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serotype 4
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HU-OH
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Hu15
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Hu17
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INV200
serotype 14
JJA
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MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
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OXC141
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P1031
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R6
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SP49
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SPN032672
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SPN034156
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SPN034183
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SPN994038
serotype 3
SPN994039
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SPNA45
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ST556
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TCH8431/19A
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Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_RS01595 [old locus tag: SPG_0314 ]
  • pan locus tag?: PNEUPAN001120000
  • symbol: cps4A
  • pan gene symbol?: cps2A
  • synonym:
  • product: capsular polysaccharide--peptidoglycan transferase Cps4A

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_RS01595 [old locus tag: SPG_0314 ]
  • symbol: cps4A
  • product: capsular polysaccharide--peptidoglycan transferase Cps4A
  • replicon: chromosome
  • strand: +
  • coordinates: 303775..305220
  • length: 1446
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    ATGAGTAGACGTTTTAAAAAATCACGTTCACAGAAAGTGAAGCGAAGTGTTAATATCGTT
    TTGCTGACTATTTATTTATTGTTAGTTTGTTTTTTATTGTTCTTAATCTTTAAGTACAAT
    ATCCTTGCTTTTAGATATCTTAACCTAGTGGTAACTGCGTTAGTCCTACTAGTTGCCTTG
    GTAGGGCTACTCTTGATTATCTATAAAAAAGCTGAAAAGTTTACTATTTTTCTGTTGGTG
    TTCTCTATCCTTGTCAGCTCTGTGTCGCTCTTTGCAGTACAGCAGTTTGTTGGACTGACC
    AATCGTTTAAATGCGACTTCTAATTACTCAGAATATTCAATCAGTGTCGCTGTTTTAGCA
    GATAGTGATATCGAAAATGTTACGCAACTGACGAGTGTGACAGCACCGACTGGGACTGAT
    AATGAAAATATTCAAAAACTACTAGCTGATATTAAGTCAAGTCAGAATACCGATTTGACG
    GTCAACCAGAGTTCGTCTTACTTGGCAGCTTACAAGAGTTTGATTGCAGGGGAGACTAAG
    GCCATTGTCCTAAATAGTGTCTTTGAAAACATCATCGAGTCAGAGTATCCAGACTACGCA
    TCGAAGATAAAAAAGATTTATACCAAGGGATTCACTAAAAAAGTAGAAGCTCCTAAGACG
    TCTAAGAATCAGTCTTTCAATATCTATGTTAGTGGAATTGACACCTATGGTCCTATTAGT
    TCGGTGTCGCGATCAGATGTCAATATCCTGATGACTGTCAATCGAGATACCAAGAAAATC
    CTCTTGACCACAACGCCACGTGATGCCTATGTACCAATCGCAGATGGTGGAAATAATCAA
    AAAGATAAATTAACCCATGCAGGCATTTATGGAGTTGATTCGTCCATTCACACCTTAGAA
    AATCTCTATGGAGTGGATATCAATTACTATGTGCGATTGAACTTCACTTCTTTCTTGAAA
    ATGATTGACTTATTGGGAGGGGTAGATGTTCATAATGATCAAGAGTTTTCAGCTCTACAT
    GGGAAGTTCCATTTCCCAGTAGGGAATGTCCATCTAGACTCTGAGCAGGCTCTAGGTTTT
    GTACGTGAACGCTACTCACTAGCCGATGGAGACCGTGACCGTGGTCGCAACCAACAAAAG
    GTCATTGTAGCAATTATTCAGAAGTTAACTTCTACAGAGGTTTTGAAAAACTATAGTAGT
    ATTCTTCAAGGATTGCAGGATTCTCTTCAAACAAATATGCCGATTGAGACTATGATAGAT
    TTAGTGAATACTCAGTTGGAAAGTGGGGGGAATTATAAAGTAAATTCTCAAGATTTAAAA
    GGGACAGGTCGGATGGATCTTCCTTCTTATGCAATGCCAGACAGTAACCTCTATGTGATG
    GAAATAGATGATAGTAGTTTAGCTGTAGTTAAAGCAGCTATACAGGATGTGATGGAGGGT
    AGATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1446

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_RS01595 [old locus tag: SPG_0314 ]
  • symbol: Cps4A
  • description: capsular polysaccharide--peptidoglycan transferase Cps4A
  • length: 481
  • theoretical pI: 8.62487
  • theoretical MW: 53534.1
  • GRAVY: 0.0143451

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions Other cell envelope-related function transcriptional attenuator common domain (TIGR00350; HMM-score: 95.7)
  • TheSEED: see SPG_0314
  • PFAM:
    DNA_clamp (CL0060) DNA_PPF; DNA polymerase processivity factor (PF02916; HMM-score: 156.7)
    no clan defined LytR_cpsA_psr; LytR_cpsA_psr family (PF03816; HMM-score: 140.2)
    and 6 more
    GPCR_A (CL0192) 7TMR-DISM_7TM; 7TM diverse intracellular signalling (PF07695; HMM-score: 18.1)
    no clan defined DUF3754; Protein of unknown function (DUF3754) (PF12576; HMM-score: 8.9)
    GPCR_A (CL0192) Per1; Per1-like family (PF04080; HMM-score: 8.3)
    no clan defined TssN; Type VI secretion system, TssN (PF17555; HMM-score: 6.8)
    TgpA_N; TgpA N-terminal domain (PF11992; HMM-score: 5.8)
    GT-C (CL0111) YfhO; Bacterial membrane protein YfhO (PF09586; HMM-score: 5.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 3
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0002
    • Cytoplasmic Membrane Score: 0.9694
    • Cell wall & surface Score: 0.0006
    • Extracellular Score: 0.0297
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001547
    • TAT(Tat/SPI): 0.000339
    • LIPO(Sec/SPII): 0.121933
  • predicted transmembrane helices (TMHMM): 3

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000091078 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAFRYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNRLNATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLTVNQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAPKTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADGGNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAIIQKLTSTEVLKNYSSILQGLQDSLQTNMPIETMIDLVNTQLESGGNYKVNSQDLKGTGRMDLPSYAMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Judy K Morona, David C Miller, Renato Morona, James C Paton
The effect that mutations in the conserved capsular polysaccharide biosynthesis genes cpsA, cpsB, and cpsD have on virulence of Streptococcus pneumoniae.
J Infect Dis: 2004, 189(10);1905-13
[PubMed:15122528] [WorldCat.org] [DOI] (P p)

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