⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae Hungary19A-6
- locus tag: SPH_RS05165 [old locus tag: SPH_1066 ]
- pan locus tag?: PNEUPAN001964000
- symbol: pavA
- pan gene symbol?: pavA
- synonym:
- product: Rqc2 family fibronectin-binding protein PavA
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS, pseudogene
- locus tag: SPH_RS05165 [old locus tag: SPH_1066 ]
- symbol: pavA
- product: Rqc2 family fibronectin-binding protein PavA
- replicon: chromosome
- strand: -
- coordinates: 984343..985999
- length: 1657
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NC_010380 (984343..985999) NCBI
- BioCyc: SPH_RS05165 BioCyc
- MicrobesOnline: see SPH_1066
- PneumoBrowse for strain D39V: SPV_0854 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1621ATGTCATTTGACGGATTTTTTTTACACCACATAGTTGAGGAATTGCGAAGCGAATTAGTG
AATGGTCGCATCCAGAAAATCAATCAGCCTTTTGAACAAGAGTTGGTCTTGCAAATCCGC
AGCAATCGCCAAAGCCATCGCCTGCTCCTTTCTGCCCATCCAGTTTTTGGACGCATTCAG
CTGACCCAAACGACTTTTGAAAATCCAGCCCAACCTTCTACCTTTATCATGGTTTTGAGA
AAGTATTTGCAGGGGGCCCTGATTGAGTCGATTGAGCAAGTGGAAAATGACCGTATTGTG
GAAATTACAGTTTCCAATAAAAACGAGATTGGAGACCATATCCAGGCTACCTTGATTATC
GAAATTATGGGGAAACACAGTAATATTCTACTGGTCGATAAAAGCAGTCATAAAATCCTC
GAAGTTATCAAACACGTCGGCTTTTCACAAAATAGCTACCGCACCTTACTTCCAGGATCG
ACCTATATCGCTCCGCCAAGTACAGAATCTCTCAATCCTTTTACTATCAAGGATGAAAAG
CTCTTTGAAATCCTGCAAACCCAAGAACTAACAGCAAAAAATCTTCAAAGCCTCTTTCAA
GGTCTGGGACGCGATACGGCAAATGAATTGGAAAGGATACTGGTTAGTGAAAAACTTTCC
GCTTTCCGAAATTTTTTCAATCAGGAAACCAAGCCATGCTTGACTGAGACTTCCTTCAGT
CCAGTTCCTTTTGCAAATCAGGTGGGAGAGCCTTTTGCAAATCTTTCTGATTTGTTGGAC
ACCTACTATAAGGATAAGGCTGAGCGCGACCGCGTCAAACAGCAGGCCAGTGAACTGATT
CGTCGTGTTGAAAATGAACTTCAGAAAAACCGACACAAACTCAAAAAACAGGAAAAAGAG
TTACTGGCGACAGACAACGCTGAAGAATTTCGTCAAAAAGGAGAATTGCTGACAACCTTC
CTACACCAAGTGCCTAACGACCAAGACCAGGTTATCCTAGACAACTACTATACCAACCAA
CCTATCATGATTGCGCTTGATAAGGCTCTGACTCCCAACCAGAATGCCCAACGCTATTTT
AAACGGTATCAGAAACTCAAAGAAGCTGTCAAATACTTGACTGATTTGATTGAAGAAACC
AAAGCCACTATTCTCTATCTGGAAAGTGTAGAAACCGTCCTCAACCAAGCTGGACTGGAA
GAAATCGCTGAAATCCGCGAAGAATTGATTCAAACAGGTTTTATCCGCAGAAGACAACGG
GAGAAAATCCAGAAACGCAAAAAACTAGAACAATATCTAGCAAGCGATGGCAAAACCATC
ATCTATGTCGGACGAAACAATCTTCAAAATGAGGAATTGACCTTTAAAATGGCCCGCAAG
GAGGAACTTTGGTTCCATGCTAAGGACATTCCTGGAAGCCATGTTGTCATCTCAGGAAAT
CTTGACCCATCTGATGCAGTCAAGACAGACGCAGCAGAGTTAGCTGCCTACTTCTCTCAA
GGGCGCCTGTCGAATCTGGTGCAGGTAGATATGATTGAAGTCAAAAAACTCAATAAACCA
ACTGGTGGAAAACCCGGCTTTGTCACTTACACAGGACAAAAGACCCTCCGCGTCACACCA
GACTCCAAAAAAAATTGCATCCATGAAAAAATCCTGA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPH_RS05165 [old locus tag: SPH_1066 ]
- symbol: PavA
- description: Rqc2 family fibronectin-binding protein PavA
- length:
- theoretical pI:
- theoretical MW:
- GRAVY:
⊟Function[edit | edit source]
- TIGRFAM:
- TheSEED: see SPH_1066
- PFAM:
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb:
- DeepLocPro:
- SignalP:
- predicted transmembrane helices (TMHMM):
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: no polycistronic organisation predicted
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0854 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
A R Holmes, R McNab, K W Millsap, M Rohde, S Hammerschmidt, J L Mawdsley, H F Jenkinson
The pavA gene of Streptococcus pneumoniae encodes a fibronectin-binding protein that is essential for virulence.
Mol Microbiol: 2001, 41(6);1395-408
[PubMed:11580843] [WorldCat.org] [DOI] (P p)Daniela Pracht, Christine Elm, Joachim Gerber, Simone Bergmann, Manfred Rohde, Marleen Seiler, Kwang S Kim, Howard F Jenkinson, Roland Nau, Sven Hammerschmidt
PavA of Streptococcus pneumoniae modulates adherence, invasion, and meningeal inflammation.
Infect Immun: 2005, 73(5);2680-9
[PubMed:15845469] [WorldCat.org] [DOI] (P p)Nadja Noske, Ulrike Kämmerer, Manfred Rohde, Sven Hammerschmidt
Pneumococcal interaction with human dendritic cells: phagocytosis, survival, and induced adaptive immune response are manipulated by PavA.
J Immunol: 2009, 183(3);1952-63
[PubMed:19570831] [WorldCat.org] [DOI] (I p)A Kadioglu, H Brewin, T Härtel, J L Brittan, M Klein, S Hammerschmidt, H F Jenkinson
Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsis.
Mol Oral Microbiol: 2010, 25(1);50-60
[PubMed:20331793] [WorldCat.org] [DOI] (I p)Sajida Kanwal, Inga Jensch, Gottfried J Palm, Mark Brönstrup, Manfred Rohde, Thomas P Kohler, Daniela Somplatzki, Werner Tegge, Howard F Jenkinson, Sven Hammerschmidt
Mapping the recognition domains of pneumococcal fibronectin-binding proteins PavA and PavB demonstrates a common pattern of molecular interactions with fibronectin type III repeats.
Mol Microbiol: 2017, 105(6);839-859
[PubMed:28657670] [WorldCat.org] [DOI] (I p)Kartik Manne, Sthanam V L Narayana, Debasish Chattopadhyay
Crystal structure of the N-terminal domain of the fibronectin-binding protein PavA from Streptococcus pneumoniae.
Acta Crystallogr F Struct Biol Commun: 2019, 75(Pt 10);657-662
[PubMed:31584015] [WorldCat.org] [DOI] (I p)