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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 22-FEB-2023

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_RS05230 [old locus tag: SPAP_1059 ]
  • pan locus tag?: PNEUPAN002294000
  • symbol: SPAP_RS05230
  • pan gene symbol?: zmpA
  • synonym: iga
  • product: ZmpA/ZmpB/ZmpC family metallo-endopeptidase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_RS05230 [old locus tag: SPAP_1059 ]
  • symbol: SPAP_RS05230
  • product: ZmpA/ZmpB/ZmpC family metallo-endopeptidase
  • replicon: chromosome
  • strand: -
  • coordinates: 999021..1004648
  • length: 5628
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014494 (999021..1004648) NCBI
  • BioCyc: SPAP_RS05230 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1018 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
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    3481
    3541
    3601
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    3781
    3841
    3901
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    4141
    4201
    4261
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    4441
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    4741
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    4981
    5041
    5101
    5161
    5221
    5281
    5341
    5401
    5461
    5521
    5581
    ATGGAAAAGTATTTTGGTGAAAAACAAGAGCGTTTTTCATTTAGAAAATTATCAGTAGGA
    CTTGTATCTGCAACGATTTCAAGTTTATTTTTTATGTCTGTATTAGCTAGTTCATCTGTG
    GATGCTCAAGAAACTGCGGGAGTTCACTATAAATATGTGGCAGATTCAGAGCTATCATCA
    GAAGAAAAGAAGCAGCTTGTCTATGATATTCCGACATACGTGGAGAATGATGATGAAACT
    TATTATCTTGTTTATAAGTTAAATTCTCAAAATCAACTGGCGGAATTACCAAATACTGGA
    AGCAAGAATGAGAGGCAAGCCCTAGTTGCTGGTGCTAGCTTAGCTGCTCTGGGAATTTTA
    ATTTTTGCTGTTTCCAAGAAAAAGGTTAAGAATAAAACGGTATTACATTTAGTATTGGTT
    GCGGGAATGGGAAATGGTGTCTTAGTTTCAGTCCATGCTTTAGAAAATCATCTTTTGCTA
    AATTACAATACGGACTATGAATTGACCTCTGGAGAAAAATTACCTCTTCCTAAAGAGATT
    TCAGGTTACACTTATATTGGATATATCAAAGAGGGAAAAACGACTTCTGATTTTGAAGTA
    AGTAATCAAGAAAAATCAGCAGCCACTCCTACAAAACAACAAAAGGTGGATTATAATGTT
    ACACCAAATTTTGTAGACCATCCATCAACAGTACAAGCTATTCAGGAACAAACACCTGTT
    TCTTCAACTAAGCCGACAGAAGTTCAAGTAGTTGAAAAACCTTTCTCTACTGAATTAATC
    AATCCAAGAAAAGAAGAGAAACAATCTTCAGATTCTCAAGAACAATTAGCCGAACATAAG
    AATCTAGAAACGAAGAAAGAGGAGAAGATTTCTCCAAAAGAAAAGACTGGGGTAAATACA
    TTAAATCCACAGGATGAAGTTTTATCAGGTCAATTGAACAAACCTGAACTCTTATATCGT
    GAGGAAACTATAGAGACAAAAATAGATTTTCAAGAAGAAATTCAAGAAAATCCTGATTTA
    GCTGAAGGAACTGTAAGAGTAAAACAAGAAGGTAAATTAGGTAAGAAAGTTGAAATCGTC
    AGAATATTCTCTGTAAACAAGGAAGAAGTTTCGCGAGAAATTGTTTCAACTTCAACGACT
    GCGCCTAGTCCAAGAATAGTCGAAAAAGGTACTAAAAAAACTCAAGTTATAAAGGAACAA
    CCTGAGACTGGTGTAGAACATAAGGACGTACAGTCTGGAGCTATTGTTGAACCCGCAATT
    CAGCCTGAGTTGCCCGAAGCTGTAGTAAGTGATAAAGGTGAACCAGCAGTCCAACCAGAG
    CTACCGGAAGCGGTTGTGACTGACAAAGGTGAGACTGAGGTTCAACCAGAGTCGCCAGAT
    ACTGTGGTAAGTGATAAAGGTGAACCTAAACAGGTAGCACCGCTTCCAGAATATACAGGA
    CCACAAGCCAGCGCTATTGTTGAACCAGAGCAGGTAGCACCACTACCAGAATACACAGGG
    GTACAAGCCGGAGCTATTGTTGAACCCGCAGTCCAGCCAGCGTTACCCGAAGCAGTTGTA
    AGCGATAAAGGCGTACCAGAAGTTCAGCCTGAGTTGCCCGAAGCAGTAGTAAGTGATAAA
    GGCGTACCAGAAGTTCAGCCTGAATTACCCGAAGCAGTTGTAAGTGATAAAGGTGAACCA
    GAGCAGGTAGCACCATTGCCAGAATATAAGGGGAATATTGAGCAAGTAAAACCTGAAACT
    CCGGTTGAGAAACTTCAAGAGGAAGAACCAGAGAAAACAATAGAACTAAGAAGTGTTTCT
    GATGTGGAACTCTATAGTTATGAAGCTAATCAATCAAAACAACATACAATCTTAGATAAA
    GTACCAGATAATAAATCTGCTTATTTCATCAAAGTGAAGTCAGCTAAATTTAAAGATGTA
    CTGCTCCCAGTTTCAAACATTGAGGACACTACAAAAGACGGTAAAGTAGTCTATAAAATT
    ACAGCTAGATTGGAACACTTAAAACAATCTGTAGACAATCAATACCAAGATAATTTTACT
    TATTATCTTCCAAAAGTTGTTCAAAACGATGGCCCTATCTACACATCATTTAAAAAATTA
    GTAACTGATATGAATAGTAGACCTGATGGAACATTTATACTTGGCGCGACCATGAATGCT
    CGTGAGTTTGAGTTGGGTGAAAATCAAGAAAGTTATGTTACAAAGAATTTCACAGGGACA
    TTAATTGGTAGTCATCAAGGTAAACATTATGCTATCTATAATTTGAAAAAGCCATTATTC
    AATACATTAAATAATGCTGCTATTCAGGATCTCACCTTGAAAGATGTCAATATTTCTGGT
    AAGAATCATGTCGCATCAGTTGCTATGGAAGCCACAAATTCTTCAACTTTAGATAACGTT
    CACGCAAATGGAATCATTGCTGGTGAACTAGGTATCGGAGGACTTGTCCAAAAAGTTGAT
    AATTCTACAGTAAGAAATAGTAGCTTCACCGGAAGAATAACAAATACTTTTGTTACAACT
    TCTCAGTATGCAATTGGTGGTCTAGTCGGTCAATTAACCGGTGCTAATGCTAGGGTAGCT
    CATTCTATTTCAACAGTAGTCATTTCAAGTAATGGAGAACATTCTAATCAAACAATTGGT
    GGTATTGTTGGTATTGTAGAAAATAATGCGACTGTAGAAAATAGTTATGCTGAAGGTGAA
    ATAAATAATGCTAAACCATTCGCTAGAGTTGGTGGAGTTGCAGGTTCCCTATGGACACAA
    GAAGGCGGAACAGATAACAATACTGGTCGCTTGACAAATGTTCTCAGCGATATGAATATT
    ACAAATGGGAATGCGATTTCTGGTTACCACTTCAATGGTATAAAGGAAACAAATGTCTAT
    AGTAATAAAGAAAACAAAGTAGTCAATGTTCAAGCAGTTGGAGATGAGGTAATGTCAGTT
    GATTCCACTGTAGAACGTGGTACTGAGATTGAAAAAACATCAGTTCAAGCTAAGAAAGAT
    GAGATTACTAAAAAACACACTATCACAGTGGAAGATTTCACAAATTCTGTTAAACAGGAT
    GTAGATTATACCAAGGCAGCACATTATCAATCAACAAGAGAAGTTGCATATAAAAATATA
    GAAAAATTATTACCTTTCTATAATAGAGATACTATTGTGAAATATGGAAATCAATTATCT
    ACTGATCATAACCTGTTTAAGAAAGAATTGTTGTCTGTTGTAGCTATGAAAAATGATGAA
    GTAGTCTCAGATATCACTTCAAACAAGAACTCTATCAATCACTTACTACTACATTACAAA
    GACGGAACATCTGAGAAAGTAGATTTAACCTACAATAGTGACTTTGCAAATCTGGCTGAG
    TATAATATTGAAAATACTGGTCTAGTATACACACCAAATGCTTTCCTAAAAAATTATACG
    CCTATAATAGACAGAGTTAAAAATGATTTAACTGCAGTACCGTATAATCCAACTGCTCTT
    AAGAATTTGTTAGGAATCTCTGATAATGTTAAATTAACAGAACTTTATCTAGATGAGCAA
    TTCACTAAGACCAAAGAGCACTTAACTGAAACTCTTAAAAAATTACTTTCAGCTGATGCT
    GCTGTTTCTGGAAATAATGATATAATTGACAATTACATTGTTGATAAAATCAAGCGAAAC
    AAAGAAGCCTTGATGCTAGGATTAACCTATCTAGAACGCTGGTATGATTTCAAATTCGAT
    AAGGCTAGCGCAAAAGATTTGCTTATGTTCCATATGGATTTCTTTGGTAAGGGAAATACC
    TCTCCGCTAGATGCAATTATCGAATTAGGTAAATCTGGCTACAACAATCTCTTGGCCAAA
    AATAATGTGGTTACTTACAATGCCTTGTTAACGAATAACTACGGTACAAAAGATCTGTTT
    AGTGCTTTAGAAGGCTACCGTAAAGCATTTGCACCGCATCAAACTAACAATGAATGGTTT
    AAATCACAGACTAAGGCTTACATTGTCGAAGAAAAATCCAATATCGAAGAGGTGAAAACG
    AAGCAAGGACTAGTTGGCACTAAGTATTCTATTGGTGTCTATGACCGTATCACTAGTGCC
    ACATGGAAATACCGCAATATGGTCTTGCCGCTCCTAACCTTGCCGGAGAAATCAGTCTTT
    GTCATCTCGACCATCTCTAGTCTAGGATTTGGAGCTTATGATCGTTACCGCAATAGTGAG
    CACAAAGCAGGCAAGGACCTCAATGATTTTGTTGAAGAAAATGCACGTGAAACAGCCAAA
    CGTCAGCGAGATCACTACGATTATTGGTATCGTATTTTAGACGACAATGCACGTGAAAAA
    CTTTATAGAAATATTTTGCTTTACGATGCTTATAAATTTGGCGATGATAATACCGTAGGG
    AAAGCTACAGAAGTGGCAGATTTTGATAATCCAAATCCTGCAATGCAACATTTCTTTGGA
    CCTGTTGGAAATAAAGTTGGGCATAATCAACACGGTGCTTATGCTACAGGTGATGCAGTT
    TATTATATGGGTTATCGAATGTTGGATAAGGATGGAGCTATTACTTATACGCATGAGATG
    ACACATGACTCAGATCAGGACATTTATCTTGGAGGATATGGTCGAAGAAGTGGCTTGGGA
    CCAGAGTTCTTTGCTAAAGGATTATTACAAGCACCAGACCATCCAGATGATGCGACCATT
    ACCATCAACTCCATCTTGAAACATTCGAAATCTGATAGTACAGAAAGTCGACGATTACAA
    GTACTTGATCCAACTACAAGATTTAATAATGCAGATGATTTGAAGCAATATGTCCACAAC
    ATGTTTGACGTTGTTTATATGTTGGAATATCTCGAAGGAAATTCAATTCTTAAATTGGAT
    ACGAATCAAAAACAACAACTTCTTAGAAAAGTTACAAATGAGTACCATCCTGATCCTGAT
    GGAAATAAGGTCTATGCAACAAATGTTGTCAGAAATATAACAGTAGAAGAAGTTGAAAGA
    CTACGTTCATTCAATGATTTGATTGATAATAATATTCTTTCGTCTAGGGAATATGCCTCA
    GGTAAATACGAAAGAAATGGCTATTTCACTATTAAATTATTTGCGCCGATTTATGCAGCA
    TTAAGTAATGATGACGGAACGCCAGGTGATCTGATGGGACGTCGTATGGCCTATGAACTA
    TTAGCTGCAAAAGGCTTTAAAGATGGTATGGTGCCATATATCTCAAATCAATTTGAAGCA
    GATGCTAGGGCAAATAATAAAACGATTACCTCATATGGTAAGACCAAAGGATTAGTAACA
    GATACATTAGTTCTTCAAAAATTATTTAATGGACAATACAATACCTGGAGTGATTTTAAG
    AAAGCTATGTATAAAGAACGTCAGGATAAATTCAATAAATTGAACAAAATTTCATTTAAA
    GATCCGTCTCAACCTTGGACGCGCAATATTATTAAGACAATTCACAGTGTAAATGAACTG
    CAGAACTTAATGAATGAAGCTGTCCGCAAGGATACAGAAACTCCTCATTGGTATAACTAT
    AATCCAGAAATAGACAGTGCAGTTCATAAGTTGAAGAGAGCAATCTTTAAAGCCTATCTT
    GACCAAACAAATGATTTTAGAAGTTCAATTTTTGAGAATAAAAAATAG
    60
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    5520
    5580
    5628

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_RS05230 [old locus tag: SPAP_1059 ]
  • symbol: SPAP_RS05230
  • description: ZmpA/ZmpB/ZmpC family metallo-endopeptidase
  • length: 1875
  • theoretical pI: 5.35995
  • theoretical MW: 209652
  • GRAVY: -0.57216

⊟Function[edit | edit source]

  • TIGRFAM:
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 44.6)
    and 1 more
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 21.4)
  • TheSEED: see SPAP_1059
  • PFAM:
    no clan defined Peptidase_M26_C; M26 IgA1-specific Metallo-endopeptidase C-terminal region (PF07580; HMM-score: 966.4)
    and 5 more
    Peptidase_M26_N; M26 IgA1-specific Metallo-endopeptidase N-terminal region (PF05342; HMM-score: 262.2)
    G5 (CL0593) G5; G5 domain (PF07501; HMM-score: 55.2)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 36.1)
    Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 29.6)
    Glug; The GLUG motif (PF07581; HMM-score: 26.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 2
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0002
    • Cytoplasmic Membrane Score: 0.0047
    • Cell wall & surface Score: 0.8469
    • Extracellular Score: 0.1483
  • SignalP: Signal peptide SP(Sec/SPI) length 42 aa
    • SP(Sec/SPI): 0.91723
    • TAT(Tat/SPI): 0.067255
    • LIPO(Sec/SPII): 0.005174
    • Cleavage Site: CS pos: 42-43. VDA-QE. Pr: 0.9143
  • predicted transmembrane helices (TMHMM): 3

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000417170 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQETAGVHYKYVADSELSSEEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSKNERQALVAGASLAALGILIFAVSKKKVKNKTVLHLVLVAGMGNGVLVSVHALENHLLLNYNTDYELTSGEKLPLPKEISGYTYIGYIKEGKTTSDFEVSNQEKSAATPTKQQKVDYNVTPNFVDHPSTVQAIQEQTPVSSTKPTEVQVVEKPFSTELINPRKEEKQSSDSQEQLAEHKNLETKKEEKISPKEKTGVNTLNPQDEVLSGQLNKPELLYREETIETKIDFQEEIQENPDLAEGTVRVKQEGKLGKKVEIVRIFSVNKEEVSREIVSTSTTAPSPRIVEKGTKKTQVIKEQPETGVEHKDVQSGAIVEPAIQPELPEAVVSDKGEPAVQPELPEAVVTDKGETEVQPESPDTVVSDKGEPKQVAPLPEYTGPQASAIVEPEQVAPLPEYTGVQAGAIVEPAVQPALPEAVVSDKGVPEVQPELPEAVVSDKGVPEVQPELPEAVVSDKGEPEQVAPLPEYKGNIEQVKPETPVEKLQEEEPEKTIELRSVSDVELYSYEANQSKQHTILDKVPDNKSAYFIKVKSAKFKDVLLPVSNIEDTTKDGKVVYKITARLEHLKQSVDNQYQDNFTYYLPKVVQNDGPIYTSFKKLVTDMNSRPDGTFILGATMNAREFELGENQESYVTKNFTGTLIGSHQGKHYAIYNLKKPLFNTLNNAAIQDLTLKDVNISGKNHVASVAMEATNSSTLDNVHANGIIAGELGIGGLVQKVDNSTVRNSSFTGRITNTFVTTSQYAIGGLVGQLTGANARVAHSISTVVISSNGEHSNQTIGGIVGIVENNATVENSYAEGEINNAKPFARVGGVAGSLWTQEGGTDNNTGRLTNVLSDMNITNGNAISGYHFNGIKETNVYSNKENKVVNVQAVGDEVMSVDSTVERGTEIEKTSVQAKKDEITKKHTITVEDFTNSVKQDVDYTKAAHYQSTREVAYKNIEKLLPFYNRDTIVKYGNQLSTDHNLFKKELLSVVAMKNDEVVSDITSNKNSINHLLLHYKDGTSEKVDLTYNSDFANLAEYNIENTGLVYTPNAFLKNYTPIIDRVKNDLTAVPYNPTALKNLLGISDNVKLTELYLDEQFTKTKEHLTETLKKLLSADAAVSGNNDIIDNYIVDKIKRNKEALMLGLTYLERWYDFKFDKASAKDLLMFHMDFFGKGNTSPLDAIIELGKSGYNNLLAKNNVVTYNALLTNNYGTKDLFSALEGYRKAFAPHQTNNEWFKSQTKAYIVEEKSNIEEVKTKQGLVGTKYSIGVYDRITSATWKYRNMVLPLLTLPEKSVFVISTISSLGFGAYDRYRNSEHKAGKDLNDFVEENARETAKRQRDHYDYWYRILDDNAREKLYRNILLYDAYKFGDDNTVGKATEVADFDNPNPAMQHFFGPVGNKVGHNQHGAYATGDAVYYMGYRMLDKDGAITYTHEMTHDSDQDIYLGGYGRRSGLGPEFFAKGLLQAPDHPDDATITINSILKHSKSDSTESRRLQVLDPTTRFNNADDLKQYVHNMFDVVYMLEYLEGNSILKLDTNQKQQLLRKVTNEYHPDPDGNKVYATNVVRNITVEEVERLRSFNDLIDNNILSSREYASGKYERNGYFTIKLFAPIYAALSNDDGTPGDLMGRRMAYELLAAKGFKDGMVPYISNQFEADARANNKTITSYGKTKGLVTDTLVLQKLFNGQYNTWSDFKKAMYKERQDKFNKLNKISFKDPSQPWTRNIIKTIHSVNELQNLMNEAVRKDTETPHWYNYNPEIDSAVHKLKRAIFKAYLDQTNDFRSSIFENKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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