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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 08-SEP-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae BM6001
  • locus tag: ODS73_RS04035 [old locus tag: ODS73_04035 ]
  • pan locus tag?: PNEUPAN001712000
  • symbol: ODS73_RS04035
  • pan gene symbol?: ppiA
  • synonym:
  • product: peptidylprolyl isomerase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: ODS73_RS04035 [old locus tag: ODS73_04035 ]
  • symbol: ODS73_RS04035
  • product: peptidylprolyl isomerase
  • replicon: chromosome
  • strand: -
  • coordinates: 774618..775421
  • length: 804
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP107038 (774618..775421) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0672 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGAAAAAACTAGCAACCCTTCTTTTACTGTCTACTGTAGCCCTAGCTGGGTGTAGCAGC
    GTCCAACGCAGTCTGCGTGGTGATGATTATGTTGATTCCAGTCTTGCTGCTGAAGAAAGT
    TCCAAAGTAGCTGCCCAATCTGCCAAGGAGTTAAACGATGCATTAACAAACGAAAACGCC
    AATTTCCCACAACTATCTAAGGAAGTTGCTGAAGATGAAGCCGAAGTGATTCTCCACACA
    AGCCAAGGTGATATTCGCATTAAACTCTTCCCTAAACTCGCTCCTCTAGCGGTTGAAAAT
    TTCCTCACTCATGCCAAAGAAGGCTACTATAACGGTATTACCTTCCACCGTGTCATCGAT
    GGCTTTATGGTCCAAACTGGAGATCCAAAAGGGGACGGTACAGGTGGTCAGTCCATCTGG
    CATGACAAGGATAAGACTAAAGACAAAGGAACTGGTTTCAAGAACGAGATTACTCCTTAT
    TTGTATAACATCCGTGGTGCTCTTGCTATGGCTAATACTGGTCAACCAAACACCAATGGC
    AGCCAGTTCTTCATCAACCAAAGCTCTACAGATACCTCTTCTAAACTCCCTACAAGCAAG
    TATCCACAGAAAATTATCGAAGCCTACAAAGAAGGTGGAAACCCTAGTCTAGATGGCAAA
    CACCCAGTCTTTGGTCAAGTGATTGACGGTATGGATGTTGTGGATAAGATTGCTAAGGCC
    GAAAAAGATGAAAAAGACAAGCCAACTACTGCTATCACAATCGACAGCATCGAAGTGGTG
    AAAGACTACGATTTTAAATCTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    804

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: ODS73_RS04035 [old locus tag: ODS73_04035 ]
  • symbol: ODS73_RS04035
  • description: peptidylprolyl isomerase
  • length: 267
  • theoretical pI: 5.20225
  • theoretical MW: 29039.3
  • GRAVY: -0.507865

⊟Function[edit | edit source]

  • reaction:
    EC 5.2.1.8?  ExPASy
    Peptidylprolyl isomerase Peptidylproline (omega=180) = peptidylproline (omega=0)
  • TIGRFAM:
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    Cyclophil-like (CL0475) Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (PF00160; HMM-score: 180)
    and 1 more
    LppaM (CL0421) LPAM_1; Prokaryotic membrane lipoprotein lipid attachment site (PF08139; HMM-score: 14.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Extracellular
    • Cytoplasmic Score: 0.0065
    • Cytoplasmic Membrane Score: 0.0727
    • Cell wall & surface Score: 0.001
    • Extracellular Score: 0.9198
  • SignalP: Signal peptide LIPO(Sec/SPII) length 17 aa
    • SP(Sec/SPI): 0.000871
    • TAT(Tat/SPI): 0.000095
    • LIPO(Sec/SPII): 0.998774
    • Cleavage Site: CS pos: 17-18. LAG-CS. Pr: 0.9994
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000731922 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKLATLLLLSTVALAGCSSVQRSLRGDDYVDSSLAAEESSKVAAQSAKELNDALTNENANFPQLSKEVAEDEAEVILHTSQGDIRIKLFPKLAPLAVENFLTHAKEGYYNGITFHRVIDGFMVQTGDPKGDGTGGQSIWHDKDKTKDKGTGFKNEITPYLYNIRGALAMANTGQPNTNGSQFFINQSSTDTSSKLPTSKYPQKIIEAYKEGGNPSLDGKHPVFGQVIDGMDVVDKIAKAEKDEKDKPTTAITIDSIEVVKDYDFKS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Peter W M Hermans, Peter V Adrian, Christa Albert, Silvia Estevão, Theo Hoogenboezem, Ingrid H T Luijendijk, Thilo Kamphausen, Sven Hammerschmidt
The streptococcal lipoprotein rotamase A (SlrA) is a functional peptidyl-prolyl isomerase involved in pneumococcal colonization.
J Biol Chem: 2006, 281(2);968-76
[PubMed:16260779] [WorldCat.org] [DOI] (P p)

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