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serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_1099 [new locus tag: SPG_RS05540 ]
  • pan locus tag?: PNEUPAN002469000
  • symbol: ispA
  • pan gene symbol?: ispA
  • synonym:
  • product: geranyltranstransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_1099 [new locus tag: SPG_RS05540 ]
  • symbol: ispA
  • product: geranyltranstransferase
  • replicon: chromosome
  • strand: -
  • coordinates: 1075678..1076553
  • length: 876
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGAAAAAGCAAGAAAAATTAGCTCTTGTCGAGTCGGCTTTGGAAGATTTTTATGGAGAC
    CAGCAGTTTGCCTCTAGTTTACGGGAGTCTGTTCTCTATTCTATTCATGCTGGTGGCAAG
    CGTATTCGGCCTTTTCTCTTGTTAGAAGTTCTGGAAGCCTTGCAGGTTACCATCAAACCT
    GCTCACGCGCAGGTAGCTACTGCCTTGGAGATGATTCATACAGGGAGCTTGATTCACGAT
    GACCTTCCTGCTATGGATGATGACGATTATCGAAGAGGGCGGTTAACCAATCACAAGAAA
    TTCGGTGAAGCTATGGCCATTTTGGCTGGAGATGCCTTATTCTTAGACTCATATGCCTTG
    ATTGCGCAGGCAGATTTGCCAAGTCAGATTAAGGTGGACTTGATTGCCAACTTATCCCTT
    GCTTCAGGTAGTCTGGGTATGGTGGCAGGGCAAGTTTTGGATATGGAGGGCGAACACCAG
    CANTTGTCTTTGGAAGAACTTCAGACTATTCATGCCAATAAGACTGGGAAGTTACTAGCC
    TATCCCTTCCAAGCGGCAGCTATTATAGCTGAATTGTCACCTGAAATGCAGGTGAAGCTG
    AAAACTGTGGGTGAATTGATTGGACTTGCTTTTCAAGTTAGAGATGATGTACTGGATGTG
    ACAGCTAGTTTTGAGGAAATCGGCAAGACACCTCAAAAGGATCTGCAGGCAGAAAAATCA
    ACCTATCCTGCCCTGTTGGGCTTGGAAGAGTCCATTGCCTTTTGTAACCAAACCCTGGAT
    CAAGCTAATGAAAAATTAGAAGAAATTGCCCAGCAGATTCCCTTTGAAACAGAATCGATT
    GTAAGTGTAGTAGAAAGTTTGAGAATCAATGGCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    876

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_1099 [new locus tag: SPG_RS05540 ]
  • symbol: IspA
  • description: geranyltranstransferase
  • length: 291
  • theoretical pI: 4.40403
  • theoretical MW: 31731
  • GRAVY: -0.0110345

⊟Function[edit | edit source]

  • reaction:
    EC 2.5.1.10?  ExPASy
    (2E,6E)-farnesyl diphosphate synthase Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone solanesyl diphosphate synthase (TIGR02749; EC 2.5.1.-; HMM-score: 128.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone heptaprenyl diphosphate synthase component II (TIGR02748; EC 2.5.1.30; HMM-score: 116.5)
  • TheSEED  :
    • (2E,6E)-farnesyl diphosphate synthase (EC 2.5.1.10)
    • Dimethylallyltransferase (EC 2.5.1.1)
    • Geranylgeranyl pyrophosphate synthetase (EC 2.5.1.29)
    • Octaprenyl-diphosphate synthase (EC 2.5.1.90)
    Fatty Acids, Lipids, and Isoprenoids Isoprenoids Isoprenoid Biosynthesis  (2E,6E)-farnesyl diphosphate synthase (EC 2.5.1.10)
    and 8 more
    Fatty Acids, Lipids, and Isoprenoids Isoprenoids Isoprenoid Biosynthesis  Dimethylallyltransferase (EC 2.5.1.1)
    Fatty Acids, Lipids, and Isoprenoids Isoprenoids Isoprenoid Biosynthesis: Interconversions  (2E,6E)-farnesyl diphosphate synthase (EC 2.5.1.10)
    Fatty Acids, Lipids, and Isoprenoids Isoprenoids Isoprenoinds for Quinones  (2E,6E)-farnesyl diphosphate synthase (EC 2.5.1.10)
    Fatty Acids, Lipids, and Isoprenoids Isoprenoids Isoprenoinds for Quinones  Dimethylallyltransferase (EC 2.5.1.1)
    Fatty Acids, Lipids, and Isoprenoids Isoprenoids Isoprenoinds for Quinones  Geranylgeranyl pyrophosphate synthetase (EC 2.5.1.29)
    Fatty Acids, Lipids, and Isoprenoids Isoprenoids Polyprenyl Diphosphate Biosynthesis  (2E,6E)-farnesyl diphosphate synthase (EC 2.5.1.10)
    Fatty Acids, Lipids, and Isoprenoids Isoprenoids Polyprenyl Diphosphate Biosynthesis  Geranylgeranyl pyrophosphate synthetase (EC 2.5.1.29)
    Fatty Acids, Lipids, and Isoprenoids Isoprenoids Polyprenyl Diphosphate Biosynthesis  Octaprenyl diphosphate synthase (EC 2.5.1.90)
  • PFAM:
    Terp_synthase (CL0613) polyprenyl_synt; Polyprenyl synthetase (PF00348; HMM-score: 190)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.021533
    • TAT(Tat/SPI): 0.016003
    • LIPO(Sec/SPII): 0.000357
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACF54914 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPFLLLEVLEALQVTIKPAHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFGEAMAILAGDALFLDSYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQXLSLEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTASFEEIGKTPQKDLQAEKSTYPALLGLEESIAFCNQTLDQANEKLEEIAQQIPFETESIVSVVESLRING

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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