From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_0664 [new locus tag: SPD_RS03570 ]
  • pan locus tag?: PNEUPAN001702000
  • symbol: metK
  • pan gene symbol?: metK
  • synonym:
  • product: S-adenosylmethionine synthetase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_0664 [new locus tag: SPD_RS03570 ]
  • symbol: metK
  • product: S-adenosylmethionine synthetase
  • replicon: chromosome
  • strand: +
  • coordinates: 683651..684841
  • length: 1191
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGTCAGAACGTAAATTATTCACGTCTGAATCTGTATCTGAGGGGCATCCGGATAAGATT
    GCAGACCAAATTTCAGATGCGATTTTGGATGCTATTTTAGCAAAGGATCCAGAGGCGCAC
    GTTGCTGCTGAAACAGCTGTATATACTGGTTCTGTCCACGTTTTTGGTGAAATTTCTACA
    AATGCCTATGTGGATATTAACCGTGTGGTTCGTGATACCATTGCAGAGATTGGTTATACC
    AATACAGAATATGGATTTTCTGCTGAGACGGTGGGAGTACACCCATCTTTGGTGGAACAA
    TCTCCTGACATCGCTCAAGGTGTTAACGAAGCCTTGGAGGTTCGCGGAAATGCTGATCAA
    GATCCACTGGACTTGATTGGAGCAGGTGACCAAGGGCTCATGTTTGGATTTGCAGTAGAT
    GAAACAGAAGAGCTTATGCCATTGCCAATTGCACTCAGTCATAAATTGGTTCGTCGTCTG
    GCAGAACTTCGTAAGTCTGGAGAAATTAGCTATCTCCGTCCAGATGCAAAATCACAAGTT
    ACAGTTGAGTACGATGAAAATGACCGTCCGGTACGTGTAGATACAGTCGTTATTTCTACT
    CAGCATGATCCAGAGGCCACTAATGAACAAATCCATCAAGATGTGATTGACAAGGTCATC
    AAAGAAGTTATTCCATCTTCTTATCTTGATGATAAGACAAAATTCTTTATCAATCCGACA
    GGTCGTTTTGTAATCGGTGGTCCTCAAGGGGACTCAGGTTTGACTGGTCGTAAGATTATT
    GTAGATACTTATGGTGGCTACTCTCGTCATGGTGGTGGTGCCTTCTCTGGTAAAGATGCG
    ACTAAGGTGGATCGTTCAGCCTCTTATGCGGCTCGCTATATTGCCAAGAATATCGTTGCA
    GCAGGCCTTGCTAAGAAGGCAGAAGTGCAGTTGGCCTATGCTATCGGTGTTGCGCAACCT
    GTTTCTGTTCGTATCGATACTTTCGGTACAGGAACAGTAGCTGAAAGTCAACTTGAAAAA
    GCGGCTCGTCAAATCTTTGACCTTCGCCCTGCAGGGATTATCCAAATGCTGGACCTCAAG
    CGTCCAATTTACCGTCAAACATCGGCTTACGGTCACATGGGACGTACAGATATTGATCTT
    CCATGGGAACGTTTGGATAAGGTAGATGCTTTGAAAGAAGCAGTAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1191

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_0664 [new locus tag: SPD_RS03570 ]
  • symbol: MetK
  • description: S-adenosylmethionine synthetase
  • length: 396
  • theoretical pI: 4.80383
  • theoretical MW: 43115.1
  • GRAVY: -0.27601

⊟Function[edit | edit source]

  • reaction:
    EC 2.5.1.6?  ExPASy
    Methionine adenosyltransferase ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine
  • TIGRFAM:
    Metabolism Central intermediary metabolism Other methionine adenosyltransferase (TIGR01034; EC 2.5.1.6; HMM-score: 584.5)
  • TheSEED  :
    • S-adenosylmethionine synthetase (EC 2.5.1.6)
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Methionine Biosynthesis  S-adenosylmethionine synthetase (EC 2.5.1.6)
    and 2 more
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Methionine Degradation  S-adenosylmethionine synthetase (EC 2.5.1.6)
    Cofactors, Vitamins, Prosthetic Groups, Pigments Folate and pterines Folate Biosynthesis  S-adenosylmethionine synthetase (EC 2.5.1.6)
  • PFAM:
    no clan defined S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain (PF02773; HMM-score: 228.3)
    and 3 more
    S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain (PF02772; HMM-score: 174)
    S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain (PF00438; HMM-score: 136.9)
    AdoMet_Synthase; S-adenosylmethionine synthetase (AdoMet synthetase) (PF01941; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9569
    • Cytoplasmic Membrane Score: 0.0046
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.0382
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005664
    • TAT(Tat/SPI): 0.000815
    • LIPO(Sec/SPII): 0.000604
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSERKLFTSESVSEGHPDKIADQISDAILDAILAKDPEAHVAAETAVYTGSVHVFGEISTNAYVDINRVVRDTIAEIGYTNTEYGFSAETVGVHPSLVEQSPDIAQGVNEALEVRGNADQDPLDLIGAGDQGLMFGFAVDETEELMPLPIALSHKLVRRLAELRKSGEISYLRPDAKSQVTVEYDENDRPVRVDTVVISTQHDPEATNEQIHQDVIDKVIKEVIPSSYLDDKTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSGKDATKVDRSASYAARYIAKNIVAAGLAKKAEVQLAYAIGVAQPVSVRIDTFGTGTVAESQLEKAARQIFDLRPAGIIQMLDLKRPIYRQTSAYGHMGRTDIDLPWERLDKVDALKEAVK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SPD_0664&oldid=7247"