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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_2236 [new locus tag: SP70585_RS11110 ]
  • pan locus tag?: PNEUPAN003695000
  • symbol: SP70585_2236
  • pan gene symbol?: —
  • synonym:
  • product: D-mannonate oxidoreductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_2236 [new locus tag: SP70585_RS11110 ]
  • symbol: SP70585_2236
  • product: D-mannonate oxidoreductase
  • replicon: chromosome
  • strand: -
  • coordinates: 2045699..2046538
  • length: 840
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGACACGTGTTATTGAATTTAAAGACAAGGTTGTTGTTATTACCGGAGCTGGAGGCGTT
    CTTTGTGGTTATTTGGCAAAAGAATTTGCGAAGGCTGGTGCTAAAGTAGCTCTTTTGGAC
    TTAAATGAGGTAGCTGCTCAAGTGTTTGTTGATGAAATTGAGTCAGTAGGTGGAGTTGCA
    AAGACCTATAAATCTAACGTTCTTTCTAAGGAAAATTTGGAAGAAGTTCGCCAACAAGTC
    TTAGCAGATTTTGGTCCAGTTGATATCTTGGTTAACGGTGCCGGAGGCAACAATCCGAAA
    GCAACGACGGACAATGAGTTTCATGAAATTGGACTTCCTGTGGACACCAAAACTTTCTTT
    GATTTGGACGAGGCGGGAATCAACTTTGTATTCAATTTGAATTATTTAGGTACTCTCTTG
    CCAACTCAGGTATTTGCGCAGGATATGATTGGCCGTAGCGGAGCAAATATTATTAATATT
    TCTAGCATGAACGCCTTCACACCATTGACTAAAATTCCAGCATATTCAGGGGCCAAAGCT
    GCCATCAGCAATTTTACTCAGTGGTTAGCAGTGCATTTTTCAAAAGTTGGAATCCGTTGC
    AATGCCATTGCACCAGGTTTCTTTTTAACCAATCAGAACCGCGGCTTGTTATTTGATGAG
    TCAGGTCAACCGACAGCACGTGCCAACAAGATTTTGACCAATACACCGATGGGACGGTTT
    GGCGAAGCAGAAGAGCTAGTTGGAGGTGTCTTCTTCTTAGCAGATGAGAATCTGGCAAGT
    TTTGTAAATGGCGTTGTTTTACCGATTGACGGTGGATTTTCAGCCTATTCAGGAGTCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP70585_2236 [new locus tag: SP70585_RS11110 ]
  • symbol: SP70585_2236
  • description: D-mannonate oxidoreductase
  • length: 279
  • theoretical pI: 4.60651
  • theoretical MW: 29739.7
  • GRAVY: 0.186022

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides 2-deoxy-D-gluconate 3-dehydrogenase (TIGR01832; EC 1.1.1.125; HMM-score: 132.5)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase (TIGR01830; EC 1.1.1.100; HMM-score: 122.9)
    2-hydroxycyclohexanecarboxyl-CoA dehydrogenase (TIGR03206; EC 1.1.1.-; HMM-score: 109.1)
    and 11 more
    2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (TIGR04316; EC 1.3.1.28; HMM-score: 101.5)
    Metabolism Energy metabolism Fermentation acetoin reductases (TIGR02415; EC 1.1.1.-; HMM-score: 99.2)
    3-hydroxybutyrate dehydrogenase (TIGR01963; HMM-score: 98.1)
    acetoacetyl-CoA reductase (TIGR01829; EC 1.1.1.36; HMM-score: 97.1)
    Unknown function Enzymes of unknown specificity SDR family mycofactocin-dependent oxidoreductase (TIGR03971; EC 1.1.99.-; HMM-score: 87.6)
    rhamnulose-1-phosphate aldolase/alcohol dehydrogenase (TIGR02632; EC 1.1.1.1,4.1.2.19; HMM-score: 61.9)
    cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (TIGR03325; EC 1.3.1.56; HMM-score: 58.7)
    Unknown function Enzymes of unknown specificity SDR family mycofactocin-dependent oxidoreductase (TIGR04504; EC 1.1.99.-; HMM-score: 53.4)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis putative 3-oxoacyl-(acyl-carrier-protein) reductase (TIGR01831; HMM-score: 47.9)
    pteridine reductase (TIGR02685; EC 1.5.1.33; HMM-score: 42.2)
    sepiapterin reductase (TIGR01500; EC 1.1.1.153; HMM-score: 17.2)
  • TheSEED  :
    • D-mannonate oxidoreductase (EC 1.1.1.57)
    Carbohydrates Central carbohydrate metabolism Entner-Doudoroff Pathway  D-mannonate oxidoreductase (EC 1.1.1.57)
    and 1 more
    Carbohydrates Monosaccharides D-Galacturonate and D-Glucuronate Utilization  D-mannonate oxidoreductase (EC 1.1.1.57)
  • PFAM:
    NADP_Rossmann (CL0063) adh_short; short chain dehydrogenase (PF00106; HMM-score: 138.6)
    adh_short_C2; Enoyl-(Acyl carrier protein) reductase (PF13561; HMM-score: 137.8)
    and 2 more
    KR; KR domain (PF08659; HMM-score: 19.4)
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 17)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.180853
    • TAT(Tat/SPI): 0.034598
    • LIPO(Sec/SPII): 0.012882
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTRVIEFKDKVVVITGAGGVLCGYLAKEFAKAGAKVALLDLNEVAAQVFVDEIESVGGVAKTYKSNVLSKENLEEVRQQVLADFGPVDILVNGAGGNNPKATTDNEFHEIGLPVDTKTFFDLDEAGINFVFNLNYLGTLLPTQVFAQDMIGRSGANIINISSMNAFTPLTKIPAYSGAKAAISNFTQWLAVHFSKVGIRCNAIAPGFFLTNQNRGLLFDESGQPTARANKILTNTPMGRFGEAEELVGGVFFLADENLASFVNGVVLPIDGGFSAYSGV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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