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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_1066 [new locus tag: SPH_RS05165 ]
  • pan locus tag?: PNEUPAN001964000
  • symbol: SPH_1066
  • pan gene symbol?: pavA
  • synonym:
  • product: fibronectin/fibrinogen binding protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_1066 [new locus tag: SPH_RS05165 ]
  • symbol: SPH_1066
  • product: fibronectin/fibrinogen binding protein
  • replicon: chromosome
  • strand: -
  • coordinates: 984254..985999
  • length: 1746
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    ATGTCATTTGACGGATTTTTTTTACACCACATAGTTGAGGAATTGCGAAGCGAATTAGTG
    AATGGTCGCATCCAGAAAATCAATCAGCCTTTTGAACAAGAGTTGGTCTTGCAAATCCGC
    AGCAATCGCCAAAGCCATCGCCTGCTCCTTTCTGCCCATCCAGTTTTTGGACGCATTCAG
    CTGACCCAAACGACTTTTGAAAATCCAGCCCAACCTTCTACCTTTATCATGGTTTTGAGA
    AAGTATTTGCAGGGGGCCCTGATTGAGTCGATTGAGCAAGTGGAAAATGACCGTATTGTG
    GAAATTACAGTTTCCAATAAAAACGAGATTGGAGACCATATCCAGGCTACCTTGATTATC
    GAAATTATGGGGAAACACAGTAATATTCTACTGGTCGATAAAAGCAGTCATAAAATCCTC
    GAAGTTATCAAACACGTCGGCTTTTCACAAAATAGCTACCGCACCTTACTTCCAGGATCG
    ACCTATATCGCTCCGCCAAGTACAGAATCTCTCAATCCTTTTACTATCAAGGATGAAAAG
    CTCTTTGAAATCCTGCAAACCCAAGAACTAACAGCAAAAAATCTTCAAAGCCTCTTTCAA
    GGTCTGGGACGCGATACGGCAAATGAATTGGAAAGGATACTGGTTAGTGAAAAACTTTCC
    GCTTTCCGAAATTTTTTCAATCAGGAAACCAAGCCATGCTTGACTGAGACTTCCTTCAGT
    CCAGTTCCTTTTGCAAATCAGGTGGGAGAGCCTTTTGCAAATCTTTCTGATTTGTTGGAC
    ACCTACTATAAGGATAAGGCTGAGCGCGACCGCGTCAAACAGCAGGCCAGTGAACTGATT
    CGTCGTGTTGAAAATGAACTTCAGAAAAACCGACACAAACTCAAAAAACAGGAAAAAGAG
    TTACTGGCGACAGACAACGCTGAAGAATTTCGTCAAAAAGGAGAATTGCTGACAACCTTC
    CTACACCAAGTGCCTAACGACCAAGACCAGGTTATCCTAGACAACTACTATACCAACCAA
    CCTATCATGATTGCGCTTGATAAGGCTCTGACTCCCAACCAGAATGCCCAACGCTATTTT
    AAACGGTATCAGAAACTCAAAGAAGCTGTCAAATACTTGACTGATTTGATTGAAGAAACC
    AAAGCCACTATTCTCTATCTGGAAAGTGTAGAAACCGTCCTCAACCAAGCTGGACTGGAA
    GAAATCGCTGAAATCCGCGAAGAATTGATTCAAACAGGTTTTATCCGCAGAAGACAACGG
    GAGAAAATCCAGAAACGCAAAAAACTAGAACAATATCTAGCAAGCGATGGCAAAACCATC
    ATCTATGTCGGACGAAACAATCTTCAAAATGAGGAATTGACCTTTAAAATGGCCCGCAAG
    GAGGAACTTTGGTTCCATGCTAAGGACATTCCTGGAAGCCATGTTGTCATCTCAGGAAAT
    CTTGACCCATCTGATGCAGTCAAGACAGACGCAGCAGAGTTAGCTGCCTACTTCTCTCAA
    GGGCGCCTGTCGAATCTGGTGCAGGTAGATATGATTGAAGTCAAAAAACTCAATAAACCA
    ACTGGTGGAAAACCCGGCTTTGTCACTTACACAGGACAAAAGACCCTCCGCGTCACACCA
    GACTCCAAAAAAAATTGCATCCATGAAAAAATCCTGATTTTACTTGAAATCAGGATTTTT
    AACTTACTATTCACTCAAATCATATTCACTTATAGTACTAATCTTTGCCACCTAGCTTCT
    CATTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1746

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_1066 [new locus tag: SPH_RS05165 ]
  • symbol: SPH_1066
  • description: fibronectin/fibrinogen binding protein
  • length: 581
  • theoretical pI: 7.79006
  • theoretical MW: 66913
  • GRAVY: -0.438038

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED  :
    • Fibronectin/fibrinogen-binding protein
  • PFAM:
    H2TH (CL0303) NFACT_N; NFACT N-terminal and middle domains (PF05833; HMM-score: 496.9)
    and 6 more
    NFACT_RNA-bind (CL0684) NFACT-R_1; NFACT protein RNA binding domain (PF05670; HMM-score: 32.7)
    NFACT-R_2; NFACT protein RNA binding domain (PF18297; HMM-score: 30.7)
    no clan defined RbcX; RbcX protein (PF02341; HMM-score: 15.8)
    Siah-Interact_N; Siah interacting protein, N terminal (PF09032; HMM-score: 11.2)
    DUF5798; Family of unknown function (DUF5798) (PF19111; HMM-score: 9.1)
    ALC; Phage ALC protein (PF17527; HMM-score: 6.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.7503
    • Cytoplasmic Membrane Score: 0.0118
    • Cell wall & surface Score: 0.0478
    • Extracellular Score: 0.1901
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002942
    • TAT(Tat/SPI): 0.001268
    • LIPO(Sec/SPII): 0.000387
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSFDGFFLHHIVEELRSELVNGRIQKINQPFEQELVLQIRSNRQSHRLLLSAHPVFGRIQLTQTTFENPAQPSTFIMVLRKYLQGALIESIEQVENDRIVEITVSNKNEIGDHIQATLIIEIMGKHSNILLVDKSSHKILEVIKHVGFSQNSYRTLLPGSTYIAPPSTESLNPFTIKDEKLFEILQTQELTAKNLQSLFQGLGRDTANELERILVSEKLSAFRNFFNQETKPCLTETSFSPVPFANQVGEPFANLSDLLDTYYKDKAERDRVKQQASELIRRVENELQKNRHKLKKQEKELLATDNAEEFRQKGELLTTFLHQVPNDQDQVILDNYYTNQPIMIALDKALTPNQNAQRYFKRYQKLKEAVKYLTDLIEETKATILYLESVETVLNQAGLEEIAEIREELIQTGFIRRRQREKIQKRKKLEQYLASDGKTIIYVGRNNLQNEELTFKMARKEELWFHAKDIPGSHVVISGNLDPSDAVKTDAAELAAYFSQGRLSNLVQVDMIEVKKLNKPTGGKPGFVTYTGQKTLRVTPDSKKNCIHEKILILLEIRIFNLLFTQIIFTYSTNLCHLASH

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

A R Holmes, R McNab, K W Millsap, M Rohde, S Hammerschmidt, J L Mawdsley, H F Jenkinson
The pavA gene of Streptococcus pneumoniae encodes a fibronectin-binding protein that is essential for virulence.
Mol Microbiol: 2001, 41(6);1395-408
[PubMed:11580843] [WorldCat.org] [DOI] (P p)Daniela Pracht, Christine Elm, Joachim Gerber, Simone Bergmann, Manfred Rohde, Marleen Seiler, Kwang S Kim, Howard F Jenkinson, Roland Nau, Sven Hammerschmidt
PavA of Streptococcus pneumoniae modulates adherence, invasion, and meningeal inflammation.
Infect Immun: 2005, 73(5);2680-9
[PubMed:15845469] [WorldCat.org] [DOI] (P p)Nadja Noske, Ulrike Kämmerer, Manfred Rohde, Sven Hammerschmidt
Pneumococcal interaction with human dendritic cells: phagocytosis, survival, and induced adaptive immune response are manipulated by PavA.
J Immunol: 2009, 183(3);1952-63
[PubMed:19570831] [WorldCat.org] [DOI] (I p)A Kadioglu, H Brewin, T Härtel, J L Brittan, M Klein, S Hammerschmidt, H F Jenkinson
Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsis.
Mol Oral Microbiol: 2010, 25(1);50-60
[PubMed:20331793] [WorldCat.org] [DOI] (I p)Sajida Kanwal, Inga Jensch, Gottfried J Palm, Mark Brönstrup, Manfred Rohde, Thomas P Kohler, Daniela Somplatzki, Werner Tegge, Howard F Jenkinson, Sven Hammerschmidt
Mapping the recognition domains of pneumococcal fibronectin-binding proteins PavA and PavB demonstrates a common pattern of molecular interactions with fibronectin type III repeats.
Mol Microbiol: 2017, 105(6);839-859
[PubMed:28657670] [WorldCat.org] [DOI] (I p)Kartik Manne, Sthanam V L Narayana, Debasish Chattopadhyay
Crystal structure of the N-terminal domain of the fibronectin-binding protein PavA from Streptococcus pneumoniae.
Acta Crystallogr F Struct Biol Commun: 2019, 75(Pt 10);657-662
[PubMed:31584015] [WorldCat.org] [DOI] (I p)

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