PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

⊟Summary

• pan ID^?: PNEUPAN002294000
• symbol^?: zmpA
• synonym: iga
• description^?: immunoglobulin A1 protease

  descriptions from strain specific annotations:

  • immunoglobulin A1 protease
  • ZmpA/ZmpB/ZmpC family metallo-endopeptidase
  • peptidase M26
  • G5 domain-containing protein
  • Gram-positive signal peptide protein, YSIRK family
  • IgA1 protease
  • IgA1 protease ZmpA
  • IgA-protease
  • YSIRK signal domain/LPXTG anchor domain surface protein
  • YSIRK-type signal peptide-containing protein
  • pseudogene
• strand^?: +
• coordinates^?: 2864826..2875904
• occurrence^?: in 49% of 43 strains

⊟Orthologs

(4)^?
TIGR4:
—
(2)
D39:
—
(2)
D39V:
SPV_RS04870 (iga)
(19A)
Hungary19A-6:
SPH_RS05955
(19F)
EF3030:
EF3030_RS05665
(6B)^?
670-6B:
SP670_RS05930 (iga)
(6A)
6A-10:
—
(5)
70585:
—
(19F)
A026:
T308_RS05580 (iga)
(3)
A66:
—
(11A)
AP200:
SPAP_RS05230
(12F)
ASP0581:
EL334_RS05610 (iga)
(19F)
ATCC 49619:
EL263_RS05660 (iga)
(23F)
ATCC 700669:
—
(19F)
BM6001:
ODS73_RS05765 (iga)
(1)
BVJ1JL:
—
(14)
CGSP14:
SPCG_RS05920
(19F)
G54:
SPG_RS05310
(1)
gamPNI0373:
HMPREF1038_RS05140
(3)
HU-OH:
—
(19A)
Hu15:
SPNHU15_RS05460
(19A)
Hu17:
SPNHU17_RS05385
(1)
INV104:
—
(14)
INV200:
SPNINV200_RS05740
(14)
JJA:
—
(19F)
MDRSPN001:
MDRSPN_RS05145 (iga)
(1)
NCTC7465:
—
(2)
NCTC7466:
DQM66_RS04880 (iga)
(4)
NU83127:
—
(3)
OXC141:
—
(1)
P1031:
—
(2)
R6:
—
(19A)
SP49:
BMJ42_RS06145 (iga)
(1)
SPN032672:
—
(3)
SPN034156:
—
(3)
SPN034183:
—
(3)
SPN994038:
—
(3)
SPN994039:
—
(3)
SPNA45:
—
(19F)
ST556:
MYY_RS06060 (iga)
(19F)
Taiwan19F-14:
SPT_RS05850 (iga)
(19A)
TCH8431/19A:
HMPREF0837_RS06435 (iga)
(4)
Xen35:
—

⊟Genome Viewer

D39V
Hungary19A-6
EF3030

⊟Alignments

• alignment of orthologues:
  CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
  
  
  D39V            MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQETAGVHYKYVADSELSS
  Hungary19A-6    MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQETAGVHYKYVADSELSS
  EF3030          MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQETAGVHYKYVADSELSS
                  ************************************************************
  
  D39V            EEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSKNERQALVAGASLAALGIL
  Hungary19A-6    EEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSKNERQALVAGASLAALGIL
  EF3030          EEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSKNERQALVAGASLAALGIL
                  ************************************************************
  
  D39V            IFAVSKKKVKNKTVLHLVLVAGMGNGVLVSVHALENHLLLNYNTDYELTSGEKLPLPKEI
  Hungary19A-6    IFAVSKKKVKNKTVLHLVLVAGIGNGVLVSVHALENHLLLNYNTDYELTSGEKLPLPKEI
  EF3030          IFAVSKKKVKNKTVLHLVLVAGIGNGVLVSVHALENHLLLNYNTDYELTSGEKLPLPKEI
                  **********************:*************************************
  
  D39V            SGYTYIGYIKEGKTTSDFEVSNQEKSAATPTKQQKVDYNVTPNFVDHPSTVQAIQEQTPV
  Hungary19A-6    SGYTYIGYIKEGKTTSDFEVSNQEKSAATPTKQQKVDYNVTPNFVDHPSTVQAIQEQTPV
  EF3030          SGYTYIGYIKEGKTTSDFEVSNQEKSAATPTKQQKVDYNVTPNFVDHPSTVQAIQEQTPV
                  ************************************************************
  
  D39V            SSTKPTEVQVVEKPFSTELINPRKEEKQSSDSQEQLAEHKNLETKKEEKISPKEKTGVNT
  Hungary19A-6    SSTKPTEVQVVEKPFSTELINPRKEEKQSSDSQEQLAEHKNLETKKEEKISPKEKTGVNT
  EF3030          SSTKPTEVQVVEKPFSTKLINPRKEEKQSSDSQEQLAEHKNLETKKEEKISPKEKTGVNT
                  *****************:******************************************
  
  D39V            LNPQDEVLSGQLNKPELLYREETIETKIDFQEEIQENPDLAEGTVRVKQEGKLGKKVEIV
  Hungary19A-6    LNPQDEVLSGQLNKPELLYREETIEIKIDFQEEIQENPDLVEGIVRVKQEGKLGKKVEIV
  EF3030          LNPQDEVLSGQLNKPELLYREETIETKIDFQEETQENPDLAEGTVRVKQEGKLGKKVEIV
                  ************************* ******* ******.** ****************
  
  D39V            RIFSVNKEEVSREIVSTSTTAPSPRIVEKGTKKTQVIKEQPETGVEHKDVQSGAIVEPAI
  Hungary19A-6    RIFSVNKEEVSREIVSTSTTAPIPRIVEKGTKKTQVIKEQPETGVEHKDVQSGAIVEPAI
  EF3030          RIFSVNKEEVSREIVSTSTTAPSPRIVEKGTKKTQVIKEQPETGVEHKDVQSGAIVEPAI
                  ********************** *************************************
  
  D39V            QPELPEAVVSDKGEPEVQPTLPEAVVTDKGETEVQPESPDTVVSDKGEPEQVAPLPEY--
  Hungary19A-6    QPELPEAVVSDKGVPEVQPALSKAVITDKGETEVQPESPDTVVSDKGEPAVQPESPDTVV
  EF3030          QPELPEAVVSDKGVPEVQPALSEAVVTDKGEPAVQPELSEAVVTDKGEPAVQPELSEAVV
                  ************* *****:*.:**:*****. **** .::**:*****   .  .:   
  
  D39V            --KGNIEQVKPETPVEKTKEQGPEKTEEVPVKPTEETPVNPNEGTTEGTSIQEAENPVQP
  Hungary19A-6    SDKGEPKQVAP-LP-EYT---GPQAS--AIVEPEQVAPLPEYTGVQAGAIVEPA---VQP
  EF3030          TDKG-----------------------------------------------EPA---VQP
                    **                                               : *   ***
  
  D39V            AEESTTNSEKVSPDTSSENTGEVSSNPSDSTTSVGESNKPEHNDSKNENSEKTVEEVPVN
  Hungary19A-6    ALPEAVVSDKGVPEVQPELPEAVV-------------------------SDKGVPEVQPE
  EF3030          ELPEAVVSDKGEPAVQPELPEAVV-------------------------TDKGETEVQPE
                     .:. *:*  * ...* .  *                          ::*   **  :
  
  D39V            PNEGTVEGTSNQETEKPVQPAEETQT-------NSGKIAN--ENTG---------EVSNK
  Hungary19A-6    LPEAVV---SDKGEPEQVAPLPEYKG-------NIEQVKP--ET----------------
  EF3030          SPDTVV---SDKGEPKQVAPLPEYTGPQASAIVEPEQVAPLPEYTGVQAGSIVEPEKVEA
                    : .*   *::   : * *  *          :  ::    *                 
  
  D39V            PSDS----KPPVEESNQPEKNGTATKPENSGNTTSENGQTEPEKKLELRNVSDIELYSQT
  Hungary19A-6    ----------PVEKLQ----------------------EEEPEKTIELRSVSDVELYSYE
  EF3030          PKEYTGKIEQPSAEDTKPENEASSTNGESERPKDKIKEEKQVDKKLELRNVSNVELYTVE
                            *  :                        : : :*.:***.**::***:  
  
  D39V            NGTYRQHVSLDGIPENTDTYFVKVKSSAFKDVYIPVASITEEKRNGQSVYKITAKAEKLQ
  Hungary19A-6    ANQSKQHTILDKVPDNKSAYFIKVKSAKFKDVLLPVSNIEDTTKDGKVVYKITARLEHLK
  EF3030          NNKYRHITAVDGALDSSLKYFMKVKSENFKDIMLPVTKIESTTKNNKEVYKIVAHAENLI
                   .  :: . :*   :..  **:****  ***: :**:.* . .::.: ****.*: *:* 
  
  D39V            QELENKYVDNFTFYLDKKAKEENTNFTSFSNLVKAINQNPSGTYHLAASLNANEVELGPD
  Hungary19A-6    QSVDNQYQDNFTYYLPKVVQNDGPIYTSFKKLVTDMNSRPDGTFILGATMNAREFELGEN
  EF3030          QHENNVISNDYTYYLPKTQQSETGVYTSFKNLVDAMNSDPNGTFHLGATMDAREVELPDD
                  *  :*   :::*:** *  :.:   :***.:**  :*. *.**: *.*:::*.*.**  :
  
  D39V            ERSYIKDTFTGRLIGEKDGKNYAIYNLKKPLFENLSGATVEKLSLKNVAISGKNDIGSLA
  Hungary19A-6    QESYVTKNFTGTLIGSHQGKHYAIYNLKKPLFNTLNNAAIQDLTLKDVNISGKNHVASVA
  EF3030          QESYVKNEFYGKLIGENNGKYYAIYNLKKPLFKTLNTATIQNLSIKEANVSSKEDAATIS
                  :.**:.. * * ***.::** ***********:.*. *:::.*::*:. :*.*:. .:::
  
  D39V            NEATNGTKIKQVHVDGVLAGERGVGGLLAKADQSSIAESSFKGRIVNTYETTDAYNIGGL
  Hungary19A-6    MEATNSSTLDNVHANGIIAGELGIGGLVQKVDNSTVRNSSFTGRITNTFVTTSQYAIGGL
  EF3030          KEAKYNTLIDNVHSDGIIAGERGIGGLVSKVDNSRISNSSFTGRITNTYDTTAGYEIGGL
                   **. .: :.:** :*::*** *:***: *.*:* : :***.***.**: **  * ****
  
  D39V            VGHLTGKNASIAKSKATVTISSNTNRSDQTVGGLAGLVDQDAHIQNSYAEGDINNVKHFG
  Hungary19A-6    VGQLTGANARVAHSISTVVISSNGEHSNQTIGGIVGIVENNATVENSYAEGEINNAKPFA
  EF3030          VGKLSGSLASIEKSIASIDIASNAKSGDQIVGGIAGVVEKSATIKYSYVEGNVNNVRHFG
                  **:*:*  * : :* ::: *:** : .:* :**:.*:*::.* :: **.**::**.: *.
  
  D39V            KVAGVAGYLWDRTSGEEKHAGELTNVLSDVNVTNGNAITGYHYTGMKVANTFSSKANRVF
  Hungary19A-6    RVGGVAGSLWTQEGGTDNNTGRLTNVLSDMNITNGNAISGYHFNGIKETNVYSNKENKVV
  EF3030          KVGGVAGNLWDRDSQDVSKSGKLSYVLSDVNVTNGNAIAGYNFNGIKTIETYSNKNNKVV
                  :*.**** ** : .   .::*.*: ****:*:******:**::.*:*  :.:*.* *:*.
  
  D39V            NVTLEKDEVVSKESFEERGTMLDASQIVSKKAEINPLTLPTVEPLSTSGKKDSDFSKIAH
  Hungary19A-6    NVQAVGDEVMSVDSTVERGTEIEKTSVQAKKDEITKKHTITVEDFTNSVKQDVDYTKAAH
  EF3030          NVVQEDDEVVTKDSDVQRGTVLDADKVKEKKVELVSKHSTKVEDFDFTSRYNTNYNEVTG
                  **    ***:: :*  :*** ::  .:  ** *:      .** :  : : : ::.: : 
  
  D39V            YQANRALVYKNIEKLLPFYNKSTIVKYGNLVKENSLLYQKELLSAVMMKDDQVITDIVSN
  Hungary19A-6    YQSTREVAYKNIEKLLPFYNRDTIVKYGNQLSTDHNLFKKELLSVVAMKNDEVVSDITSN
  EF3030          YQQSREQVYKNIEKLLPFYNRETIVKYGNLVEDNSDLFTKKLLSVVPMKNNEVITDINKN
                  ** .*  .************:.******* :. :  *: *:***.* **:::*::** .*
  
  D39V            KQTANKLLLHYNDHSSEKFDLKYQTDFANLAEYNLGNTGLLYTPNQFLYDRDSIVKEVLP
  Hungary19A-6    KNSINHLLLHYKDGTSEKVDLTYNSDFANLAEYNIENTGLVYTPNAFLKNYTPIIDRVKN
  EF3030          KQEINKLLLHFEGNKSRVLNIAYKNDFSKVAEYDIANTKLMYTPNTMLHDYNNIVKTILN
                  *:  *:****::. .*. .:: *:.**:::***:: ** *:**** :* :   *:. :  
  
  D39V            ELQKLDYQSDAIRKTLGISPEVKLTELYLEDQFSKTKQNLGDSLKKLLSADAG-LASDNS
  Hungary19A-6    DLTAVPYNPTALKNLLGISDNVKLTELYLDEQFTKTKEHLTETLKKLLSADAA-VSGNND
  EF3030          DLKSVQYSSADVRKVLDISGNIKLTELYLGEQFEKTKANIEDSLSKLLTADAAIVENNNK
                  :*  : *..  ::: *.** ::******* :** *** :: ::*.***:***. : .:*.
  
  D39V            VTRGYLVDKIKNNKEALLLGLTYLERWYNFNYGQVNVKDLVMYHPDFFGKGNTSPLDTLI
  Hungary19A-6    IIDNYIVDKIKRNKEALMLGLTYLERWYDFKFDKASAKDLLMFHMDFFGKGNTSPLDAII
  EF3030          VIDNYVIEKIKNNKEALLLGLTYLERWYNFNYGETNAKDLIMYHLDFFGKSNSSALDNVI
                  :  .*:::***.*****:**********:*::.:...***:*:* *****.*:*.** :*
  
  D39V            ELGKSGFNNLLAKNNVDTYGISLASQHGATDLFSTLEHYRKVFLPNTSNNDWFKSETKAY
  Hungary19A-6    ELGKSGYNNLLAKNNVVTYNALLTNNYGTKDLFSALEGYRKAFAPHQTNNEWFKSQTKAY
  EF3030          ELGKSGFNNLLAKNNVITYNVLLAKNYGTESLFKALEGYRKVFLPTISNNEWFKKQTKAY
                  ******:********* **.  *:.::*: .**.:** ***.* *  :**:***.:****
  
  D39V            IVEEKSTIEEVKTKQGLAGTKYSIGVYDRITSATWKYRNMVLPLLTLP-ERSVFVISTMS
  Hungary19A-6    IVEEKSNIEEVKTKQGLVGTKYSIGVYDRITSATWKYRNMVLPLLTLP-EKSVFVISTIS
  EF3030          IVEEKSTIEEGREKQGKEGTKYSIGVYDRLTNPSWKYQSMVLPLLTLPEEKTVFMIANIS
                  ******.*** : ***  ***********:*..:***:.********* *::**:*:.:*
  
  D39V            SLGFGAYDRYRSSDHKAGKALNDFVEENARETAKRQRDHYDYWYRILDEQSREKLYRTIL
  Hungary19A-6    SLGFGAYDRYRNSEHKAGKDLNDFVEENARETAKHQRDHYDYWYRILDDNAREKLYRNIL
  EF3030          TIGFGAYDRYRSSEYPKGEKLNKFVEDNAKEAAKRFRDHYDYWYKILDNDNKEKLYRSIL
                  ::*********.*::  *: **.***:**:*:**: ********:***:: :*****.**
  
  D39V            LYDAYKFGDDTTSGKATAEAKFDSSNPAMKNFFGPVGNKVVHNQHGAYATGDGVYYMSYR
  Hungary19A-6    LYDAYKFGDDNTVGKATEVADFDNPNPAMQHFFGPVGNKVGHNQHGAYATGDAVYYMGYR
  EF3030          VYDAFKFGTDKDKDKVTHQATFETDHPAIKYFFGPAGNNVVHNGHGAYATGDAFYYMAYR
                  :***:*** *.  .*.*  * *:. :**:: ****.**:* ** ********..***.**
  
  D39V            MLDKDGAITYTHEMTHDSDQDIYLGGYGRRNGLGPEFFAKGLLQAPDQPSDATITINSIL
  Hungary19A-6    MLDKDGAITYTHEMTHDSDQDIYLGGYGRRSGLGPEFFAKGLLQAPDHPDDATITINSIL
  EF3030          MLDKDGAVTYTHEMTHNSDREIYLGGYGRRSGLGPEFYAKGLLQAPDHPYDPTITINSVL
                  *******:********:**::*********.******:*********:* *.******:*
  
  D39V            KHSKSDSTEGSRLQVLDPTERFQNAADLQNYVHNMFDLIYMMEYLEGQSIVNKLSVYQKM
  Hungary19A-6    KHSKSDSTESRRLQVLDPTTRFNNADDLKQYVHNMFDVVYMLEYLEGNSILK-LDTNQKQ
  EF3030          KY--EDSENSTRLQVADPTQRFNSAEDLHNYMHNMFDVIYMLEYLEGKAVAN-LETNQKY
                  *:  .** :. **** *** **:.* **::*:*****::**:*****::: : *.. ** 
  
  D39V            AALRKIENKYVKDPADGNEVYATNVVKELTEAEARNLNSFESLIDHNILSAREYQSGDYE
  Hungary19A-6    QLLRKVTNEYHPDP-DGNKVYATNVVRNITVEEVERLRSFNDLIDNNILSSREYASGKYE
  EF3030          ELLRKIENKFDLDQ-DGNNVYATNVVRRLTMDEVNKLNSFDSLIENDIITSRGYKDQEYK
                    ***: *::  *  ***:*******:.:*  *...*.**:.**:::*:::* * . .*:
  
  D39V            RNGYYTIKLFAPIYSALSSEKGTPGDLMGRRIAYELLAAKGFKDGMVPYISNQYEEDAKQ
  Hungary19A-6    RNGYFTIKLFAPIYAALSNDDGTPGDLMGRRMAYELLAAKGFKDGMVPYISNQFEADARA
  EF3030          RNGYYTIDLFSPIYSALSGEKGTPGDLMGRRIAFELLAAKGYKEGMVPYISNQYEKDAKA
                  ****:**.**:***:***.:.**********:*:*******:*:*********:* **: 
  
  D39V            QGQTINLYGKERGLVTDELVLKKVFDGKYKTWAEFKTAMYQERVDQFGNLKQVTFKDPTK
  Hungary19A-6    NNKTITSYGKTKGLVTDTLVLQRLFNGQYNTWSDFKKAMYKERQDKFNKLNKISFKDPSQ
  EF3030          AGSKINSYGKEVGLVTDELVLEKVFNGQYKTWTQFKKDMYKEREKQFSKLNRVNFINPNN
                   ...*. ***  ***** ***:::*:*:*:**::**. **:** .:*.:*:::.* :*.:
  
  D39V            PWPSYGTKTINNVDELQALMDQAVLKDAEGPRWSNYDPEIDSAVHKLKRAIFKAYLDQTN
  Hungary19A-6    PWTRNIIKTIHSVNELQNLMNEAVRKDTETPHWYNYNPEIDSAVHKLKRAIFKAYLDQTN
  EF3030          PLSRQRNVSVTDIGVLERMIVEAVRDDAQD-DVAKFYPETNSRVLKLKKAIYKAYLDQTN
                  * .     :: .:. *: :: :** .*::     :: ** :* * ***:**:********
  
  D39V            DFRSSIFENKK
  Hungary19A-6    DFRSSIFENKK
  EF3030          DFRSSIFENKK
                  ***********