protein, GRRM family (TIGR04262; HMM-score: 62.3)
  Metabolism Transport and binding proteins Amino acids, peptides and amines ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB (TIGR02995; HMM-score: 36)
  quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein (TIGR03871; HMM-score: 13.9)
  Metabolism Transport and binding proteins Other ABC transporter, substrate-binding protein, aliphatic sulfonates family (TIGR01728; HMM-score: 12.7)
• TheSEED  :
  • Lysine-arginine-ornithine-binding periplasmic protein precursor (TC 3.A.1.3.1)
  Amino Acids and Derivatives Arginine; urea cycle, polyamines Arginine and Ornithine Degradation  Lysine-arginine-ornithine-binding periplasmic protein precursor (TC 3.A.1.3.1)
• PFAM:
  PBP (CL0177) SBP_bac_3; Bacterial extracellular solute-binding proteins, family 3 (PF00497; HMM-score: 168.4)
  and 4 more
  Lig_chan-Glu_bd; Ligated ion channel L-glutamate- and glycine-binding site (PF10613; HMM-score: 37.1)
  Hybrid (CL0105) Biotin_lipoyl; Biotin-requiring enzyme (PF00364; HMM-score: 14.7)
  PBP (CL0177) NMT1; NMT1/THI5 like (PF09084; HMM-score: 14.5)
  OpuAC; Substrate binding domain of ABC-type glycine betaine transport system (PF04069; HMM-score: 14.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.018457
  • TAT(Tat/SPI): 0.000981
  • LIPO(Sec/SPII): 0.002158
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: AFS42790 NCBI
• UniProt:

⊟Protein sequence

• METLVHPLEKQLPKLALSMKSKKSGELRIAVFGDKKPFGYVDNDGSYQGYDIELGNQLAKDLGVKVKYISVDAANRAEYLISNKVDITLANFTVTDERKKQVDFALPYMKVSLGVVSPKTGLITDVKQLEGKTLIVTKGTTAETYFEKNHPEIKLQKYDQYSDSYQALLDGRGDAFSTDNTEVLAWALENKGFEVGITSLGDPDTIAAAVQKGNQELLDFINKDIEKLGKENFFHKAYEKTLHPTYGDAAKADDLVVEGGKVD

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0615 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications