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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu17
  • locus tag: SPNHU17_RS05385 [old locus tag: SPNHU17_01164 ]
  • pan locus tag?: PNEUPAN002294000
  • symbol: SPNHU17_RS05385
  • pan gene symbol?: zmpA
  • synonym: iga
  • product: ZmpA/ZmpB/ZmpC family metallo-endopeptidase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU17_RS05385 [old locus tag: SPNHU17_01164 ]
  • symbol: SPNHU17_RS05385
  • product: ZmpA/ZmpB/ZmpC family metallo-endopeptidase
  • replicon: chromosome
  • strand: +
  • coordinates: 1075084..1080762
  • length: 5679
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP020549 (1075084..1080762) NCBI
  • BioCyc: SPNHU17_RS05385 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1018 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    3661
    3721
    3781
    3841
    3901
    3961
    4021
    4081
    4141
    4201
    4261
    4321
    4381
    4441
    4501
    4561
    4621
    4681
    4741
    4801
    4861
    4921
    4981
    5041
    5101
    5161
    5221
    5281
    5341
    5401
    5461
    5521
    5581
    5641
    ATGGAAAAGTATTTTGGTGAAAAACAAGAGCGTTTTTCATTTAGAAAATTATCAGTAGGA
    CTTGTATCTGCAACGATTTCAAGTTTATTTTTTATGTCTGTATTAGCTAGTTCATCTGTG
    GATGCTCAAGAAACTGCGGGAGTTCACTATAAATATGTGGCAGATTCAGAGCTATCATCA
    GAAGAAAAGAAGCAGCTTGTCTATGATATTCCGACATACGTGGAGAATGATGATGAAACT
    TATTATCTTGTTTATAAGTTAAATTCTCAAAATCAACTGGCGGAATTACCAAATACTGGA
    AGCAAGAATGAGAGGCAAGCCCTAGTTGCTGGTGCTAGCTTAGCTGCTCTGGGAATTTTA
    ATTTTTGCTGTTTCCAAGAAAAAGGTTAAGAATAAAACGGTATTACATTTAGTATTGGTT
    GCGGGAATAGGAAATGGTGTCTTAGTTTCAGTCCATGCTTTAGAAAATCATCTTTTGCTA
    AATTACAATACGGACTATGAATTGACCTCTGGAGAAAAATTACCTCTTCCTAAAGAGATT
    TCAGGTTACACTTATATTGGATATATCAAAGAGGGAAAAACGACTTCTGATTTTGAAGTA
    AGTAATCAAGAAAAATCAGCAGCCACTCCTACAAAACAACAAAAGGTGGATTATAATGTT
    ACACCAAATTTTGTAGACCATCCATCAACAGTACAAGCTATTCAGGAACAAACACCTGTT
    TCTTCAACTAAGCCGACAGAAGTTCAAGTAGTTGAAAAACCTTTCTCTACTGAATTAATC
    AATCCAAGAAAAGAAGAGAAACAATCTTCAGATTCTCAAGAACAATTAGCCGAACATAAG
    AATCTAGAAACGAAGAAAGAGGAGAAGATTTCTCCAAAAGAAAAGACTGGGGTAAATACA
    TTAAATCCACAGGATGAAGTTTTATCAGGTCAATTGAACAAACCTGAACTCTTATATCGT
    GAGGAAACTATAGAGATAAAAATAGATTTTCAAGAAGAAATTCAAGAAAATCCTGATTTA
    GTTGAAGGAATTGTAAGAGTAAAACAAGAAGGTAAATTAGGTAAGAAAGTTGAAATCGTC
    AGAATATTCTCTGTAAACAAGGAAGAAGTTTCGCGAGAAATTGTTTCAACTTCAACGACT
    GCGCCTATTCCAAGAATAGTCGAAAAAGGTACTAAAAAAACTCAAGTTATAAAGGAACAA
    CCTGAGACTGGTGTAGAACATAAGGACGTACAGTCTGGAGCTATTGTTGAACCCGCAATT
    CAGCCTGAGTTGCCCGAAGCTGTAGTAAGTGACAAAGGCGTACCAGAAGTTCAACCAGCG
    TTGTCCAAAGCAGTTATAACCGACAAAGGTGAGACTGAGGTTCAACCAGAGTCGCCAGAT
    ACTGTGGTAAGTGATAAAGGTGAACCAGCAGTCCAACCAGAGTCGCCAGATACTGTGGTA
    AGTGATAAAGGTGAACCTAAACAGGTAGCACCGCTTCCAGAATATACAGGACCACAAGCC
    AGCGCTATTGTTGAACCAGAGCAGGTAGCACCACTACCAGAATACACAGGGGTACAAGCC
    GGAGCTATTGTTGAACCCGCAGTCCAGCCAGCGTTACCCGAAGCAGTTGTAAGCGATAAA
    GGCGTACCAGAAGTTCAGCCTGAGTTGCCCGAAGCAGTAGTAAGTGATAAAGGCGTACCA
    GAAGTTCAGCCTGAATTACCCGAAGCAGTTGTAAGTGATAAAGGTGAACCAGAGCAGGTA
    GCACCATTGCCAGAATATAAGGGGAATATTGAGCAAGTAAAACCTGAAACTCCGGTTGAG
    AAACTTCAAGAGGAAGAACCAGAGAAAACAATAGAACTAAGAAGTGTTTCTGATGTGGAA
    CTCTATAGTTATGAAGCTAATCAATCAAAACAACATACAATCTTAGATAAAGTACCAGAT
    AATAAATCTGCTTATTTCATCAAAGTGAAGTCAGCTAAATTTAAAGATGTACTGCTCCCA
    GTTTCAAACATTGAGGACACTACAAAAGACGGTAAAGTAGTCTATAAAATTACAGCTAGA
    TTGGAACACTTAAAACAATCTGTAGACAATCAATACCAAGATAATTTTACTTATTATCTT
    CCAAAAGTTGTTCAAAACGATGGCCCTATCTACACATCATTTAAAAAATTAGTAACTGAT
    ATGAATAGTAGACCTGATGGAACATTTATACTTGGCGCGACCATGAATGCTCGTGAGTTT
    GAGTTGGGTGAAAATCAAGAAAGTTATGTTACAAAGAATTTCACAGGGACATTAATTGGT
    AGTCATCAAGGTAAACATTATGCTATCTATAATTTGAAAAAGCCATTATTCAATACATTA
    AATAATGCTGCTATTCAGGATCTCACCTTGAAAGATGTCAATATTTCTGGTAAGAATCAT
    GTCGCATCAGTTGCTATGGAAGCCACAAATTCTTCAACTTTAGATAACGTTCACGCAAAT
    GGAATCATTGCTGGTGAACTAGGTATCGGAGGACTTGTCCAAAAAGTTGATAATTCTACA
    GTAAGAAATAGTAGCTTCACCGGAAGAATAACAAATACTTTTGTTACAACTTCTCAGTAT
    GCAATTGGTGGTCTAGTCGGTCAATTAACCGGTGCTAATGCTAGGGTAGCTCATTCTATT
    TCAACAGTAGTCATTTCAAGTAATGGAGAACATTCTAATCAAACAATTGGTGGTATTGTT
    GGTATTGTAGAAAATAATGCGACTGTAGAAAATAGTTATGCTGAAGGTGAAATAAATAAT
    GCTAAACCATTCGCTAGAGTTGGTGGAGTTGCAGGTTCCCTATGGACACAAGAAGGCGGA
    ACAGATAACAATACTGGTCGCTTGACAAATGTTCTCAGCGATATGAATATTACAAATGGG
    AATGCGATTTCTGGTTACCACTTCAATGGTATAAAGGAAACAAATGTCTATAGTAATAAA
    GAAAACAAAGTAGTCAACGTTCAAGCAGTTGGAGATGAGGTAATGTCAGTTGATTCCACT
    GTAGAACGTGGTACTGAGATTGAAAAAACATCAGTTCAAGCTAAGAAAGATGAGATTACT
    AAAAAACACACTATCACAGTGGAAGATTTCACAAATTCTGTTAAACAGGATGTAGATTAT
    ACCAAGGCAGCACATTATCAATCAACAAGAGAAGTTGCATATAAAAATATAGAAAAATTA
    TTACCTTTCTATAATAGAGATACTATTGTGAAATATGGAAATCAATTATCTACTGATCAT
    AACCTGTTTAAGAAAGAATTGTTGTCTGTTGTAGCTATGAAAAATGATGAAGTAGTCTCA
    GATATCACTTCAAACAAGAACTCTATCAATCACTTACTACTACATTACAAAGACGGAACA
    TCTGAGAAAGTAGATTTAACCTACAATAGTGACTTTGCAAATCTGGCTGAGTATAATATT
    GAAAATACTGGTCTAGTATACACACCAAATGCTTTCCTAAAAAATTATACGCCTATAATA
    GACAGAGTTAAAAATGATTTAACTGCAGTACCGTATAATCCAACTGCTCTTAAGAATTTG
    TTAGGAATCTCTGATAATGTTAAATTAACAGAACTTTATCTAGATGAGCAATTCACTAAG
    ACCAAAGAGCACTTAACTGAAACTCTTAAAAAATTACTTTCAGCTGATGCTGCTGTTTCT
    GGAAATAATGATATAATTGACAATTACATTGTTGATAAAATCAAGCGAAACAAAGAAGCC
    TTGATGCTAGGATTAACCTATCTAGAACGCTGGTATGATTTCAAATTCGATAAGGCTAGC
    GCAAAAGATTTGCTTATGTTCCATATGGATTTCTTTGGTAAGGGAAATACCTCTCCGCTA
    GATGCAATTATCGAATTAGGTAAATCTGGCTACAACAATCTCTTGGCCAAAAATAATGTG
    GTTACTTACAATGCCTTGTTAACGAATAACTACGGTACAAAAGATCTGTTTAGTGCTTTA
    GAAGGCTACCGTAAAGCATTTGCACCGCATCAAACTAACAATGAATGGTTTAAATCACAG
    ACTAAGGCTTACATTGTCGAAGAAAAATCCAATATCGAAGAGGTGAAAACGAAGCAAGGA
    CTAGTTGGCACTAAGTATTCTATTGGTGTCTATGACCGTATCACTAGTGCCACATGGAAA
    TACCGCAATATGGTCTTGCCGCTCCTAACCTTGCCGGAGAAATCAGTCTTTGTCATCTCG
    ACCATCTCTAGTCTAGGATTTGGAGCTTATGATCGTTACCGCAATAGTGAGCACAAAGCA
    GGCAAGGACCTCAATGATTTTGTTGAAGAAAATGCACGTGAAACAGCCAAACATCAGCGA
    GATCACTACGATTATTGGTATCGTATTTTAGACGACAATGCACGTGAAAAACTTTATAGA
    AATATTTTGCTTTACGATGCTTATAAATTTGGCGATGATAATACCGTAGGGAAAGCTACA
    GAAGTGGCAGATTTTGATAATCCAAATCCTGCAATGCAACATTTCTTTGGACCTGTTGGA
    AATAAAGTTGGGCATAATCAACACGGTGCTTATGCTACAGGTGATGCAGTTTATTATATG
    GGTTATCGAATGTTGGATAAGGATGGAGCTATTACTTATACGCATGAGATGACACATGAC
    TCAGATCAGGACATTTATCTTGGAGGATATGGTCGAAGAAGTGGCTTGGGACCAGAGTTC
    TTTGCTAAAGGATTATTACAAGCACCAGACCATCCAGATGATGCGACCATTACCATCAAC
    TCCATCTTGAAACATTCGAAATCTGATAGTACAGAAAGTCGACGATTACAAGTACTTGAT
    CCAACTACAAGATTTAATAATGCAGATGATTTGAAGCAATATGTCCACAACATGTTTGAC
    GTTGTTTATATGTTGGAATATCTCGAAGGAAATTCAATTCTTAAATTGGATACGAATCAA
    AAACAACAACTTCTTAGAAAAGTTACAAATGAGTACCATCCTGATCCTGATGGAAATAAG
    GTCTATGCAACAAATGTTGTCAGAAATATAACAGTAGAAGAAGTTGAAAGACTACGTTCA
    TTCAATGATTTGATTGATAATAATATTCTTTCGTCTAGGGAATATGCCTCAGGTAAATAC
    GAAAGAAATGGCTATTTCACTATTAAATTATTTGCGCCGATTTATGCAGCATTAAGTAAT
    GATGACGGAACGCCAGGTGATCTGATGGGACGTCGTATGGCCTATGAACTATTAGCTGCA
    AAAGGCTTTAAAGATGGTATGGTGCCATATATCTCAAATCAATTTGAAGCAGATGCTAGG
    GCAAATAATAAAACGATTACCTCATATGGTAAGACCAAAGGATTAGTAACAGATACATTA
    GTTCTTCAAAGATTATTTAATGGACAATACAATACCTGGAGTGATTTTAAGAAAGCTATG
    TATAAAGAACGTCAGGATAAATTCAATAAATTGAACAAAATTTCATTTAAAGATCCGTCT
    CAACCTTGGACGCGCAATATTATTAAGACAATTCACAGTGTAAATGAACTGCAGAACTTA
    ATGAATGAAGCTGTCCGCAAGGATACAGAAACTCCTCATTGGTATAACTATAATCCAGAA
    ATAGACAGTGCAGTTCATAAGTTGAAGAGAGCAATCTTTAAAGCCTATCTTGACCAAACA
    AATGATTTTAGAAGTTCAATTTTTGAGAATAAAAAATAG
    60
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    2160
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    3420
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    4140
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    5040
    5100
    5160
    5220
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    5340
    5400
    5460
    5520
    5580
    5640
    5679

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU17_RS05385 [old locus tag: SPNHU17_01164 ]
  • symbol: SPNHU17_RS05385
  • description: ZmpA/ZmpB/ZmpC family metallo-endopeptidase
  • length: 1892
  • theoretical pI: 5.35995
  • theoretical MW: 211431
  • GRAVY: -0.558932

⊟Function[edit | edit source]

  • TIGRFAM:
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 44.6)
    and 1 more
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 21.4)
  • TheSEED: data available for Hungary19A-6
  • PFAM:
    no clan defined Peptidase_M26_C; M26 IgA1-specific Metallo-endopeptidase C-terminal region (PF07580; HMM-score: 963.1)
    and 6 more
    Peptidase_M26_N; M26 IgA1-specific Metallo-endopeptidase N-terminal region (PF05342; HMM-score: 261.9)
    G5 (CL0593) G5; G5 domain (PF07501; HMM-score: 50.9)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 36.1)
    Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 29.6)
    Glug; The GLUG motif (PF07581; HMM-score: 26)
    DUF6015; Family of unknown function (DUF6015) (PF19479; HMM-score: 9.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 2
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0002
    • Cytoplasmic Membrane Score: 0.0043
    • Cell wall & surface Score: 0.8379
    • Extracellular Score: 0.1576
  • SignalP: Signal peptide SP(Sec/SPI) length 42 aa
    • SP(Sec/SPI): 0.91723
    • TAT(Tat/SPI): 0.067255
    • LIPO(Sec/SPII): 0.005174
    • Cleavage Site: CS pos: 42-43. VDA-QE. Pr: 0.9143
  • predicted transmembrane helices (TMHMM): 3

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000417124 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQETAGVHYKYVADSELSSEEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSKNERQALVAGASLAALGILIFAVSKKKVKNKTVLHLVLVAGIGNGVLVSVHALENHLLLNYNTDYELTSGEKLPLPKEISGYTYIGYIKEGKTTSDFEVSNQEKSAATPTKQQKVDYNVTPNFVDHPSTVQAIQEQTPVSSTKPTEVQVVEKPFSTELINPRKEEKQSSDSQEQLAEHKNLETKKEEKISPKEKTGVNTLNPQDEVLSGQLNKPELLYREETIEIKIDFQEEIQENPDLVEGIVRVKQEGKLGKKVEIVRIFSVNKEEVSREIVSTSTTAPIPRIVEKGTKKTQVIKEQPETGVEHKDVQSGAIVEPAIQPELPEAVVSDKGVPEVQPALSKAVITDKGETEVQPESPDTVVSDKGEPAVQPESPDTVVSDKGEPKQVAPLPEYTGPQASAIVEPEQVAPLPEYTGVQAGAIVEPAVQPALPEAVVSDKGVPEVQPELPEAVVSDKGVPEVQPELPEAVVSDKGEPEQVAPLPEYKGNIEQVKPETPVEKLQEEEPEKTIELRSVSDVELYSYEANQSKQHTILDKVPDNKSAYFIKVKSAKFKDVLLPVSNIEDTTKDGKVVYKITARLEHLKQSVDNQYQDNFTYYLPKVVQNDGPIYTSFKKLVTDMNSRPDGTFILGATMNAREFELGENQESYVTKNFTGTLIGSHQGKHYAIYNLKKPLFNTLNNAAIQDLTLKDVNISGKNHVASVAMEATNSSTLDNVHANGIIAGELGIGGLVQKVDNSTVRNSSFTGRITNTFVTTSQYAIGGLVGQLTGANARVAHSISTVVISSNGEHSNQTIGGIVGIVENNATVENSYAEGEINNAKPFARVGGVAGSLWTQEGGTDNNTGRLTNVLSDMNITNGNAISGYHFNGIKETNVYSNKENKVVNVQAVGDEVMSVDSTVERGTEIEKTSVQAKKDEITKKHTITVEDFTNSVKQDVDYTKAAHYQSTREVAYKNIEKLLPFYNRDTIVKYGNQLSTDHNLFKKELLSVVAMKNDEVVSDITSNKNSINHLLLHYKDGTSEKVDLTYNSDFANLAEYNIENTGLVYTPNAFLKNYTPIIDRVKNDLTAVPYNPTALKNLLGISDNVKLTELYLDEQFTKTKEHLTETLKKLLSADAAVSGNNDIIDNYIVDKIKRNKEALMLGLTYLERWYDFKFDKASAKDLLMFHMDFFGKGNTSPLDAIIELGKSGYNNLLAKNNVVTYNALLTNNYGTKDLFSALEGYRKAFAPHQTNNEWFKSQTKAYIVEEKSNIEEVKTKQGLVGTKYSIGVYDRITSATWKYRNMVLPLLTLPEKSVFVISTISSLGFGAYDRYRNSEHKAGKDLNDFVEENARETAKHQRDHYDYWYRILDDNAREKLYRNILLYDAYKFGDDNTVGKATEVADFDNPNPAMQHFFGPVGNKVGHNQHGAYATGDAVYYMGYRMLDKDGAITYTHEMTHDSDQDIYLGGYGRRSGLGPEFFAKGLLQAPDHPDDATITINSILKHSKSDSTESRRLQVLDPTTRFNNADDLKQYVHNMFDVVYMLEYLEGNSILKLDTNQKQQLLRKVTNEYHPDPDGNKVYATNVVRNITVEEVERLRSFNDLIDNNILSSREYASGKYERNGYFTIKLFAPIYAALSNDDGTPGDLMGRRMAYELLAAKGFKDGMVPYISNQFEADARANNKTITSYGKTKGLVTDTLVLQRLFNGQYNTWSDFKKAMYKERQDKFNKLNKISFKDPSQPWTRNIIKTIHSVNELQNLMNEAVRKDTETPHWYNYNPEIDSAVHKLKRAIFKAYLDQTNDFRSSIFENKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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